DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and Arhgef26

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_001074764.1	Gene:	Arhgef26 / 622434	MGIID:	1918053	Length:	869	Species:	Mus musculus

Alignment Length:	942	Identity:	171/942 - (18%)
Similarity:	304/942 - (32%)	Gaps:	318/942 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1060 LPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLN----NLLAGRGATK-------- 1112
            ||.|::.:...:.|...|:                :|||.||:    .:..||..:.
Mouse    58 LPTPQTPVRVPADPDDRTV----------------SRSPQLLSAHRRPVTNGRTVSPDYRAASPR 106

  Fly  1113 -RRP--PMLSRSNSGSSRRSMQMNSRDEPEKTFKVA--MPDNAYSTVYLRD-----AMSVEEFLA 1167
             |||  |::|.:.||.|.:|....:...|......|  .||...|.....|     |..|...:|
Mouse   107 LRRPKSPLVSYAASGGSPKSTSNGTVASPAALLSRASRTPDTPASCATDEDCTGVTASKVSSPIA 171

  Fly  1168 SACARR----------------------NLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIE----- 1205
            :..|.:                      .|:|.                  :||::...:
Mouse   172 NGLAHKTDSSGPVSQTGQPAGDLELAPSRLSPA------------------LPHKSSEQKLPLQR 218

  Fly  1206 -----NYLHNHEFV-----EVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRV 1260
                 |.|.|...|     ...:|:..|..:.::...::   .:.....:|.|....|....|.|
Mouse   219 LPSQGNELPNPSVVLSTNSPAALKMGKQQIIPKSLASEI---KLSKSNSQNVESHRRLLKVRSMV 280

  Fly  1261 EDKSVAMHNGIIKGDEIMVINGAIVSDLD-----------MMYLESVLQ--EEQSLSMMMRSSRT 1312
            |.....:.:   :|:|     |.:.:|:|           ..|..:|:.  :..|.:...:.:|.
Mouse   281 EGLGAPLGH---EGEE-----GEVDNDMDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSKKKNRM 337

  Fly  1313 EPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGL--------IVPAPGWNGTSKDLYS-- 1367
            ..|.|..:|. ..:...||         ..:.::::.|.        .|....:...:.|:.|
Mouse   338 SQPVLKAVME-DKEKFSSL---------GRIKKKILKGQGTFDGEENAVLYQNYKEKALDIDSDE 392

  Fly  1368 -PEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSP 1431
             |||:...|..                 .:|:....:....|:.|:.:...|.:|..||.||
Mouse   393 EPEAKEQKAEE-----------------RIVIHHKPLRSTWSQLSAVKRNGLSQTVSQEERK--- 437

  Fly  1432 TGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEI 1496
                            ||        :.:.|::.:|.:|:..|..|:..:....:....::..|.
Mouse   438 ----------------RQ--------EAIFEVISSEHSYLLSLEILIRMFKNSKELTDTMTKTER 478

  Fly  1497 NALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFL---YYVNHFKLYS 1558
            :.||.||.::....::|...||               .:.:|.:|....:.:   :..:.|..|.
Mouse   479 HHLFSNITDVWEASKKFFTELE---------------ARHQNNIFIEDISDIVEKHTASTFDPYV 528

  Fly  1559 SFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLE-----------SYLIKPIQRILKYP 1612
            .:|.:....|:         .||:.||.....::..|.:|           |:||.|:||:.:.|
Mouse   529 KYCTNEVYQQR---------TLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLP 584

  Fly  1613 LLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINE----MQRIHEEYGAIFDHLFRQHQKSCKQ 1673
            ||:..:...|...:.::.....|||.:.|:....||    |:|....|..           :.:.
Mouse   585 LLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTI-----------NSQL 638

  Fly  1674 PIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQK------KKLM 1732
            ...:.|..|:  ....||        :|:| ||.|    :....|...|...:|:      ..::
Mouse   639 EFKIKPFPLV--SSSRWL--------VKRG-ELTA----YVEDTVLFSKRMSKQQVYFFLFNDVL 688

  Fly  1733 GVSSKNATNEVEI----IRYQVLI---------------PVTEVQVRASSAKDMDSHFLWELIHL 1778
            .::.|.:.....:    :|.|:|:               |.|.:..|.|||    :|    |..|
Mouse   689 IITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNPSTMLYSRQSSA----TH----LFTL 745

  Fly  1779 RSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSM 1843
            .......||||.:|..:......|     |.|                    :..||||   |..
Mouse   746 TVLSNHASEKVDMLLGAETQSERA-----RWI--------------------TALGHSS---GKQ 782

  Fly  1844 GYPGNSQTLERPKQQITIVHGSHTLGKPKKKS 1875
              |.:..||    .|:.|:. |.|..:|.:.|
Mouse   783 --PPDRTTL----TQVEIIR-SFTAKQPDELS 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413	17/121 (14%)
		PDZ_signaling	1221..1308	CDD:238492	15/99 (15%)
		RhoGEF	1456..1647	CDD:238091	39/204 (19%)
		PH2_Tiam1_2	1650..1823	CDD:269957	35/197 (18%)
		PH	1693..1812	CDD:278594	29/143 (20%)
Arhgef26	NP_001074764.1	RhoGEF	441..620	CDD:279015	39/202 (19%)
		PH_ephexin	641..779	CDD:269929	35/185 (19%)
		SH3_ARHGEF16_26	791..845	CDD:212871	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910