Protein Alignment sif and Arhgef1

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: XP_038944848.1
• Gene: Arhgef1 / 60323
• RGDID: 620951
• Length: 979
• Species: Rattus norvegicus
• Alignment Length: 550
• Identity: 126/550 - (22%)
• Similarity: 213/550 - (38%)
• Gaps: 120/550 - (21%)

  Fly  1423 EQETRKSSPTGSVTSSVSTTAL-TPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMK 1486
            |||..:  |.|......|.|.| .|..|:    |.::|:.||:.||..:|:.|..|.:.:.:||.
  Rat   447 EQEPEE--PPGWRELVPSDTLLGLPKNQV----KRQEVISELLVTEAAHVRMLRVLHDLFYQPMA 505

  Fly  1487 RETFLSNAEINALFGNIHEIVTFQRQFLQNL----EESLDLEPDFNKFEHCGQFRNVLF--AIGS 1545
            ...|....|:..:|.::.|::.....||..|    :||..|      .|..|......|  |.||
  Rat   506 EGGFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL------IEEIGDVLLARFDGAEGS 564

  Fly  1546 AFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHA-----LQEFLAARNPKQQHSSTLESYLIKPI 1605
            .|.      |:.|.||:..|.|.:.|...:....     :||  |...|:.:... |:..:...:
  Rat   565 WFQ------KISSRFCSRQSFALEQLKAKQRKEPRFCAFVQE--AESRPRCRRLQ-LKDMIPTEM 620

  Fly  1606 QRILKYPLLLQQMRNLTDTRADE-HVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFR---Q 1666
            ||:.|||||||.:...|:..|:. .|.|  |.:...::..|:|:..|..|:...:.|:..|   .
  Rat   621 QRLTKYPLLLQSIGQNTEEPAERAKVEL--AAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLT 683

  Fly  1667 HQKSCKQP-------IDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKER 1724
            |.:....|       :|::...|::.|.:.|....|      |.:|:|          |.|..:.
  Rat   684 HLRQSNDPMLSEFKNLDITKKKLVHEGPLTWRLTKD------KAVEVH----------VLLLDDL 732

  Fly  1725 L----RQKKKLMGVSSKNATNEVEIIRYQVLIPV---TEVQVR--ASSAKDMDSHFLWELIHLRS 1780
            |    ||.::|: :.|.:.|.........:|.||   |....|  |:..|.....|.|:
  Rat   733 LLLLQRQDERLL-LKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVIFTWD------ 790

  Fly  1781 QLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPM-----KNFGGSSGS----VSGHS 1836
                :..::|.|...|:..|.::.    .:|.|:..::.:|.     |.....|.:    :|...
  Rat   791 ----QEAQIYELVAQTSSERKSWC----ALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSE 847

  Fly  1837 SQGMGSMGYPGNSQTLER------------PKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDN 1889
            :...|:...|.:::| ||            |:.|:.        ....:|..|.:....:.:.|:
  Rat   848 NGTGGTEAAPADART-ERILNDLLPFCRPGPEGQLA--------ATALQKVLSLKQILLSTEEDS 903

  Fly  1890 LSGSQEADDLPPSVGVVHYASGHTHGQQMQ 1919
            .:|.....|..|..|    |.|.||.|:::
  Rat   904 GAGPPRDGDGVPGGG----APGPTHTQEVE 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	54/202 (27%)
		PH2_Tiam1_2	1650..1823	CDD:269957	38/196 (19%)
		PH	1693..1812	CDD:278594	25/127 (20%)
Arhgef1	XP_038944848.1	RGS_p115RhoGEF	50..242	CDD:188709
		RhoGEF	478..662	CDD:214619	54/200 (27%)
		PH_p115RhoGEF	696..820	CDD:275429	31/154 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910