DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and Psd2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_036017188.1	Gene:	Psd2 / 74002	MGIID:	1921252	Length:	771	Species:	Mus musculus

Alignment Length:	815	Identity:	167/815 - (20%)
Similarity:	282/815 - (34%)	Gaps:	282/815 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 GRASSQ--SSRFSGS------RSSHEIGRG----YPPRNLY----LELERERSCIEGSPPSDNVM 511
            |.|:|:  ||..||.      ..:.|..||    .|..||.    |.|.::.:.:|     |::.
Mouse    34 GTAASEGLSSHISGPGGEKTLEGTMEPVRGPDVALPGLNLSLTNGLALGQDGNILE-----DSIE 93

  Fly   512 FDNQCYATTPSSSNGNSDQDQSYGQQQSSGQHPQQQQGPPQRSSRHQHHHQQAPNVTPTPGSP-- 574
            |        .:..:|.::::...|.       |....|.||..             ...||.|
Mouse    94 F--------KTWRSGPAEEEDVPGS-------PCPDAGDPQLG-------------LDCPGEPDV 130

  Fly   575 ------TSRLLLEYEMHLRNTLAKGMDA--------ESYSLHTFEA----LLSQSMENLEFAESL 621
                  |...:||.|: ||.|....:|:        ||.|..:|||    |:.|...:...|.:.
Mouse   131 RDGFSATFEKILESEL-LRGTQYSSLDSLDVLSLTDESDSCVSFEAPLTPLIQQRARDSPEAGAG 194

  Fly   622 PGSNQRSP---------------YPLRRPNAKSSTLPLPPHRPLSTI-------------RDKER 658
            .|:....|               .||||..:.|.:..:..|..|:::             .|.|.
Mouse   195 LGNGDMGPEGDLGATGGCDGELGSPLRRSISSSRSENVLSHLSLTSVPNGFHEDGPGGSGGDDED 259

  Fly   659 DRDRDGYYSDRNELIRERERERDRGYLSDHNSSFSNSR----------CASC--IGESAR--AQW 709
            |.|.|       :|:........:..|||.:|..|:|.          ...|  :.|:||  |:.
Mouse   260 DEDTD-------KLLNSASDTSLKDGLSDSDSELSSSEGLEPGSTDPLANGCQGVSEAARRLARR 317

  Fly   710 FRHSDGWR--SGSSTIGSGSGHGMMTQQIPGSGHKRSPWD---------------SLPSLRQ--- 754
            ..|.:|::  ..:..:|..:....:.     :|...|.:|               :.|.:.:
Mouse   318 LYHLEGFQRCDVARQLGKNNEFSRLV-----AGEYLSFFDFSGLTLDRALRTFLKAFPLMGETQE 377

  Fly   755 -----------------DSSLNDSGYKS----------------------------ARADSLEQR 774
                             |.|.::.|..:                            |..|.|...
Mouse   378 RERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHVNIGKKMSCQQFIANLDQLNDG 442

  Fly   775 AEFIRQDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSD-EDDGES 838
            .:|.: |.|::.|.|.:..:.    :.:|:..:.|.   :.||:.||...:.|..|:. .|.|..
Mouse   443 QDFAK-DLLKTLYNSIKNEKL----EWAIDEDELRK---SLSELVDDKFGTGTKKVTRILDGGNP 499

  Fly   839 VMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKH-QIELAR----KRGWKGYWVCLKG 898
            .:..|....||            ..|.|.|:      ||.| .::..|    :||||.::..|||
Mouse   500 FLDVPQALNAT------------TYKHGVLT------RKTHADMDGKRTPRGRRGWKKFYAVLKG 546

  Fly   899 TTLLFYPCDSREGRSV-EAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVEL 962
            |.|.....:.|..::: |...|:.|.|..|:.....::.|:..:..|.||....:|||||.:.|:
Mouse   547 TILYLQKDEYRLDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEM 611

  Fly   963 ENWVNSIHSACA--------AA------FARHRGKTGTLHLLQEEIFR----------------- 996
            .:|:..|:...|        ||      |.|....:.|..|.|||..|
Mouse   612 LSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQLRSHENKLRQVTAELAEHR 676

  Fly   997 ---LEKAIESDHKLKHMAELQQSVVTDQETR-----HQIQTQILQWEENLERLHCEQFRLRCYMA 1053
               ||:.::|....::  .|::..:|.:::|     |.:..:|....::|||:...       :|
Mouse   677 CHPLERGLKSKEAEEY--RLKEHYLTFEKSRYETYIHLLAVKIKVGSDDLERIEAR-------LA 732

  Fly  1054 SLQSGELP-------NPKSLLTH----VSRPTKNT 1077
            ::: |:.|       :|...|.|    .|:.||:|
Mouse   733 TIE-GDDPALRKTHSSPALSLGHGPVTGSKATKDT 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	39/144 (27%)
		PH	873..974	CDD:278594	31/106 (29%)
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
Psd2	XP_036017188.1	Sec7	294..462	CDD:238100	23/173 (13%)
Psd2	XP_036017188.1	PH_EFA6	508..631	CDD:270107	37/140 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910