DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and SPTBN1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_003119.2 Gene:SPTBN1 / 6711 HGNCID:11275 Length:2364 Species:Homo sapiens


Alignment Length:2557 Identity:456/2557 - (17%)
Similarity:836/2557 - (32%) Gaps:823/2557 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   375 INNNTRRKTKSTEDMNVDT---STLKRMLKPMPSTESPVTSPEMGRRRYN-YYNANAAQTLGHPP 435
            :|::..|.:....|:..|.   ..|.::|:.:.....|  .|..||.|.: ..|.:.|.......
Human    64 VNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLP--KPTKGRMRIHCLENVDKALQFLKEQ 126

  Fly   436 HMHQHGMAMGMGGGGGGGHHIMNNN---TMGRASSQSSRFSGSRSSHEI---------------- 481
            .:|...|         |.|.|::.|   |:|...:...||.....|.|.                
Human   127 RVHLENM---------GSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLW 182

  Fly   482 ----GRGYPPRNLYLELERERSCIEGSPPSDNVMFDNQCYATTP--------SSSNGNSDQDQSY 534
                ..|||..|::......|         |.:.|:...:...|        ..||.:.:...::
Human   183 CQMKTAGYPNVNIHNFTTSWR---------DGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAF 238

  Fly   535 GQQQSSGQH--------PQ--QQQGPPQRS-----SRHQHHHQQAPNVTPTPGSPTSRLLLEYEM 584
            ...:   ||        |:  ....|.::|     ..:.|:.           |....|.:|.: 
Human   239 NLAE---QHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYF-----------SKMKALAVEGK- 288

  Fly   585 HLRNTLAKGMDAESYSLHTFEALLSQSME----------NLEFAESLPGSNQRSPYPLRRPNAKS 639
            .:...|...::.|. .:..:|:|.|..:|          |.:||.||.|..|:    |:..|. .
Human   289 RIGKVLDNAIETEK-MIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQ----LQAFNT-Y 347

  Fly   640 STLPLPPHRP--------LSTIRDKERDRDRDGYYSDRNELIRERERERDRGYLSDHNSSFSNSR 696
            .|:..||...        |.||:.|.|..::..|.....:||            ||.|.:     
Human   348 RTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLI------------SDINKA----- 395

  Fly   697 CASCIGESARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDS 761
                               |                 :::..:.|:|.     .:||.:      
Human   396 -------------------W-----------------ERLEKAEHERE-----LALRNE------ 413

  Fly   762 GYKSARADSLEQRA-EFIRQDSLRSEYLSDRESRYGIVQQ-------ASIESTDSRMCYLTSSEI 818
               ..|.:.|||.| .|.|:.::|..:||:.:.   :|.|       .::|:...:...:.:...
Human   414 ---LIRQEKLEQLARRFDRKAAMRETWLSENQR---LVSQDNFGFDLPAVEAATKKHEAIETDIA 472

  Fly   819 SDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLL------RK 877
            :.::|:....||:.|.:.|:     |......||          ||...:.:.::||      |:
Human   473 AYEERVQAVVAVARELEAEN-----YHDIKRITA----------RKDNVIRLWEYLLELLRARRQ 522

  Fly   878 KHQIELARKR---------GW----------KGYWVCLKGTTLLFYP---------CDSREGRSV 914
            :.::.|..::         .|          :.|...|.|...|...         ..:...|.|
Human   523 RLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGV 587

  Fly   915 EAAPKHLIIVDGAIMQPIPEHPKRDYI----FCLSTAFGDAYLFQAPCQV--------------- 960
            .|:.:. ...||...:|......||.:    ||          :|..||:               
Human   588 NASAQK-FATDGEGYKPCDPQVIRDRVAHMEFC----------YQELCQLAAERRARLEESRRLW 641

