DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and TRIO

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_009049.2 Gene:TRIO / 7204 HGNCID:12303 Length:3097 Species:Homo sapiens


Alignment Length:2151 Identity:409/2151 - (19%)
Similarity:667/2151 - (31%) Gaps:829/2151 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   561 HQQAPNVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLH----------------TFEALLS 609
            |:.:.|:   ||..|.  :...|..::|.|.:....|:..||                .||....
Human  1089 HRNSVNM---PGMVTH--IKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAK 1148

  Fly   610 QSME----NLEF---AESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTIRDKERDRDR----- 662
            |::|    |.||   ..:..||:.:....|           |..|........:.::|.:     
Human  1149 QALEWIHDNGEFYLSTHTSTGSSIQHTQEL-----------LKEHEEFQITAKQTKERVKLLIQL 1202

  Fly   663 -DGYYSDRNELIRERERERDRGYLSDHNSSFSNSRCASCIGE-----SARAQWFRHSDGWRSGSS 721
             ||:.              ::|    |..:....:|.:.:.:     |.|.:.:|.|.....|.|
Human  1203 ADGFC--------------EKG----HAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGIS 1249

  Fly   722 TIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSE 786
            :..:.|...:....||.|    .|...:........||:...||||      |.|||..:.:::|
Human  1250 SDSNKSSKSLQLDIIPAS----IPGSEVKLRDAAHELNEEKRKSAR------RKEFIMAELIQTE 1304

  Fly   787 --YLSD----------------RESRYGIVQQASI-------------------------ESTDS 808
              |:.|                .|...|||.:..|                         ...|.
Human  1305 KAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDV 1369

  Fly   809 RMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFL-SVKK 872
            ..|::|   .:|..:|.:|...:..|..:.::..         |.|.|:  ...::.|.. |:..
Human  1370 GHCFVT---WADKFQMYVTYCKNKPDSTQLILEH---------AGSYFD--EIQQRHGLANSISS 1420

  Fly   873 WLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVE------AAPK------HLIIVD 925
            :|::...:|        ..|.:.||.   |...|:..:|...:      :.||      ||.:::
Human  1421 YLIKPVQRI--------TKYQLLLKE---LLTCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLE 1474

  Fly   926 G----------AIMQPIPE--HPK------RD---YIFCLSTAFG---------DAYLFQA---- 956
            |          .|:|...:  .||      |:   ::|.:|..|.         ..||:::    
Human  1475 GFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFT 1539

  Fly   957 ------------PCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHK-LK 1008
                        ||:..|  ||               |:|.|   ...:|.....:||:... :|
Human  1540 SELGVTEHVEGDPCKFAL--WV---------------GRTPT---SDNKIVLKASSIENKQDWIK 1584

  Fly  1009 HMAELQQSVVTDQETRHQIQTQILQWEENL-ERLHCEQFRLRCYMASLQSGE----------LPN 1062
            |:.|:             ||.:.:..:..| |.:|..:..........:.||          .|:
Human  1585 HIREV-------------IQERTIHLKGALKEPIHIPKTAPATRQKGRRDGEDLDSQGDGSSQPD 1636

  Fly  1063 PKSLLTHVSRPTKNTL--NKL--GVFTVSSFHAFICARSPSLLNNLLAGRG-------------- 1109
            ..|:   .||.::|||  :||  |.......|.|....|    |.|...||              
Human  1637 TISI---ASRTSQNTLDSDKLSGGCELTVVIHDFTACNS----NELTIRRGQTVEVLERPHDKPD 1694

  Fly  1110 -----ATKRRPPMLSRSNSGS-----SRRSMQM----NSRDEPEKTFKVAMPDNAYSTV--YLRD 1158
                 .|.|.|........||     ||.||:|    |.:|....:...|.|..:.:::  ::..
Human  1695 WCLVRTTDRSPAAEGLVPCGSLCIAHSRSSMEMEGIFNHKDSLSVSSNDASPPASVASLQPHMIG 1759

