DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and ARHGEF28

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001073948.2 Gene:ARHGEF28 / 64283 HGNCID:30322 Length:1731 Species:Homo sapiens


Alignment Length:2118 Identity:394/2118 - (18%)
Similarity:641/2118 - (30%) Gaps:846/2118 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   724 GSGSGHGMMTQQI---------PGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIR 779
            ||...|.|:.::|         ||.|.:.:...|:       .|...||......|         
Human    38 GSHQRHVMIAERIEDNVLQSSVPGHGLQETVTVSV-------CLCSEGYSPVTMGS--------- 86

  Fly   780 QDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRM------------SLTTAVSD 832
                                 .|:...|:..|.|....::..:|:            :||.....
Human    87 ---------------------GSVTYVDNMACRLARLLVTQANRLTACSHQTLLTPFALTAGALP 130

  Fly   833 EDDGESVMASPY---KAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWV 894
            ..|.|.|:|..:   ..:.|...:||.. ..:.|::......:|.|.|..|           :::
Human   131 ALDEELVLALTHLELPLEWTVLGSSSLE-VSSHRESLLHLAMRWGLAKLSQ-----------FFL 183

  Fly   895 CLK-GTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQ--- 955
            ||. |...|..|  :.||    |.|..|.:.:|        |.|         ...|...||   
Human   184 CLPGGVQALALP--NEEG----ATPLDLALREG--------HSK---------LVEDVTNFQGRW 225

  Fly   956 ----APCQVELENWVNSIHSACAAAFARHRGKTGTL-------HLLQEEI--FR--------LEK 999
                :..|:..|..::.|||:          :|.||       |||:.:|  ||        |.|
Human   226 SPSFSRVQLSEEASLHYIHSS----------ETLTLTLNHTAEHLLEADIKLFRKYFWDRAFLVK 280

  Fly  1000 AIESDHKLKHMAELQQS-VVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNP 1063
            |.|.:.:.:....:..| ..|::|.::.:.::....:|:::|:                      
Human   281 AFEPEARPEERTAMPSSGAETEEEIKNSVSSRSAAEKEDIKRV---------------------- 323

  Fly  1064 KSLLT-HVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSR 1127
            |||:. |.....:::|:     ...||.....::.||.|  |.||                   |
Human   324 KSLVVQHNEHEDQHSLD-----LDRSFDILKKSKPPSTL--LAAG-------------------R 362

  Fly  1128 RSMQMNSRDE-----------------------------PEKTFKVAMPDNAYSTVYLRDAMSV- 1162
            .|..:|..||                             ||.......|.::..|:....:.|| 
Human   363 LSDMLNGGDEVYANCMVIDQVGDLDISYINIEGITATTSPESRGCTLWPQSSKHTLPTETSPSVY 427

  Fly  1163 ---------------EEFL--ASACARRNLN----------PMEHFVRVKKRRDMEDHNYFVPHR 1200
                           :.|:  :|:|| .|||          ...|   :|||....|        
Human   428 PLSENVEGTAHTEAQQSFMSPSSSCA-SNLNLSFGWHGFEKEQSH---LKKRSSSLD-------- 480

  Fly  1201 NDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSV 1265
                                                 :::|:.......:....||....:..| 
Human   481 -------------------------------------ALDADSEGEGHSEPSHICYTPGSQSSS- 507

  Fly  1266 AMHNGIIKGDEIMVINGAIVSDLDMMYLESV-----LQEEQSLSMMMRS---SRTEPPDLVGIMR 1322
              ..||..|||:.........|.::...||:     ||.::||...:||   |.:.|...:|..|
Human   508 --RTGIPSGDELDSFETNTEPDFNISRAESLPLSSNLQSKESLLSGVRSRSYSCSSPKISLGKTR 570

  Fly  1323 VTDDMIDSLVC-----------PPPPTDPPVMSEEMITGLIVP---------------------- 1354
            :..::   .||           ..||.:..:..||. ...|:|                      
Human   571 LVREL---TVCSSSEEQRAYSLSEPPRENRIQEEEW-DKYIIPAKSESEKYKVSRTFSFLMNRMT 631

