DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and c1orf131

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_002931536.1	Gene:	c1orf131 / 733757	XenbaseID:	XB-GENE-940972	Length:	273	Species:	Xenopus tropicalis

Alignment Length:	161	Identity:	38/161 - (23%)
Similarity:	61/161 - (37%)	Gaps:	26/161 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   741 HKRSPWDSLPSLRQDSSLNDSGYKSARAD------------SLEQRAEFIRQDSLRSEYLSDRES 793
            ||:....|:|.::|..:...|. ||.:.|            |..:|...:..|||:.|..:..:|
Frog    29 HKKKKTQSVPEIQQSPAAPISN-KSEKEDFELNVAIPNTCSSHRKRNVTLFFDSLKEEMCNRTKS 92

  Fly   794 RYGIVQQASIESTDSRMCYLTSSE-ISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFN 857
                 .:||....:|..|...|.| ::...|....:.:..|...|:|:....| :..|....|||
Frog    93 -----TEASSTVANSNQCSENSIEVVTFRSRKKAKSQIEPESCSETVLIDKEK-EENGQKGQSFN 151

  Fly   858 CTGA---VRKAGFLSVKKWLLRKKHQIELAR 885
            ...|   :.|.|....:|   .|:...|..|
Frog   152 FEKARLEIHKFGITGYRK---EKQRTFEQER 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	7/29 (24%)
		PH	873..974	CDD:278594	3/13 (23%)
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
c1orf131	XP_002931536.1	DUF4602	114..232	CDD:373798	16/70 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900