DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and Plekha2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_003751669.2	Gene:	Plekha2 / 684785	RGDID:	1586710	Length:	425	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	83/404 - (20%)
Similarity:	128/404 - (31%)	Gaps:	139/404 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   863 RKAGFLSVK------KWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHL 921
            |..|||.::      |:|.|               |::.......|.:..|:         |::|
  Rat     9 RICGFLDIEDNENSGKFLRR---------------YFILDTQANCLLWYMDN---------PQNL 49

  Fly   922 IIVDGAI------------MQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACA 974
            .:..||:            :....:.||..:.|.:: |....|..||..|.:|::||.:::.|..
  Rat    50 AVGAGAVGSLQLTYISKVSIATPKQKPKTPFCFVIN-ALSQRYFLQANDQKDLKDWVEALNQASK 113

  Fly   975 AAFARHRGKTGTLHLLQEEIFRL--EKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQ---- 1033
            ....    |.||:.:..|.:..|  ...:|...::.:..|:...||        :||.|.|
  Rat   114 ITVP----KAGTVPVATEVLKNLTAPPTLEKKPQVAYKTEIIGGVV--------VQTPISQNGGD 166

  Fly  1034 ------------------------------------------------WEENLERLHCEQFRLRC 1050
                                                            |:.....|  :.|.: |
  Rat   167 GPEGSEPGTHAFLRRSQSYVPTSGCRPPSGPSLIKSGYCVKQGNVRKSWKRRFFAL--DDFTI-C 228

  Fly  1051 YMASLQSGE----LPNPKSLLTHVSRPTKNTL----NKLGVFTVS-SFHAFICARSPSLLNNLLA 1106
            |....|..|    :|....|.||........|    |...:.|.| :|  ::.|.||..:.:.:.
  Rat   229 YFKCEQDREPLRTIPLKDVLKTHECLVKSGDLLMRDNLFEIITTSRTF--YVQADSPEDMRSWIE 291

  Fly  1107 GRGATKR------RPPMLSRSNS----GSSRRSMQMN---SRDEP---EKTFKVAMPDNAYSTVY 1155
            |.||..:      |.|..|||.|    |||..:...|   ||..|   ||......|..|.|...
  Rat   292 GIGAAVQALKCHPREPSFSRSISLPRPGSSGLTSGPNSILSRRRPPAEEKRALCKAPSMASSWQP 356

  Fly  1156 LRDAMSVEEFLASA 1169
            .......:|.|.||
  Rat   357 WTPVPQAKEKLLSA 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	27/139 (19%)
		PH	873..974	CDD:278594	21/112 (19%)
		TIAM1_RBD	1141..1219	CDD:176413	7/29 (24%)
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
Plekha2	XP_003751669.2	PH1_TAPP1_2	1..119	CDD:270089	26/138 (19%)
Plekha2	XP_003751669.2	PH2_TAPP1_2	192..306	CDD:270090	22/118 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910