DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and Dnmbp

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_082305.1 Gene:Dnmbp / 71972 MGIID:1917352 Length:1580 Species:Mus musculus


Alignment Length:1885 Identity:349/1885 - (18%)
Similarity:604/1885 - (32%) Gaps:661/1885 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   715 GWRSGSSTIGS-GSGHGMMTQQIPGSGHKRSPWDSLPSLRQ--DSSLNDSGYKSARADSLEQRAE 776
            ||..|.|..|: |.......|::..|...|. |.:..:|.|  :.||..:......:..|::..:
Mouse   103 GWLQGRSCWGAWGFFPSSCVQELCLSSRSRR-WHAQSALLQAPEYSLGQARALMGLSAQLDEELD 166

  Fly   777 FIRQDSLR-------SEYLSDRESRYGIVQQASIE------STDSRMCYLTSSEISDDDRMSLTT 828
            |...|.:.       ..:..:.|.|.||..:..:|      :.|..:    :|...||..::...
Mouse   167 FREGDLITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESV----NSRSGDDSAVNGEV 227

  Fly   829 AV--------SDEDDGES--VMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIEL 883
            .|        .||||.:|  ...:.|:.:|..|....|.....::..|.|               
Mouse   228 DVPPEEAESGGDEDDQQSGTYGIALYRFQALETNELDFEVGDRIQILGTL--------------- 277

  Fly   884 ARKRGW-KGYWVCLKGTTLLFYP------CDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYI 941
              :.|| :|   ||||.|.:| |      |.|.......|.|:.            ...||    
Mouse   278 --EDGWLEG---CLKGKTGVF-PHRFVKLCPSNRTEETTAQPQE------------SSFPK---- 320

  Fly   942 FCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHK 1006
                               :.|:.|               ||:|                     
Mouse   321 -------------------DSESSV---------------GKSG--------------------- 330

  Fly  1007 LKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVS 1071
                    .|||  :|.|.:      .||       ||:.|        ...:||...|:     
Mouse   331 --------DSVV--EEARQE------PWE-------CEEER--------PDYDLPGQASV----- 359

  Fly  1072 RPTKNTLNKLGVFTVSSFHAFICARSPSL-LNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSR 1135
             |..:...:....|:|.........||.: |...||...:|   |......|..||:..:.::.:
Mouse   360 -PQDHVAPEWTGDTISGQDKDASGSSPDVDLERPLAKDLST---PDPSEEVNGVSSQPQVPIHPK 420

  Fly  1136 DEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHR 1200
                                   ....:.:|.:..:.:..:|....|.::.|  ..|::...|.|
Mouse   421 -----------------------VQKSQHYLTAGGSHQTSDPFSELVPLEAR--TRDYSSLPPRR 460

  Fly  1201 NDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENA--------ERQDELC--- 1254
                                         |..|.|.|...|..::.|        :|....|   
Mouse   461 -----------------------------TYAQGWSFQKPASHLQRASSLTASRLDRPSHFCHPA 496

  Fly  1255 --CYVSRVE---DKSVAMHN---------GI------------IKGDEIMVINGAIVSDLDMMYL 1293
              .|..:.:   :.:.::|:         |:            .:||.:         |||....
Mouse   497 MASYAQKHQTSTENTASLHDPPERPERRPGLQDRGPATDITTASQGDSL---------DLDSKLT 552

  Fly  1294 ESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTD-----DMI----DSL-----------VCPPPP- 1337
            :.:::.|:|||    ...|||..:|....:.|     |::    :||           :.|||| 
Mouse   553 QQLIEFEKSLS----GPSTEPETIVRRFSIMDFYSEKDIVRGSSNSLPSQAFPERRKTLRPPPPR 613

  Fly  1338 --TDPPVMSEEMI--------TGLIVPA-------------------------PGWNGTSKDLYS 1367
              |..|:.|..::        |.::.|:                         |||....|: .|
Mouse   614 PRTPTPISSHLLVDQSPKPVPTLVVRPSRPAPLPPPAQQRMNTASPKPTSCAHPGWEAPEKE-DS 677

  Fly  1368 PEAESSPATSFVDPAAMA--------------AQLAVGGV---------GGVVVGGLGVAKPTSR 1409
            ...|.|||.:|..|:.:|              ||..:..:         ....:..|...:.|.:
Mouse   678 EHMEKSPAQTFPCPSMLARIRDVEQDLDTCTRAQEELNLLLEEKQDDPSRAETLETLRSYESTIQ 742

  Fly  1410 TSSFEIENL---LKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYV 1471
            :.:.|::.|   ...:.|.:..::|.|||::.      .|.:::  .||..|||.||:.|||.|:
Mouse   743 SLTLELQQLRDMTLLSSQSSSLAAPFGSVSTE------NPEQRM--LEKRAKVVAELLQTERDYI 799

  Fly  1472 KHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQF 1536
            :.|...:|..:.|: ::..:.|.:...||||:..::...:|.|..||.|     |......|.  
Mouse   800 RDLEMCIERVMVPL-QQAQVPNVDFEGLFGNMQTVIKVSKQLLAALEIS-----DAVGMSSCD-- 856

  Fly  1537 RNVLFAIGSAFLYYVNHFK-LYSSFCASHSKAQKVLHPNEGNHA----LQEFLAARNPKQQHSST 1596
               ....|..||.:.:..: .|..:|.:|.:|..:|...|.:..    ||::||.......:.: 
Mouse   857 ---CLVPGPVFLDHRDELEGTYRVYCQNHDEAISLLEMYEKDEKTQKHLQDYLADLKGCTNYIN- 917

