Protein Alignment sif and arhgef3.1

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: NP_001027503.1
• Gene: arhgef3.1 / 613095
• XenbaseID: XB-GENE-5940983
• Length: 526
• Species: Xenopus tropicalis
• Alignment Length: 536
• Identity: 115/536 - (21%)
• Similarity: 197/536 - (36%)
• Gaps: 122/536 - (22%)

  Fly  1341 PVMSEEMIT--------GL-----IVPAPGWNGTSKDLYSP---------EAESSPATSFVDP-- 1381
            ||..|...|        ||     :.|.||.....|:..|.         .|..:|..:.|.|
 Frog    36 PVQRERSYTSGSLSESSGLKRRKQVEPPPGQVAEEKEPSSKRVKPVSKTLSASGAPPPAKVTPLK 100

  Fly  1382 -AAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVS----T 1441
             .:::.|.::|            .|..||..||         ...||...|.|......|    .
 Frog   101 KLSLSIQKSIG------------CKSESRLFSF---------PPRTRSREPGGGAKRRSSKLWRE 144

  Fly  1442 TALTPSRQLTDAE-KLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHE 1505
            |..:...:|:..| |.::|:.||:..|.|.::.||.:.::|.|||.:...||..|:..:||.:..
 Frog   145 TFDSAGEELSAREIKRQEVIFELMQGEHTLIEDLNLVRKNYYEPMLKLEILSREELEQIFGILDS 209

  Fly  1506 IVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKV 1570
            :....:..|:.|.: |.||.            ..|..||...|.::.....|.::|.:...|:.:
 Frog   210 LAPLHQDLLERLLK-LRLED------------GTLEVIGPTMLEWLPCLHAYKTYCCNQVAAKSL 261

  Fly  1571 LHPNEGNHALQEFLAARNPKQQHSSTLE--SYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLC 1633
            |.......|:|.||.... :...|..|:  |:|..|..|::||||||:::...|.....::..|.
 Frog   262 LDHKRRCAAVQNFLRLCQ-ESAFSRKLDVWSFLDLPRSRLVKYPLLLKELLKHTGPEHPDYTPLG 325

  Fly  1634 EALKGMEKVAEHINEM--QRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDF 1696
            ||:..::.:...||..  :...|.|.....:|:...::                |.|....:...
 Frog   326 EAVCMIQTIVSLINSKTGEAECEYYRRRLTYLYESQEE----------------GAVTSSRLLHC 374

  Fly  1697 LGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVL--------IP 1753
            .|::|.........|:|::|:|            |....::|...:.::.|..:.        :|
 Frog   375 HGELKNNKGQRLQVFLFEAALV------------LTRPITQNHQLQFQVYRQPIPLQELVLEDLP 427

  Fly  1754 VTEVQVRAS------SAKDMDSHFLWELIHLRSQLQRRSE-KVYVLSNSTADFRNAFLKTIRQII 1811
            ..||:|..|      .|.:...:|      .|...|.||. :.:.|..:.:..:..::..|||..
 Frog   428 DGEVRVGGSIRGAFTPATERAKNF------FRVSFQDRSRGQSHTLQANDSFNKQQWVSCIRQAK 486

  Fly  1812 RESVRNMSIPMKNFGG 1827
            ..:.|..:.|    ||
 Frog   487 AANQRGSTSP----GG 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	49/192 (26%)
		PH2_Tiam1_2	1650..1823	CDD:269957	31/187 (17%)
		PH	1693..1812	CDD:278594	24/133 (18%)
arhgef3.1	NP_001027503.1	RhoGEF	163..339	CDD:214619	49/189 (26%)
		PH_RhoGEF3_XPLN	353..486	CDD:269976	27/166 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910