  Fly   961 -------ELENWVNSIHSACAAAFARHRGK--TGTLHLL-QEEIFRLEKAIESDHKLKHMAELQQ 1015
                   |.|.|:.......:   :...||  |..:.|| :...|..|.:..|.|..:.:.|.:.
Human   642 KFFWEMAEEEGWIREKEKILS---SDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGED 703

  Fly  1016 SVVTDQETRHQIQTQIL----QWEENLERLHC------------EQFR-----LRCYMASL---- 1055
            .:..:.....:|:.:|:    || .|||:|..            .||:     :..:|..:    
Human   704 MIAEEHFGSEKIRERIIYIREQW-ANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIV 767

  Fly  1056 QSGELPNP-----------KSLLTHVS--RPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAG 1107
            .|.::.:.           |.:...::  |||.:||:: ....:...|    |.||.:...|   
Human   768 SSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHE-QASALPQEH----AESPDVRGRL--- 824

  Fly  1108 RGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASAC-- 1170
                           ||...|..::   .|..:..|.|:.|    |:.|....|.    |.||  
Human   825 ---------------SGIEERYKEV---AELTRLRKQALQD----TLALYKMFSE----ADACEL 863

  Fly  1171 ----ARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHE-----FVEVCMKILY---- 1222
                ..:.||.|:   ..:|..|:|    .:.||.:.:|..::|..     ..::..::::    
Human   864 WIDEKEQWLNNMQ---IPEKLEDLE----VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHP 921

  Fly  1223 ---QVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDE----IMVI 1280
               :::.|:..|...|  |...||::  .::|.|.        .::::.|..::.:|    |...
Human   922 SEKEIKAQQDKLNTRW--SQFRELVD--RKKDALL--------SALSIQNYHLECNETKSWIREK 974

  Fly  1281 NGAIVSDLDM-MYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDM---IDSLVCPPPPTDPP 1341
            ...|.|..|: ..|..|:..::.|:.|.|       |||.|.....|:   .:.|     .::.|
Human   975 TKVIESTQDLGNDLAGVMALQRKLTGMER-------DLVAIEAKLSDLQKEAEKL-----ESEHP 1027

  Fly  1342 VMSEEMITGLIVPAPGWNGTSKDLYSPEA---ESSPATSFV------------DPAAMAAQLAVG 1391
            ..::.:::.|...:..|......|.:.||   |:|....|:            ...|:|::    
Human  1028 DQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE---- 1088

  Fly  1392 GVGGVVVGGLGVAKPTSRTSSFE-------IENLLKTAEQETRKSSPTGSVTSSVSTTA----LT 1445
                        ..|.:.|.:.:       |:|.:...|::.:|....|.:.:...|.|    |.
Human  1089 ------------DMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141

  Fly  1446 PSRQLTDA-----EKLRKVVMELVDTERTYVK----------HLNN---LLEHYLEP-------- 1484
            ...|..|.     .|:.:....|:.....|.:          .|||   :|.|...|        
Human  1142 QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEA 1206

  Fly  1485 --MKRETFLSNAE-----INALF---------GNIH------EIVTFQRQFLQNLEESLDL---- 1523
              .|:|.|::..:     |||:.         |||:      ::.:...:..:|.|.:.:|    
Human  1207 AIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRL 1271

  Fly  1524 --EPDFNKF-EHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLA 1585
              ..|..|| :.|.:..           .::|. |:.::...|:.:|:. ||.....|  |.|:|
Human  1272 KDNRDLQKFLQDCQELS-----------LWINE-KMLTAQDMSYDEARN-LHSKWLKH--QAFMA 1321

  Fly  1586 ARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQ 1650
            .....::....:|.                :.|:.:::....|.| :.|.|.|:.|:.|.:....
Human  1322 ELASNKEWLDKIEK----------------EGMQLISEKPETEAV-VKEKLTGLHKMWEVLESTT 1369

