DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and SOS2

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_008870.2 Gene:SOS2 / 6655 HGNCID:11188 Length:1332 Species:Homo sapiens


Alignment Length:1385 Identity:246/1385 - (17%)
Similarity:427/1385 - (30%) Gaps:469/1385 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1447 SRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSN------AEINALFGNIHE 1505
            |.:|...:.:|..:.|    ||.|::.||.:::.:     ||.|||:      ::|..:|.||.:
Human   194 SGELNYYDLVRTEIAE----ERQYLRELNMIIKVF-----REAFLSDRKLFKPSDIEKIFSNISD 249

  Fly  1506 IVTFQRQFLQNLEESLDLEPDFNKFEHCGQ-FRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQK 1569
            |.....:.|..:|:::::..:.:.....|. |.::  |...||..|             .:.:|.
Human   250 IHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDL--AEEQAFDPY-------------ETLSQD 299

  Fly  1570 VLHPNEGNH----------ALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDT 1624
            :|.|....|          ||.....|...|:.....|...::.|:.....|..||:|::..::.
Human   300 ILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEE 364

  Fly  1625 RADEHVHLCEALKGMEKVAEHINEMQRIHEEYG----------AIFDHLFRQHQKSCKQPIDLSP 1679
            :.|... |.:|:..:..:.   ..|.||:::|.          ..:.|..|....:.|:..::..
Human   365 QEDREC-LNQAITALMNLQ---GSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQK 425

  Fly  1680 GDLLYYGGVEWLNISDFLGK---------IKKG--------LELHAMCFVFKSAVVFLCKERLRQ 1727
                        ||..:.||         |.:|        .|.|...|   ..::..||....|
Human   426 ------------NIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLF---DGLMISCKPNHGQ 475

  Fly  1728 KKKLMGVSSKNATNEVEIIRYQVLIPVTE------------------VQVRASSAKDMDSHFLWE 1774
             .:|.|.||.....:.:.:..::.|...|                  :...|.||::.::   |.
Human   476 -TRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNN---WM 536

  Fly  1775 L----IHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNM----------SIPMKNF 1825
            .    :|.||.|.|..:.|.:...:....|....:..|.::::|..|:          .||:.. 
Human   537 AALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK- 600

  Fly  1826 GGSSGSVSGHSSQGMGSMGYPGNSQTLE-------RPKQQITIVHGSHTLGKPKKKSGSQRHSAG 1883
            ||:...:....:..|  ...|...:|..       :|::.::::.....:.:|:.          
Human   601 GGTVVKLIERLTYHM--YADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEP---------- 653

  Fly  1884 NIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFR----------------GRSKTVGD 1932
             .|.|.|  :.|..:.|.|..:..:..     :.:||...|                .|...:.:
Human   654 -TDADKL--AIEKGEQPISADLKRFRK-----EYVQPVQLRILNVFRHWVEHHFYDFERDLELLE 710

  Fly  1933 VTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERID 1997
            ..|...||......::..:...:.:.::..|.|:...|....|.|||||     ..|.|      
Human   711 RLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPI-----EWHIS------ 764

  Fly  1998 PGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKD 2062
                                    .|.........||.......|..|::|.    .|:.|...:
Human   765 ------------------------KPGQFETFDLMTLHPIEIARQLTLLESD----LYRKVQPSE 801

  Fly  2063 LGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSP 2127
            |......:.:.|..|......:..:.||:|.....:.  :|.:.:.:....|:|           
Human   802 LVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV--EAENFEERVAVLSRI----------- 853

  Fly  2128 RQSPRQSPKQDIEVIEIFE------SEAERLAASQQVAVVHQHPSDQARESGHKQRRDRDRNPTE 2186
                       ||::::|:      ...|.::|...|:|.....:.:|     .|.|.|......
Human   854 -----------IEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEA-----LQERKRKILDEA 902

  Fly  2187 TDATARFMDKHLSDLEQEN----------LT------DGTCDIVAYMESLREKAFD------PQD 2229
            .:.:.....|:|..|:..|          ||      :|..|.      |::|..|      .:.
Human   903 VELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDF------LKKKGKDLINFSKRRK 961

  Fly  2230 LAEDTGDHQQNDSS-----LSPEPQTIVENTQ--------------------------------- 2256
            :||.||:.||..:.     :.|:.:...||..                                 
Human   962 VAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFP 1026

  Fly  2257 QTVVVDIESPS-RPATESDSTGNTTG-------PSERSG--------DETEEEATTSSLASHIVV 2305
            :.....::||. ||.|  ...|:|:|       |.||..        .|||.|:|.|:       
Human  1027 RKSTFSLKSPGIRPNT--GRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSA------- 1082

  Fly  2306 IDKKVDKIFKAKSPERPASTKVKGGR-RQIYISPDRCKSQGS----SPVRIIKIKSPRTSLSDQG 2365
                      ..||..|::..|.... ..:::..|...|.||    :||.:...||         
Human  1083 ----------PTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKS--------- 1128

  Fly  2366 KRLSVCSSRDNSQDRLSAGRRTPSP--------RRSSEGGGILKHTTGPDPGILKPPSSPAKSKS 2422
             ..|.|    .|..:||.....|.|        ..:|...|.:|....| |.|  ||..|...|.
Human  1129 -FFSSC----GSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDP-PAI--PPRQPPPPKV 1185

  Fly  2423 PDRSCLKKG---GPSHVCSVETLSPRVSPRGSMDHLSPDRGMTSS----SC---LRHSPRSSFDS 2477
            ..|..:..|   ||.|      ..|...||..:....|...:...    :|   |:..|....  
Human  1186 KPRVPVPTGAFDGPLH------SPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHL-- 1242

  Fly  2478 HGESDHNLDVPHGSRKRSMSAHGSFETGTRPRAQETYQYYPVYDNQTCSDHYVAAAPTGRYGGGT 2542
            |.:||...|:                                   .||.:               
Human  1243 HRDSDWLRDI-----------------------------------STCPN--------------- 1257

  Fly  2543 SSRSRLSKSLERSTSRDSTTTSSSYGHRAYGVSPDRNYVVFSSG---PLRSQSAENTFSSQPIYD 2604
                        |.|...:|.|.....|.|.:|..:|.:.....   |.|..|:.:         
Human  1258 ------------SPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPH--------- 1301

  Fly  2605 PLPRHPP----QPLHQPPMH 2620
             ||:.||    :.|..||::
Human  1302 -LPKLPPKTYKRELSHPPLY 1320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 42/207 (20%)
PH2_Tiam1_2 1650..1823 CDD:269957 40/231 (17%)
PH 1693..1812 CDD:278594 29/157 (18%)
SOS2NP_008870.2 Histone 63..169 CDD:329110
RhoGEF 199..386 CDD:238091 42/214 (20%)
PH_SOS 437..543 CDD:269963 18/112 (16%)
RasGEFN 595..739 CDD:214571 22/164 (13%)
RasGEF 774..1013 CDD:238087 47/277 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1018..1061 9/44 (20%)
NupH_GANP <1023..>1142 CDD:318883 34/151 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1076..1096 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1142..1332 48/262 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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