DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and tiam1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_002938487.1 Gene:tiam1 / 734013 XenbaseID:XB-GENE-1006478 Length:1590 Species:Xenopus tropicalis


Alignment Length:1631 Identity:507/1631 - (31%)
Similarity:764/1631 - (46%) Gaps:343/1631 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   459 NNTMGRA-SSQSSRFS--GSRSSHEIGRGYP-PRNLYLELERERSCIEGSPPS--DNVM------ 511
            :.|:||. :|:|.|.|  .||.:.....|.| .||  .|:....|.....|.|  :|.|      
 Frog    18 HGTLGRKHTSRSLRISNKNSRRTRHASSGKPVHRN--SEVSNRSSSTPSIPQSLAENGMEPYSQD 80

  Fly   512 -----FDNQCY--------------ATTPS------------SSNGNSDQDQSYGQQQSSGQHPQ 545
                 ||::.:              :.|||            .|..:.::.:.||:     .|..
 Frog    81 ANLDDFDSRDWVDMGLRPVSYHTDSSVTPSLNSSTVLTAASMQSMQDCEESRLYGE-----DHSY 140

  Fly   546 QQQGPPQRSSRHQHHHQQAPNVTPTPGSPTSRL---------LLEYEM------HLRNT-----L 590
            .|.|    :.|.|.:....||:.........|.         .||:.:      ||.:|     .
 Frog   141 FQDG----NGRSQIYTTNGPNLLDAASFKKKRSKSADIWREDSLEFSLSDLSQEHLTSTEEILCS 201

  Fly   591 AKGMDAESYSLHTFEALLSQSMENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTIRD 655
            .:..|.|       |.:::::..|.:...|...::....||...|:|..:..|            
 Frog   202 TEEKDCE-------ETIIAEAGNNAKLNSSQRANSLTDLYPQINPHASVNGAP------------ 247

  Fly   656 KERDRDRDGYYSDRNELIRERERERDRGYLSDHNSS-----FSN-----SRCASCIGESARAQWF 710
                |.:...|. ||.:....|.|   .|..|..|:     :||     .|.:.|:.|.|.....
 Frog   248 ----RSKFMVYC-RNLVSHSPESE---NYKMDPTSAEETPPYSNYSTLPCRKSHCLSEGAANLKL 304

  Fly   711 RHSDGWRSGSSTIGSGSGHG---MMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLE 772
            .|::            |.||   ..||.:...|             :.|...|||.::|..|:  
 Frog   305 SHTN------------SMHGRRAKTTQDVNTGG-------------EGSEFTDSGIEAATTDT-- 342

  Fly   773 QRAEFI-RQDSLRSEYLSDRESRYGIVQQASIESTDSRM---CY------LTSSEISDDDRMSLT 827
               :.| |:.::.:...|...||..|...:...||...:   .|      |..|..|.::....:
 Frog   343 ---DIISRRSNITTSSYSPTASRVFIGSDSGSSSTGDVLRQGVYENFRRELEMSRASRENLEEAS 404

  Fly   828 TAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKH-QIELARKRGWKG 891
            :|:||| .....::||.::....|||.     |.|||||.|:||.:|:.||: ::|.|.:|.||.
 Frog   405 SALSDE-QSSGTLSSPGQSDILLTAAQ-----GTVRKAGALAVKNFLVHKKNKKVEPATRRKWKQ 463

  Fly   892 YWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQA 956
            |||.|||.||.||..|.|.|....:.|||.:.|:.:|:|.:|||||:|::||||.:.|||:|||.
 Frog   464 YWVSLKGCTLFFYETDGRSGIDNNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQT 528

  Fly   957 PCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQ 1021
            ..|.|||||:.:||||||...||...|..|:.||:.||.:||:.|:.|.|:|.|.|:|.|.|||.
 Frog   529 TSQTELENWITAIHSACATTVARQHHKEDTVKLLKSEIKKLEQKIDMDEKMKKMGEMQISSVTDA 593

  Fly  1022 ETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTV 1086
            :.:..|..||..||:|||:...:.||.|||::|||.|||||||.||...|||||..:.:||:|:|
 Frog   594 KKKKTILDQIFVWEQNLEQFQMDLFRYRCYLSSLQGGELPNPKRLLAFASRPTKVAMGRLGIFSV 658

  Fly  1087 SSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRS-------MQMNSR--------- 1135
            |||||.:.||:         |....:||...:||  |.|.|||       :..:|:         
 Frog   659 SSFHALVAART---------GESGVRRRTQAMSR--SASKRRSRFSSLWGLDTSSKKKQGRTSVT 712

  Fly  1136 ----------------------DEPEKTFKVAM----PDNAYSTVYLRDAMS------------- 1161
                                  .|.:|..:||:    |.|..:.:::.|.::             
 Frog   713 QVFSDGSESVKKSLEGIFDETMSEEKKEKEVALSTVHPHNPDTDIWVHDYLTPSWVCLPNDQPVL 777

  Fly  1162 --------VEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCM 1218
                    .::.|...|....|:...:::|:|...|.:...| :|...:.|...|:..  :|:|.
 Frog   778 IVIHPDDMAKDALEIICKTHQLDYTSYYLRLKFLMDNQTQIY-IPKPEEEIYELLYKE--IEICP 839