  Fly  1597 LESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFD 1661
            |.|:||||:|||::|||||.::.|.|.....:.|.|..|:..::::..:|||.:|..:       
Mouse   918 LGSFLIKPVQRIMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRKD------- 975

  Fly  1662 HLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLEL-----HAMCFV--FKSAVVF 1719
             |..:::|..:..:         ...:..|||...   |||...:     |...|.  .|..|..
Mouse   976 -LVLKYRKGDEDSL---------MEKISKLNIHSI---IKKSSRVSSHLKHLTGFAPQLKDEVFE 1027

  Fly  1720 LCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDM----DSHFL--WELIH- 1777
            ..::..|.:::|:....::.:..::.||....:.|    |.|.|..|:    ..|.|  :|.:| 
Mouse  1028 ETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKV----VAAMSIWDLCMERGHHDLEQFEKVHR 1088

  Fly  1778 -----LRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSS 1837
                 |.::.:.|:|::.:             ..:.|::........:..|.|.           
Mouse  1089 YISDQLFTRFKERTERLVI-------------NPLNQLLNMFTGPYKLVQKRFD----------- 1129

  Fly  1838 QGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPP- 1901
               ..:.:...::..|:.|.               ||:..:..||.| :|:.|: ||..|:||. 
Mouse  1130 ---KLLDFYNCTERAEKLKD---------------KKTLEELQSARN-NYEALN-SQLLDELPKF 1174

  Fly  1902 -------SVGVVH-YASGHTHG-----QQMQP-AGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQ 1952
                   ....:| ||..|...     :|:|| ......:...|::..|..   |.|.:..||.|
Mouse  1175 QQYAQSLFTNCIHGYAEAHCDFVQQALEQLQPLLSLLKATDREGNLIAIFL---EEHSRVLQQLQ 1236

  Fly  1953 QQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKA 2017
            .         ....|...|.||:|                .||     |:...:.|:      |.
Mouse  1237 V---------FTFFPESLPAPRKP----------------FER-----KTTDRQSSR------KT 1265

  Fly  2018 TLGRTPNHLTLSTTSTLSVGSTGSQARLIQSS----HPPASYQPVLMKDLGKPSPDESELESESE 2078
            .|| .|:::.              |:..::||    :||                       |..
Mouse  1266 LLG-MPSYML--------------QSEELRSSLLARYPP-----------------------EKL 1292

  Fly  2079 VHAAQVAASFNLSLGSSGSLFASD------ARDNQ-TQSR-------TQSQIHSLHPSPRQSPRQ 2129
            .|   |..:||.:.....||...|      .:|.. :|:|       |:..::|....|     .
Mouse  1293 FH---VQRNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLVDNGVTKGFVYSSFLKP-----Y 1349

  Fly  2130 SPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESG-----HKQRRDRDRNPTETDA 2189
            :||                     .|...|.|..|.|.::..||     |:|...........:.
Mouse  1350 NPR---------------------CSHSDASVASHSSTESEHSGSSPGCHRQNSHSALTFNSNNM 1393

  Fly  2190 TARFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDTGDHQQNDSSLSPEPQTIVEN 2254
            |..|    .|.|......|.:        .|::.|.:...::.:||..:...|:.|.:|....:.
Mouse  1394 TVSF----TSGLALTQPQDAS--------PLKDCAHETLAVSWNTGHPETGPSTCSSDPGFSCQR 1446

  Fly  2255 TQQTVVVDIESPSRPATESDSTGNTTGPSERSGDETEEEATTSSLASHIVVIDKKVDKIFKAKSP 2319
            .       :.:|:..|.:.....:|....:|....:|             |:.      :.....
Mouse  1447 R-------LGNPADGARDISQPASTLRGCQRGSPHSE-------------VVG------YSVPGQ 1485

  Fly  2320 ERPASTKVKGGRRQIYISPDRCKSQGSS---------PVRIIKIKSPRTSLSDQGKRLSVCSSRD 2375
            ....|..:||..|......||.:..|||         .:...|.::|........:||.:...:|
Mouse  1486 NDQGSDSIKGSARVCQAPEDRDRGVGSSETEGNQVYFAIYTFKARNPNELSVLANQRLRIHEFKD 1550

  Fly  2376  2375
            Mouse  1551  1550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 22/131 (17%)
PH 873..974 CDD:278594 18/107 (17%)
TIAM1_RBD 1141..1219 CDD:176413 7/77 (9%)
PDZ_signaling 1221..1308 CDD:238492 20/123 (16%)
RhoGEF 1456..1647 CDD:238091 56/195 (29%)
PH2_Tiam1_2 1650..1823 CDD:269957 30/191 (16%)
PH 1693..1812 CDD:278594 25/137 (18%)
DnmbpNP_082305.1 SH3_DNMBP_N1 7..56 CDD:212728
SH3_DNMBP_N2 70..124 CDD:212729 6/20 (30%)
SH3_DNMBP_N3 150..200 CDD:212730 7/49 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..245 8/37 (22%)
SH3 248..297 CDD:302595 16/69 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 304..446 38/275 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 500..546 5/54 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 589..688 20/99 (20%)
RhoGEF 787..969 CDD:279015 56/193 (29%)
BAR_DNMBP 1020..1211 CDD:153273 42/238 (18%)
SH3_DNMBP_C1 1292..1348 CDD:212732 12/58 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1356..1384 8/27 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1426..1514 19/113 (17%)
SH3_DNMBP_C2 1520..1576 CDD:213017 5/31 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3224
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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