  Fly  1355 ------------------------APG-WNGT------SKDLYSPEA---------------ESS 1373
                                    ||| ::|.      .|.|...|:               :::
Human   632 SPRNKSKTKSKDAKDKEKLNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAA 696

  Fly  1374 PA--------------------TSFVD---PAAMAAQLAVGGVGGVVVG-------GLGVAKPTS 1408
            ||                    :||.|   |.     |::.....|.||       .:|...|.|
Human   697 PACTKKFQEKYNKNKPQTILGNSSFRDIPQPG-----LSLHPSSSVPVGLPTGRRETVGQVHPLS 756

  Fly  1409 RT-------------SSFEIENLLKTAEQETRK--------SSPT-----------GSVTSSVST 1441
            |:             :|.|.|:...:....:..        |||:           .|:.|.:|:
Human   757 RSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDLSS 821

  Fly  1442 TA-----------LTPS---RQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLS 1492
            .|           :.||   ||..|..|.:.|:.||:.||..:::.|..:.|.:.:.||.|..|.
Human   822 DAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLD 886

  Fly  1493 NAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHC-GQFRN-VLFAIGSAFLYYVNHF- 1554
            ::.::.:|..:.|::...|.|..:::|        .:.|.| |..|| |:..||...   |..| 
Human   887 HSTVDKIFPCLDELLEIHRHFFYSMKE--------RRQESCAGSDRNFVIDRIGDIL---VQQFS 940

  Fly  1555 --------KLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPK-QQHSSTLESYLIKPIQRILK 1610
                    |:|..||..|.:|..:....:.|...|.|:..||.. ......:...::...|||.|
Human   941 EENASKMKKIYGEFCCHHKEAVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITK 1005

  Fly  1611 YPLLLQQMRNLTDTRADEHVHLCEAL---KGM--------------EKVAEHINEMQRIHEEYGA 1658
            ||:|::::...|..|.:||..|.:||   |.|              :|..|.:|:::  ::.|..
Human  1006 YPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIE--NKTYTK 1068

  Fly  1659 IFD-HLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCK 1722
            :.: |:||      ||.:......|||.|.|.|...:   |:.|..|.|     :....::||  
Human  1069 LKNGHVFR------KQALMSEERTLLYDGLVYWKTAT---GRFKDILAL-----LLTDVLLFL-- 1117

  Fly  1723 ERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQ--------VRASSAKDMDSHFLWELIHLR 1779
            :...||.....|..|.:     :|..|.|| ..||.        :.||||               
Human  1118 QEKDQKYIFAAVDQKPS-----VISLQKLI-AREVANEERGMFLISASSA--------------- 1161

  Fly  1780 SQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMG 1844
                  ..::|.:..::.:.||.:::.|:|.:...                              
Human  1162 ------GPEMYEIHTNSKEERNNWMRRIQQAVESC------------------------------ 1190

  Fly  1845 YPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYA 1909
                                      |::|.|.               :.|:|:           
Human  1191 --------------------------PEEKGGR---------------TSESDE----------- 1203

  Fly  1910 SGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQ-----QQQQQQQQLMQQGHAHA---- 1965
                           .:.|....|.:|        ||.|     |.||....|.::.|.:|    
Human  1204 ---------------DKRKAEARVAKI--------QQCQEILTNQDQQICAYLEEKLHIYAELGE 1245

  Fly  1966 -------HPHPH----PHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPK--- 2016
                   |..||    |.|.|||.   ....|.....:.|.:....|:     ||.|.:...   
Human  1246 LSGFEDVHLEPHLLIKPDPGEPPQ---AASLLAAALKEAESLQVAVKA-----SQMGAVSQSCED 1302

  Fly  2017 ----ATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVL----MKDLGK-------P 2066
                :.|..|.:...:..:.|.|:.:.|.:.|......|  ..|.|:    :.|.|:       |
Human  1303 SCGDSVLADTLSSHDVPGSPTASLVTGGREGRGCSDVDP--GIQGVVTDLAVSDAGEKVECRNFP 1365

