DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and SOS1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_005624.2 Gene:SOS1 / 6654 HGNCID:11187 Length:1333 Species:Homo sapiens


Alignment Length:1401 Identity:267/1401 - (19%)
Similarity:446/1401 - (31%) Gaps:495/1401 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1439 VSTTALTPSRQLTDAEK----LRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNA----- 1494
            ::..:||.....|..|:    |.|..|..:   |.|::.||.:::.:.||     |:||:     
Human   183 INILSLTDEEPSTSGEQTYYDLVKAFMAEI---RQYIRELNLIIKVFREP-----FVSNSKLFSA 239

  Fly  1495 -EINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAF--LYYVNHFKL 1556
             ::..:|..|.:|.....:.|.::|:::::..:.:...          .:||.|  |.....|..
Human   240 NDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHP----------LVGSCFEDLAEELAFDP 294

  Fly  1557 YSSFCASHSKAQKVLHPNEGNHALQEFLAARNP--------------KQQHSSTLESYLIKPIQR 1607
            |.|:      |:.:|.|  |.|  ..||:..:.              |:.....|...|:.|:..
Human   295 YESY------ARDILRP--GFH--DRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYH 349

  Fly  1608 ILKYPLLLQQMRNLTDTRADEHVHLCEALK-----------GMEKVAEHINEMQRIHEEYGAIFD 1661
            .|.|..||:|:...::.:.|:     |.||           ||||:.......:|:.|.....:.
Human   350 CLHYFELLKQLEEKSEDQEDK-----ECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYS 409

  Fly  1662 HLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGK---------IKKGL--------ELHAM 1709
            ...:..|.:.|:..::..            ||..:.||         |.:|.        |.|..
Human   410 QQMKGKQLAIKKMNEIQK------------NIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIF 462

  Fly  1710 CFVFKSAVVFLCKE---------------RLRQK--KKLMGVSSKNATNEVEIIRYQVLIPVTEV 1757
            .|   ..::..||.               ||::|  .:.:.::.|:.|||.:.....:|.....|
Human   463 LF---DGLMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSV 524

  Fly  1758 QVRASSAKDMDSHFLWELIHL--RSQLQR-------RSEKVYVLSNSTAD-FRNAFLKTIRQIIR 1812
            ...|.||:: .::::..||.|  ||.|:|       :.||...:...:|| :|.|...:...||.
Human   525 IFSAKSAEE-KNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIF 588

  Fly  1813 ESVRNM----SIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLER----PKQQITIVHGSHTLG 1869
            |  .||    .||:...|.....:...:........:.....|..|    |::.::::.....:.
Human   589 E--ENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIP 651

  Fly  1870 KPKK--------KSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVV----HYASGHTHG------- 1915
            :|:.        ::|.|..||      .|...::....|..:.|:    |:...|.:.       
Human   652 EPEPTEADRIAIENGDQPLSA------ELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYL 710

  Fly  1916 -QQMQP--AGFRGRS--KTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPRE 1975
             |:|:.  ...||::  |.|..:|:|.              |:::.....|..|       :...
Human   711 LQRMEEFIGTVRGKAMKKWVESITKII--------------QRKKIARDNGPGH-------NITF 754

  Fly  1976 PPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTG 2040
            ...||..:.|:..                                  |.|:......||......
Human   755 QSSPPTVEWHISR----------------------------------PGHIETFDLLTLHPIEIA 785

  Fly  2041 SQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARD 2105
            .|..|::|.    .|:.|...:|......:.:.|..|......:..:.||:|.....:..::..:
Human   786 RQLTLLESD----LYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLE 846

  Fly  2106 NQTQSRTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFE------SEAERLAASQQVAV---- 2160
            .:.  ...|:|                      ||::::|:      ...|.::|.....|    
Human   847 ERV--AVVSRI----------------------IEILQVFQELNNFNGVLEVVSAMNSSPVYRLD 887

  Fly  2161 --VHQHPSDQAR--ESGHKQRRD---------RDRNPTETDATARFMDKHLSDL---EQEN---L 2206
              ..|.||.|.:  |..|:...|         |..||    ....|...:|:::   |:.|   |
Human   888 HTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINP----PCVPFFGIYLTNILKTEEGNPEVL 948

  Fly  2207 TDGTCDIVAYMESLREKAFDPQDLAEDTGDHQQNDSSLSPEPQTIVENTQQTVVVDIESPSRPAT 2271
            .....:::.:  |.|.|      :||.||:.||..:              |...:.:||..:...
Human   949 KRHGKELINF--SKRRK------VAEITGEIQQYQN--------------QPYCLRVESDIKRFF 991

  Fly  2272 ESDSTGNTTGPSERSGDETEEEATTSSLASHIVVIDKKVDKIFKAKSPERPASTKVKGGRRQIYI 2336
            |:      ..|   .|:..|:|.|               |.:|.......|.:.|......:.|.
Human   992 EN------LNP---MGNSMEKEFT---------------DYLFNKSLEIEPRNPKPLPRFPKKYS 1032

  Fly  2337 SPDRCKSQGSSPVRIIKIKSPR-------TSLSDQGKRLSVCSSRDNSQDRLSAGRRTPSPRRSS 2394
            .|  .||.|..|      .:||       |.|..:.:::|.  ||....:..|......|||.. 
Human  1033 YP--LKSPGVRP------SNPRPGTMRHPTPLQQEPRKISY--SRIPESETESTASAPNSPRTP- 1086

  Fly  2395 EGGGILKHTTGPDPGILKPPSSPAKSKSPDRSCLKKGGPSHVCSVETLSPRVSPRGSMDHLSPDR 2459
                            |.||.:...|.:.|           ||||          ...||.||  
Human  1087 ----------------LTPPPASGASSTTD-----------VCSV----------FDSDHSSP-- 1112

  Fly  2460 GMTSSSCLRHSPRSSFDSHGESDH---NLDVPHGSRKRSMSA----HGSFETGTRPRAQETYQYY 2517
                             .|..:|.   .:.:|||.|..|:|:    .|:.|....|         
Human  1113 -----------------FHSSNDTVFIQVTLPHGPRSASVSSISLTKGTDEVPVPP--------- 1151

  Fly  2518 PVYDNQTCSDHYVAAAPTGRYGGGTSSRSRLSKSLERSTSRDS-------TTTSSSYGHRAYGVS 2575
            ||              |..|......:.|..||.:  |...||       ..||.:|..| |.:|
Human  1152 PV--------------PPRRRPESAPAESSPSKIM--SKHLDSPPAIPPRQPTSKAYSPR-YSIS 1199

  Fly  2576 -------------------PDRNYVVFSSGPLRSQ----------------SAENTFSSQPIYDP 2605
                               |.|...||||.||..|                ::.:.|:..|...|
Human  1200 DRTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPQTP 1264

  Fly  2606 LP----RHPPQP-------LHQ---PPMHHQQQQQQ 2627
            .|    ||.|.|       ||.   ||:..:|...|
Human  1265 SPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQ 1300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 48/223 (22%)
PH2_Tiam1_2 1650..1823 CDD:269957 47/220 (21%)
PH 1693..1812 CDD:278594 36/162 (22%)
SOS1NP_005624.2 Histone 63..169 CDD:333859
RhoGEF 204..389 CDD:214619 46/217 (21%)
PH_SOS 439..545 CDD:269963 21/109 (19%)
RasGEFN 597..741 CDD:214571 25/163 (15%)
RasGEF 776..1015 CDD:238087 56/316 (18%)
PTZ00449 <1018..1319 CDD:185628 82/376 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1019..1103 24/121 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1333 46/198 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.