DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and RASGRF2

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_008840.1 Gene:RASGRF2 / 5924 HGNCID:9876 Length:1237 Species:Homo sapiens


Alignment Length:1123 Identity:199/1123 - (17%)
Similarity:339/1123 - (30%) Gaps:436/1123 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  1156 LRDAMSVEEFLASACARRNLNPMEHFVRVKKRRD----ME-----DHNYFVPHRNDLIENYLHNH 1211
            :|||:..:.:...........|:|  :|.::.:|    ||     .:...:..|..|::.|:|..
Human    89 VRDALDKQYYFTVLFGHEGQKPLE--LRCEEEQDGKEWMEAIHQASYADILIEREVLMQKYIHLV 151

  Fly  1212 EFVE----VCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGII 1272
            :.||    ...::.:|:|.|.|.:|::     ::|:|...:.::.:..|.|..||          
Human   152 QIVETEKIAANQLRHQLEDQDTEIERL-----KSEIIALNKTKERMRPYQSNQED---------- 201

  Fly  1273 KGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPP 1337
                                                    |.||:..|.:|              
Human   202 ----------------------------------------EDPDIKKIKKV-------------- 212

  Fly  1338 TDPPVMSEEMITGLIVPAPGWNGTSKD-LYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGL 1401
                   :..:.|.:.... |....:| :.||.|||                             
Human   213 -------QSFMRGWLCRRK-WKTIVQDYICSPHAES----------------------------- 240

  Fly  1402 GVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDT 1466
                                                               ..|..::|..:|:.
Human   241 ---------------------------------------------------MRKRNQIVFTMVEA 254

  Fly  1467 ERTYVKHLNNLLEHYLEPMK-----RETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPD 1526
            |..||..|..|:..:|.|::     ::..:|:.:::::|.|...|:.....|.|.|:..:...|.
Human   255 ESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARIANWPT 319

  Fly  1527 FNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLA--ARNP 1589
            .           :|..:....|..:|   :|..|..:|..:.:||...:.|....:.|.  ..||
Human   320 L-----------ILADLFDILLPMLN---IYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANP 370

  Fly  1590 KQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRI-H 1653
            ..: ...||::|..|:.:|.:|.:.|.::  |..| ..|||.    .|.:|.....:.|:.|: |
Human   371 ACE-GRMLETFLTYPMFQIPRYIITLHEL--LAHT-PHEHVE----RKSLEFAKSKLEELSRVMH 427

  Fly  1654 EEYGAIFD--------HLFRQHQKSCKQPIDLS-----PGDLLYYGGVEWLNISDF-LGKIKKGL 1704
            :|   :.|        .:.|...:.|...:|.|     .|.|:....||...:|.. ||.:....
Human   428 DE---VSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKK 489

  Fly  1705 ELHAMCFVFKSAVVFLCKERLRQKKKLM---GVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKD 1766
            |....||:|....: :|......|..|:   ||.|              ||..|.::  ...|.|
Human   490 EGERQCFLFTKHFL-ICTRSSGGKLHLLKTGGVLS--------------LIDCTLIE--EPDASD 537

  Fly  1767 MDSHFLWELI-HLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSG 1830
            .||....::. ||       ..|:.|.....|.|....|...||   |....||       ..|.
Human   538 DDSKGSGQVFGHL-------DFKIVVEPPDAAAFTVVLLAPSRQ---EKAAWMS-------DISQ 585

  Fly  1831 SVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQE 1895
            .|......|:.::.:..||        ::|:.|        ..||.::.|.    |..::..|:.
Human   586 CVDNIRCNGLMTIVFEENS--------KVTVPH--------MIKSDARLHK----DDTDICFSKT 630

  Fly  1896 ADDLPPSVGVVHYASG----------------------HTHGQQMQPAGFRGRSKTVGDVTEITC 1938
            .:..  .|..:.|||.                      ||:      ..|...:..:|.:::|  
Human   631 LNSC--KVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTY------RIFTTAAVVLGKLSDI-- 685

  Fly  1939 SSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSE 2003
                                             :.|.....|:|...|...:|...|        
Human   686 ---------------------------------YKRPFTSIPVRSLELFFATSQNNR-------- 709

  Fly  2004 GEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQ--SSHPPASY----QPVLMKD 2062
            ||                   ||.           .|...||.:  ||.||.:.    .||..:.
Human   710 GE-------------------HLV-----------DGKSPRLCRKFSSPPPLAVSRTSSPVRARK 744

  Fly  2063 LGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQ-- 2125
            |...||..|::            .:.:|:..||.:            :.|||...|..|...|  
Human   745 LSLTSPLNSKI------------GALDLTTSSSPT------------TTTQSPAASPPPHTGQIP 785

  Fly  2126 --------SPRQSPR------QSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHKQ 2176
                    ||.|||.      .:|:.|:         ..:|..|.|.||:...|:|:|.......
Human   786 LDLSRGLSSPEQSPGTVEENVDNPRVDL---------CNKLKRSIQKAVLESAPADRAGVESSPA 841

  Fly  2177 RRDRDRNPTETDATARFM 2194
            ....:.:|..:.:|.|.:
Human   842 ADTTELSPCRSPSTPRHL 859

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413 15/75 (20%)
PDZ_signaling 1221..1308 CDD:238492 11/86 (13%)
RhoGEF 1456..1647 CDD:238091 43/197 (22%)
PH2_Tiam1_2 1650..1823 CDD:269957 44/191 (23%)
PH 1693..1812 CDD:278594 29/123 (24%)
RASGRF2NP_008840.1 PH_RasGRF1_2 19..158 CDD:270081 15/70 (21%)
RhoGEF 247..428 CDD:214619 45/202 (22%)
PH 480..588 CDD:214574 32/141 (23%)
RasGEF_N 638..>686 CDD:306971 8/88 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 710..809 31/152 (20%)
Regulates proteasomal degradation. /evidence=ECO:0000250 744..752 3/7 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 829..873 6/31 (19%)
RasGEFN <901..972 CDD:214571
RasGEF 998..1234 CDD:214539
Responsible of the affinity for farnesylated versus geranylgeranylated Ras. /evidence=ECO:0000250 1099..1128
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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