  Fly  1651 RIHEEYGAIFD----HLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGK--------IKKG 1703
            :...:  .:||    .||.|   ||   .||..    :..|:|....||..||        :||.
Human  1370 QTKAQ--RLFDANKAELFTQ---SC---ADLDK----WLHGLESQIQSDDYGKDLTSVNILLKKQ 1422

  Fly  1704 LELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIR-------YQVLIPVTEVQVRA 1761
            ..|.....|.|..:     |.|:.:.:.:....| :|:||:..|       .::|.|:.|.:...
Human  1423 QMLENQMEVRKKEI-----EELQSQAQALSQEGK-STDEVDSKRLTVQTKFMELLEPLNERKHNL 1481

  Fly  1762 SSAK-------DMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMS 1819
            .::|       |::...||.           .|:: .|:.||....|  |:|::.:|:   :|.:
Human  1482 LASKEIHQFNRDVEDEILWV-----------GERM-PLATSTDHGHN--LQTVQLLIK---KNQT 1529

  Fly  1820 IPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGN 1884
            :..:        :.||.         |......||.:..:|                        
Human  1530 LQKE--------IQGHQ---------PRIDDIFERSQNIVT------------------------ 1553

  Fly  1885 IDYDNLSGS---QEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQ 1946
             |..:||..   |...||....|::...:...| ::::.|....:........|...|..|.:..
Human  1554 -DSSSLSAEAIRQRLADLKQLWGLLIEETEKRH-RRLEEAHRAQQYYFDAAEAEAWMSEQELYMM 1616

  Fly  1947 QQQQQQQQQ---------QLMQQG--------H----------AHAHPHPHPHPREPPPPPIRQP 1984
            .:::.:.:|         |:::|.        |          |.:||       |.....:|| 
Human  1617 SEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP-------ESERISMRQ- 1673

  Fly  1985 HLHHHSSDIERIDPGTKSEGEED------------------------SQQGTIRPKATLGRTPNH 2025
                  |.::::..|.|...||.                        :::..:.....||:...|
Human  1674 ------SKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEH 1732

  Fly  2026 LTLSTTS----TLSVGSTGSQA---------RLIQSSHPPASYQPVLMKDLGKPSPDESEL-ESE 2076
            :|:....    ....|:.|.:.         .||.|.|..|:........|.:...|..|| ::.
Human  1733 VTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797

  Fly  2077 SEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPRQSPRQSPKQDIEV 2141
            :::    :|||:.|      ..|..||::      ...:|...|   ::.|.:..|.  :..:|.
Human  1798 TQI----LAASYEL------HKFYHDAKE------IFGRIQDKH---KKLPEELGRD--QNTVET 1841

  Fly  2142 IE----IFESEAERLAASQQVAVVHQHPSD----QARESGHKQRRDRDRNPTETDATARFMDKHL 2198
            ::    .||.:.:.|...     |.|...|    ||..:|.|....:.|.....:|....:|  .
Human  1842 LQRMHTTFEHDIQALGTQ-----VRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLD--A 1899

  Fly  2199 SDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDTGDHQQNDSSLSPEPQTIVE---NTQQTVV 2260
            .:..:..|.| |.|...:...:|:.....:|:.      :|.::...|...:.||   |..|.:.
Human  1900 CESRRVRLVD-TGDKFRFFSMVRDLMLWMEDVI------RQIEAQEKPRDVSSVELLMNNHQGIK 1957

  Fly  2261 VDIESPSRPATESDSTGNTTGPSERSGDETEEEATTSSLASHIVVIDKKVDK------IFKAKSP 2319
            .:|::.:...|.....|.:....:....|..:|...........:|||..|:      |.:....
Human  1958 AEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQF 2022

  Fly  2320 ERPASTK---VKGGRRQIYISPDRCKSQGSSPVRIIKI--------KSPRT-----SLSDQGKRL 2368
            .|.||..   :.|  ::.|:|   .:..|.|...:.|:        ||..|     |..::...|
Human  2023 SRDASVAEAWLLG--QEPYLS---SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTL 2082