  Fly  1219 KILYQVELQR-TTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVING 1282
            |:...::|:: ....:.:||:     :.:.|.......||:.|::..:|...|:..|||:|.||.
 Frog   840 KVTKHIQLEKGGGASESFGFA-----LSSVEEDGRHHLYVNNVKESGLAYKKGLKVGDEVMEINA 899

  Fly  1283 AIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPD-----LVGIMRVTD-DMIDSLVCPPPPTDPP 1341
            ....:|:...|:::|. :.||.:.:|:.    ||     |..:.|.:| |..|.|:         
 Frog   900 KPARELNSSVLKNILC-KSSLYLTVRTC----PDAGDCPLEALPRRSDTDCNDFLL--------- 950

  Fly  1342 VMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKP 1406
                                   |.:.:...:.:.|...|..:..||                  
 Frog   951 -----------------------LSNRDCSETDSCSETAPEEIEVQL------------------ 974

  Fly  1407 TSRTSSFEIENLLKTAEQ--ETRKS-----SPTGSVT-SSVSTTALTPSRQLTDAEKLRKVVMEL 1463
               .:..|.:::.|:.||  ..|:|     ||...:: |..:..||...||||||:|||||:.||
 Frog   975 ---DAPEEADSINKSTEQVAALRRSPHEMNSPDSCLSPSEFAGPALATMRQLTDADKLRKVICEL 1036

  Fly  1464 VDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFN 1528
            ::|||||||.||.|:|.||:|:::|.||:..|::.||||:.|:|.||.:||:.||:.:.|.||..
 Frog  1037 LETERTYVKDLNCLMERYLKPLQKEPFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLE 1101

  Fly  1529 KFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQH 1593
            |.|...||:.|||::|.:||||.:.|||||:|||||:|..|||...:.:...:.||.|:||||||
 Frog  1102 KLEKVEQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDSNFKAFLDAQNPKQQH 1166

  Fly  1594 SSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGA 1658
            ||||||||||||||||||||||:::.:|||..::||.||..|:|.|.|||.||||||:|||||||
 Frog  1167 SSTLESYLIKPIQRILKYPLLLKELYSLTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEYGA 1231

  Fly  1659 IFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKE 1723
            :||.|..:.....|:..|||.||||.:..|.|||....|||.||..||  ..||||:|||.:.|:
 Frog  1232 VFDQLISEQSGEVKEVADLSMGDLLLHNTVTWLNPPASLGKWKKDPEL--ATFVFKTAVVLVYKD 1294

  Fly  1724 RLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEK 1788
            ..:|||||.|....:...:.:..|::.:||...:|||..:..|.:::.:.|::|::|:.:.|.|:
 Frog  1295 SSKQKKKLGGSHRASMFEDRDPFRFRHMIPTEALQVRTMTTSDAETNSVCEIVHVKSESEGRPER 1359

  Fly  1789 VYVLSNSTADFRNAFLKTIRQIIRESVRNM-----SIPMKN----FGGSS-GSVSGHSSQGMGSM 1843
            .:.|..|....:..||:.:..|:|:..|..     |:|...    |||.. .::.|.......::
 Frog  1360 AFHLCCSNPGRKKEFLRAVHSILRDKHRRQLLKTESLPNSQQYVPFGGKRLCALKGARPTMNRAV 1424

  Fly  1844 GYPGNSQTLER--PKQQITIVHGSHTLGKPKKKSGSQ------RHSAGNIDYD-------NLSGS 1893
            ..|..|....|  .:.:.||...|.....|:|.|..:      :.|:.:.|.|       :|:..
 Frog  1425 SAPSRSLARRRRLVRNRFTIDSDSIFSNDPEKDSDQETEPSPPQQSSNSGDTDRWVEEQFDLAQY 1489

  Fly  1894 QEADDL 1899
            :|.||:
 Frog  1490 EEQDDV 1495

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 67/125 (54%)
PH 873..974 CDD:278594 53/101 (52%)
TIAM1_RBD 1141..1219 CDD:176413 17/102 (17%)
PDZ_signaling 1221..1308 CDD:238492 20/87 (23%)
RhoGEF 1456..1647 CDD:238091 110/190 (58%)
PH2_Tiam1_2 1650..1823 CDD:269957 65/177 (37%)
PH 1693..1812 CDD:278594 38/118 (32%)
tiam1XP_002938487.1 PH1_Tiam1_2 431..557 CDD:269937 67/125 (54%)
Tiam_CC_Ex 571..668 CDD:375811 50/96 (52%)
RBD 765..834 CDD:366972 10/69 (14%)
PDZ_signaling 842..924 CDD:238492 20/87 (23%)
RhoGEF 1032..1221 CDD:214619 108/188 (57%)
PH2_Tiam1_2 1223..1394 CDD:269957 63/172 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 224 1.000 Domainoid score I2502
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 626 1.000 Inparanoid score I845
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002962
OrthoInspector 1 1.000 - - oto103528
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2782
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
66.050

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