  Fly  2067 SPDESEL---------------------ESESEVHAAQVAASFNLSLGSS----GSLFASDARDN 2106
            ...:||:                     :|..|:|...:.....||||.|    |.|....:||.
Human  1366 GSSQSEIIQAIQNLTRLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDA 1430

  Fly  2107 QTQSRTQSQIHSLHPSPRQSPRQSPRQSPKQD--IEVIEIFESEAERLAASQQVAVV-------- 2161
            ..|....:.:|.|....:|..|:..|:..:|.  ....|.:..|.||...||:..::        
Human  1431 DRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDL 1495

  Fly  2162 ----HQHPSDQARESGHKQRRDRDRNPTETDATARFMDKHLSDLEQENLTDGTCDIVAYMESLRE 2222
                :||..::.||......|::.|...:......:.......|....|..|.    ..||..|.
Human  1496 QLQEYQHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSLPAVLLPGGP----EVMELNRS 1556

  Fly  2223 KAFDPQDLAEDTGDHQQNDSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTTGPSERSG 2287
            :                   ||..|....:..    .:|.:         |.:|.|...||    
Human  1557 E-------------------SLCHENSFFINE----ALVQM---------SFNTFNKLNPS---- 1585

  Fly  2288 DETEEEATTSSLASHIVV-------IDKKVDKIFKAKSPERPASTKVK-----GGRRQIY----I 2336
             ...::||..:..||..:       :|.|||       |.:|::...|     |...||.    .
Human  1586 -VIHQDATYPTTQSHSDLVRTSEHQVDLKVD-------PSQPSNVSHKLWTAAGSGHQILPFHES 1642

  Fly  2337 SPDRCKSQGSSPVRIIKIKSPRTSLSDQGKRLSVCSSRDNSQDRLSAGRRTPSPRRSSEGGGILK 2401
            |.|.||:                     |..::.||....|...|..|  |.|..:..:    ..
Human  1643 SKDSCKN---------------------GSSMTKCSCTLTSPPGLWTG--TTSTLKDLD----TS 1680

  Fly  2402 HTTGPDP-------GILKPPSSPAKSKSPDRSCLKKGG 2432
            ||..|.|       ..|:...:.||...|.|:..::.|
Human  1681 HTESPTPHDSNSHRPQLQAFITEAKLNLPTRTMTRQDG 1718

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 26/132 (20%)
PH 873..974 CDD:278594 25/108 (23%)
TIAM1_RBD 1141..1219 CDD:176413 16/105 (15%)
PDZ_signaling 1221..1308 CDD:238492 16/91 (18%)
RhoGEF 1456..1647 CDD:238091 55/219 (25%)
PH2_Tiam1_2 1650..1823 CDD:269957 37/181 (20%)
PH 1693..1812 CDD:278594 25/126 (20%)
ARHGEF28NP_001073948.2 ANK <153..216 CDD:295348 20/97 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..316 3/28 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 473..524 13/98 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 630..649 0/18 (0%)
C1 653..698 CDD:237996 7/44 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 710..800 16/94 (17%)
RhoGEF 853..1042 CDD:214619 53/199 (27%)
PH_p190RhoGEF 1087..1187 CDD:275430 31/136 (23%)
PH <1123..1188 CDD:278594 18/91 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1187..1207 5/116 (4%)
Interaction with PTK2/FAK1, required for regulation of axonal branching and synapse formation. /evidence=ECO:0000250 1295..1304 0/8 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1312..1339 5/26 (19%)
Mediates cytoplasmic retention and interaction with YWHAH. /evidence=ECO:0000250 1372..1383 0/10 (0%)
RNA-binding. /evidence=ECO:0000250 1496..1527 6/30 (20%)
Mediates cytoplasmic retention and interaction with MAPK8IP1. /evidence=ECO:0000250 1566..1579 2/25 (8%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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