  Fly  2369 SVCSSRDNSQDRLSAGRRTPSPRRS---------------SEGGGILKHTTGPDPGILKPPSSPA 2418
            .:...| ..|:.....||.|||..|               |:|..:.::      |:.....||.
Human  2083 ELLEVR-RQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQN------GLPAEQGSPR 2140

  Fly  2419 KSKSPDRSCLKKGGPSHVCSVETLSPRVSP---RGSMDHLSPDRGMTSSSCLRHSPRSSFDSHGE 2480
            .:::.|.|.:..|......|.:..||..||   |.:...|......|..:..:.:|.:..:....
Human  2141 MAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLN 2205

  Fly  2481 SDHNLDVPHGSRKRSMSAHGSF 2502
            ..|..:. |..:..|.|.|..:
Human  2206 RKHEWEA-HNKKASSRSWHNVY 2226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 29/186 (16%)
PH 873..974 CDD:278594 25/160 (16%)
TIAM1_RBD 1141..1219 CDD:176413 19/88 (22%)
PDZ_signaling 1221..1308 CDD:238492 18/98 (18%)
RhoGEF 1456..1647 CDD:238091 43/240 (18%)
PH2_Tiam1_2 1650..1823 CDD:269957 43/198 (22%)
PH 1693..1812 CDD:278594 30/140 (21%)
SPTBN1NP_003119.2 Actin-binding 2..275 40/233 (17%)
CH_SPTBN1_rpt1 3..156 CDD:409165 21/102 (21%)
SAC6 48..>530 CDD:227401 105/591 (18%)
CH_SPTB_like_rpt2 173..277 CDD:409097 16/115 (14%)
Spectrin 1. /evidence=ECO:0000255 303..411 30/170 (18%)
Spectrin 2. /evidence=ECO:0000255 423..525 22/119 (18%)
SPEC 530..743 CDD:238103 39/227 (17%)
Spectrin 3. /evidence=ECO:0000255 530..636 18/116 (16%)
Spectrin 4. /evidence=ECO:0000255 639..742 21/106 (20%)
SPEC 642..849 CDD:238103 43/240 (18%)
Spectrin 5. /evidence=ECO:0000255 745..847 21/127 (17%)
Spectrin 6. /evidence=ECO:0000255 850..952 22/116 (19%)
SPEC 851..1061 CDD:238103 46/244 (19%)
Spectrin 7. /evidence=ECO:0000255 957..1060 23/114 (20%)
SPEC 958..1169 CDD:238103 42/238 (18%)
Spectrin 8. /evidence=ECO:0000255 1063..1166 17/118 (14%)
Spectrin 9. /evidence=ECO:0000255 1170..1258 16/87 (18%)
SPEC 1171..1380 CDD:238103 44/242 (18%)
Spectrin 10. /evidence=ECO:0000255 1276..1376 23/133 (17%)
SPEC 1381..1592 CDD:238103 55/286 (19%)
Spectrin 11. /evidence=ECO:0000255 1381..1482 28/116 (24%)
Spectrin 12. /evidence=ECO:0000255 1486..1590 26/163 (16%)
Interaction with ANK2. /evidence=ECO:0000269|PubMed:15262991 1563..2093 102/585 (17%)
SPEC 1593..1805 CDD:238103 35/229 (15%)
SPEC 1806..2027 CDD:238103 45/251 (18%)
Spectrin 2017..>2075 CDD:395348 12/62 (19%)
Spectrin 17. /evidence=ECO:0000255 2018..2097 16/84 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2089..2196 23/112 (21%)
Mediates interaction with CAMSAP1. /evidence=ECO:0000269|PubMed:24117850 2149..2177 7/27 (26%)
PH_beta_spectrin 2200..2305 CDD:269975 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2309..2364
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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