DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and Arhgef6

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_690014.2 Gene:Arhgef6 / 73341 MGIID:1920591 Length:795 Species:Mus musculus


Alignment Length:646 Identity:136/646 - (21%)
Similarity:235/646 - (36%) Gaps:151/646 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  1266 AMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEE--QSLSMMMRSSRT------EPPD------ 1316
            ::.||::.   ..:||..:...::...||...:.:  .:::..::...|      ||.|      
Mouse    58 SLKNGVVL---CKLINRLLPGSVEKYCLEPQTEADCIDNINDFLKGCATLQVEVFEPDDLYSGAN 119

  Fly  1317 -------LVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSP 1374
                   |:.:.:.|:|.:....|....:.....|.:....:.||:.          :||..|..
Mouse   120 FSKVLNTLLAVNKATEDQLSERPCGRSSSLSAATSSQTNPQVAVPST----------APEQHSEE 174

  Fly  1375 ATSFVDPAAMAAQLAVGG---------------------VGGVVVGGLGVAKPTSRTSSFEIENL 1418
            .....:..  :.||.|..                     |..|..||........||..|. .|.
Mouse   175 KAEMTENG--SHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFP-SNY 236

  Fly  1419 LKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLE 1483
            ::..:...|..||  .......|..||.:....       |:..::|||:.|.|.|.:||..||.
Mouse   237 VREIKPSERPLSP--KAIKGFDTAPLTKNYYTV-------VLQNILDTEKEYAKELQSLLVTYLR 292

  Fly  1484 PMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFL 1548
            |::....||..|...|.||..|:.|||:...|.|||             |.:|......:|...|
Mouse   293 PLQSNNNLSTVEFTCLLGNFEEVCTFQQTLCQALEE-------------CSKFPENQHKVGGCLL 344

  Fly  1549 YYVNHFK-LYSSFCASHSKAQKVL--HPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILK 1610
            ..:.||| :|.::||:|..|..||  |.::    |:.|:..:.........|.:.|.||..|:.|
Mouse   345 NLMPHFKSMYLAYCANHPSAVNVLTQHSDD----LERFMENQGASSPGILILTTSLSKPFMRLEK 405

  Fly  1611 YPLLLQQM-RNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQP 1674
            |..|||:: |::.||..| |..:.:|:...:.:.....::::..:           ...:...:|
Mouse   406 YVTLLQELERHMEDTHPD-HQDILKAIIAFKTLMGQCQDLRKRKQ-----------LELQILSEP 458

  Fly  1675 IDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMC--------FVFKSAVVFLCKERLRQKKKL 1731
            |....||     .::.|....|:.::   :..|..|        .:|.|.::.|           
Mouse   459 IQAWEGD-----DIKTLGNVIFMSQV---VMQHGACEEKEERYFLLFSSVLIML----------- 504

  Fly  1732 MGVSSKNATNEVEIIRYQVLIPVTEVQV-RASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNS 1795
                  :|:..:....||..||:..:.| |....:..|..|  |:      .....|::.|..|:
Mouse   505 ------SASPRMSGFMYQGKIPIAGMVVNRLDEIEGSDCMF--EI------TGSTVERIVVHCNN 555

  Fly  1796 TADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPK 1856
            ..||:. :::.:.::.:......|:...    ||.|.|.|||  ..|.|.|..  .||.|:
Mouse   556 NQDFQE-WMEQLNRLTKGPTSCGSLSKT----SSSSCSTHSS--FSSTGQPRG--PLEPPQ 607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492 6/43 (14%)
RhoGEF 1456..1647 CDD:238091 59/194 (30%)
PH2_Tiam1_2 1650..1823 CDD:269957 27/181 (15%)
PH 1693..1812 CDD:278594 21/127 (17%)
Arhgef6NP_690014.2 CH 29..129 CDD:214479 11/73 (15%)
RhoGEF67_u1 139..183 CDD:293221 7/55 (13%)
SH3_alphaPIX 185..241 CDD:212993 11/56 (20%)
RhoGEF 265..442 CDD:238091 59/201 (29%)
PH_Cool_Pix 473..571 CDD:269932 21/126 (17%)
PH 490..571 CDD:278594 18/106 (17%)
RhoGEF67_u2 597..697 CDD:293220 5/13 (38%)
betaPIX_CC 700..786 CDD:293131
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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