DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and VAV1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_005419.2 Gene:VAV1 / 7409 HGNCID:12657 Length:845 Species:Homo sapiens


Alignment Length:937 Identity:185/937 - (19%)
Similarity:316/937 - (33%) Gaps:317/937 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1414 EIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLL 1478
            |.|:|....|.|..:..............::.|  ::|:.:|....:.|:..||..|...|.::.
Human   155 EDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPP--KMTEYDKRCCCLREIQQTEEKYTDTLGSIQ 217

  Fly  1479 EHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAI 1543
            :|:|:|::|  ||...:|..:|.||.:::.....||:.::|:|......|.::            
Human   218 QHFLKPLQR--FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQ------------ 268

  Fly  1544 GSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQ-------QHSS----TL 1597
              .|:.|...|.:|..:|:....|.|        | |....|||...|       |.::    ||
Human   269 --VFIKYKERFLVYGRYCSQVESASK--------H-LDRVAAAREDVQMKLEECSQRANNGRFTL 322

  Fly  1598 ESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDH 1662
            ...|:.|:||:|||.||||::...|. .|.|..:|..||..|..:|:.:||::|.:|....|   
Human   323 RDLLMVPMQRVLKYHLLLQELVKHTQ-EAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQI--- 383

  Fly  1663 LFRQHQKSCKQPIDLSPGDLLYYGGVE---WLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKER 1724
              ...|.|.:. :|.|   |.:||..:   .|.|:    .:::..::....|:...|:: :||.|
Human   384 --TNFQLSIEN-LDQS---LAHYGRPKIDGELKIT----SVERRSKMDRYAFLLDKALL-ICKRR 437

  Fly  1725 LRQKKKLMGVSSKNATNEVEIIRYQV--LIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSE 1787
                    |.|            |.:  .:.:...|||..|:.|.|:             ::.|.
Human   438 --------GDS------------YDLKDFVNLHSFQVRDDSSGDRDN-------------KKWSH 469

  Fly  1788 KVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTL 1852
            ...::.:..|.....|.|| |::.::.:....:.:.|....:.:.:||..| |.|.         
Human   470 MFLLIEDQGAQGYELFFKT-RELKKKWMEQFEMAISNIYPENATANGHDFQ-MFSF--------- 523

  Fly  1853 ERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQ 1917
                ::.|.......|.:.....|.:.|..      ..|..:|.....|..|        .|||.
Human   524 ----EETTSCKACQMLLRGTFYQGYRCHRC------RASAHKECLGRVPPCG--------RHGQD 570

  Fly  1918 MQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQ-----QQLMQQGHAHAHPHPHPHPREPP 1977
                 |.|           |....:.|::.|.:::.:     .::.|:.:.           .||
Human   571 -----FPG-----------TMKKDKLHRRAQDKKRNELGLPKMEVFQEYYG-----------LPP 608

  Fly  1978 PPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQ 2042
            ||....|.|..:..||..:   ||:|.|::..:|                 ..|||..:|     
Human   609 PPGAIGPFLRLNPGDIVEL---TKAEAEQNWWEG-----------------RNTSTNEIG----- 648

  Fly  2043 ARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQ 2107
                        :.|.                                                 
Human   649 ------------WFPC------------------------------------------------- 652

  Fly  2108 TQSRTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARES 2172
              :|.:..:|                .|.||:.|...:....||..|...:|         .|..
Human   653 --NRVKPYVH----------------GPPQDLSVHLWYAGPMERAGAESILA---------NRSD 690

  Fly  2173 GHKQRRDRDRNPTETDATARF--MDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDTG 2235
            |....|.|.::..|...:.::  ..||:..:..|.|...|          .:|||  :.|.|...
Human   691 GTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRIT----------EKKAF--RGLTELVE 743

  Fly  2236 DHQQN---------DSSL-----SPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTT--GPSE 2284
            .:|||         |::|     .||.:||               ||||     .|:|.  |.::
Human   744 FYQQNSLKDCFKSLDTTLQFPFKEPEKRTI---------------SRPA-----VGSTKYFGTAK 788

  Fly  2285 RSGDETEEEATTSSL--ASHIVVIDKK 2309
            ...|....:.:..||  ...|.:::||
Human   789 ARYDFCARDRSELSLKEGDIIKILNKK 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 55/201 (27%)
PH2_Tiam1_2 1650..1823 CDD:269957 32/177 (18%)
PH 1693..1812 CDD:278594 21/120 (18%)
VAV1NP_005419.2 CH_VAV1 2..121 CDD:409111
RhoGEF 195..371 CDD:238091 55/201 (27%)
PH_Vav 385..508 CDD:269930 30/165 (18%)
C1_VAV1 510..566 CDD:410417 13/83 (16%)
SH3_VAV1_1 596..658 CDD:212912 20/160 (13%)
SH2_Vav1 665..767 CDD:198268 26/122 (21%)
SH3_VAV1_2 786..839 CDD:212909 6/30 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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