  Fly  1159 AMSVEEFLASACARRNLNPMEHFVRVKKRR----DMEDHNYFVPHRNDLIENYLHNHEFVEVCMK 1219
            |.|      |...:|..|.:..::....||    ..:.|          ::...|.|:......|
Human  1760 AQS------SPGPKRPGNTLRKWLTSPVRRLSSGKADGH----------VKKLAHKHKKSREVRK 1808

  Fly  1220 ILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAI 1284
            .. ....|:.:.:.  ..:.:.|.:|...|.:.|..........|.....|..:|:|     ||.
Human  1809 SA-DAGSQKDSDDS--AATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEE-----GAD 1865

  Fly  1285 VSDLD---MMYLESVLQ-----EEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPP 1341
            ...|.   .:...|:||     ::.|..:::|.:.:|.|....::...::::.|          .
Human  1866 AVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKS----------K 1920

  Fly  1342 VMSEEMITGLIV-----PAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGL 1401
            :..|:..:.|:|     .:|.:|.:...|.|   .|||    :|                     
Human  1921 MALEDRPSSLLVDQGDSSSPSFNPSDNSLLS---SSSP----ID--------------------- 1957

  Fly  1402 GVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDT 1466
                                 |.|.||||                     ..::...|:.|||:|
Human  1958 ---------------------EMEERKSS---------------------SLKRRHYVLQELVET 1980

  Fly  1467 ERTYVKHLNNLLEHYLEPMKRETFLSN--AEINALFGNIHEIVTFQRQ-FLQNLEESLDLEPDFN 1528
            ||.||:.|..::|.|:..||.:....:  .:...:|||||:|..:.|. ||..||:.|: :|:  
Human  1981 ERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLE-DPE-- 2042

  Fly  1529 KFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAA--RNPKQ 1591
                         .:||.|:.:.....:|.::|.:..|::         |.:.|::..  .:.||
Human  2043 -------------KLGSLFVKHERRLHMYIAYCQNKPKSE---------HIVSEYIDTFFEDLKQ 2085

  Fly  1592 Q--HSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHE 1654
            :  |...|...||||:|||:||.|||:.....:...:.:...|..|::.|..|....|:|..:..
Human  2086 RLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGR 2150

  Fly  1655 EYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMC-----FVFK 1714
            ..|  ||                  |.::..|.   |.:.|......:...|...|     |:|:
Human  2151 LQG--FD------------------GKIVAQGK---LLLQDTFLVTDQDAGLLPRCRERRIFLFE 2192

  Fly  1715 SAVVFLCKERLRQKK--KLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIH 1777
            ..|:|  .|.|.:||  .:.|...||:      |:...|  ..|..|.....|            
Human  2193 QIVIF--SEPLDKKKGFSMPGFLFKNS------IKVSCL--CLEENVENDPCK------------ 2235

  Fly  1778 LRSQLQRRSEKV---YVLSNSTADFRNAFLKTIRQIIRESVRN----MSIPMK----NFGGSSGS 1831
              ..|..|:..|   ::|.:|:...|..::..|.||: |:.||    ::.|::    :.||..|.
Human  2236 --FALTSRTGDVVETFILHSSSPSVRQTWIHEINQIL-ENQRNFLNALTSPIEYQRNHSGGGGGG 2297

  Fly  1832 VSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEA 1896
            .||.|..|.||.|.                       |.|   ||...||.|             
Human  2298 GSGGSGGGGGSGGG-----------------------GAP---SGGSGHSGG------------- 2323

  Fly  1897 DDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQG 1961
               |.|.|..             |:..|.|...:                               
Human  2324 ---PSSCGGA-------------PSTSRSRPSRI------------------------------- 2341

  Fly  1962 HAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATL---GRTP 2023
                            |.|:|     ||...:  :.....|:.|.|...||..|..:|   |..|
Human  2342 ----------------PQPVR-----HHPPVL--VSSAASSQAEADKMSGTSTPGPSLPPPGAAP 2383

  Fly  2024 NHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVAASF 2088
                          ..|..|   .|..||.:......:: .:|.|....|||..:       .:.
Human  2384 --------------EAGPSA---PSRRPPGADAEGSERE-AEPIPKMKVLESPRK-------GAA 2423

  Fly  2089 NLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPR---QSPRQSPKQDIEVIEIFESEAE 2150
            |.| |||....|.|||            .||...|...||   .||..||               
Human  2424 NAS-GSSPDAPAKDAR------------ASLGTLPLGKPRAGAASPLNSP--------------- 2460

  Fly  2151 RLAASQQVAVVHQHPSDQARESGHKQRRDRDRNPTETDATARFMDKHLSDLEQENLTDGTCDIVA 2215
                                                                          :.:
Human  2461 --------------------------------------------------------------LSS 2463

  Fly  2216 YMESLREKAFDPQDLAEDTGDHQQNDSSLSPEPQTIVENTQQTVVVDIESPSRPAT-----ESDS 2275
            .:.||.::.|.|....:..|...   ||:...|                 .|||.:     :|||
Human  2464 AVPSLGKEPFPPSSPLQKGGSFW---SSIPASP-----------------ASRPGSFTFPGDSDS 2508

  Fly  2276 TGNTTGPSERSGDETEEEATTSSLASHIVVIDKKVDKIFKAKSPERPASTKVKGGRRQIYISPDR 2340
            ....|......|.:|:..:|.||.:...|                  .||:..|.          
Human  2509 LQRQTPRHAAPGKDTDRMSTCSSASEQSV------------------QSTQSNGS---------- 2545

  Fly  2341 CKSQGSSPVRIIKIKSPRTSLSD------QGKRLSVCSSRDNSQDRLSAGRRTPSPRRSSEG--- 2396
             :|..||.:..:.:....|::.:      ||:.:.:.:|  |.|:.....|.......::||   
Human  2546 -ESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQILAS--NQQNMFLVFRAATDQCPAAEGWIP 2607

  Fly  2397 GGILKHTT-----GPDPGILKPPSS-------PAKSKSPDRSCLKKG-----------GPSHVCS 2438
            |.:|.||:     .|| |.||..:|       ..||:..|:...::|           |.|:..|
Human  2608 GFVLGHTSAVIVENPD-GTLKKSTSWHTALRLRKKSEKKDKDGKREGKLENGYRKSREGLSNKVS 2671

  Fly  2439 VETLSP 2444
            |:.|:|
Human  2672 VKLLNP 2677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 31/183 (17%)
PH 873..974 CDD:278594 28/158 (18%)
TIAM1_RBD 1141..1219 CDD:176413 12/83 (14%)
PDZ_signaling 1221..1308 CDD:238492 16/94 (17%)
RhoGEF 1456..1647 CDD:238091 55/197 (28%)
PH2_Tiam1_2 1650..1823 CDD:269957 38/186 (20%)
PH 1693..1812 CDD:278594 28/128 (22%)
TRIONP_009049.2 SEC14 69..204 CDD:214706
SPEC 230..445 CDD:238103
Spectrin 1 311..418
SPEC 341..566 CDD:238103
Spectrin 2 538..644
SPEC 567..783 CDD:238103
SPEC 787..1014 CDD:238103
Spectrin 3 878..984
SPEC 908..1137 CDD:238103 11/52 (21%)
Spectrin 4 1109..1216 22/135 (16%)
SPEC 1143..1243 CDD:197544 22/128 (17%)
RhoGEF 1295..1465 CDD:238091 32/194 (16%)
PH1_Kalirin_Trio_like 1472..1594 CDD:270060 27/154 (18%)
PH 1505..1590 CDD:278594 20/117 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1601..1650 11/51 (22%)
SH3_Kalirin_1 1659..1718 CDD:212786 12/62 (19%)
SH3-RhoG_link 1715..1972 CDD:293215 58/360 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1779..1906 25/144 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1927..1965 14/86 (16%)
RhoGEF 1970..2143 CDD:238091 55/197 (28%)
PH2_Kalirin_Trio_p63RhoGEF 2148..2286 CDD:270061 38/185 (21%)
PH 2175..2271 CDD:278594 27/120 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2287..2552 91/537 (17%)
SH3_Kalirin_2 2555..2613 CDD:212787 11/59 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2639..2660 4/20 (20%)
I-set 2685..2776 CDD:254352
Ig 2699..2776 CDD:299845
STKc_Trio_C 2788..3050 CDD:271015
S_TKc 2796..3050 CDD:214567
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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