DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and RASGRF1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_002882.3 Gene:RASGRF1 / 5923 HGNCID:9875 Length:1273 Species:Homo sapiens


Alignment Length:1211 Identity:214/1211 - (17%)
Similarity:388/1211 - (32%) Gaps:436/1211 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1283 AIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEM 1347
            |::.:| :.|.||             .|.:.|..|.        :::..||...|:..|.:|.: 
Human    45 ALLQNL-LFYFES-------------DSSSRPSGLY--------LLEGCVCDRAPSPKPALSAK- 86

  Fly  1348 ITGLIVPAPGWNGTSKDLYSP-EAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTS 1411
                               .| |.:.....:|......|.:|..............:|..:.||.
Human    87 -------------------EPLEKQHYFTVNFSHENQKALELRTEDAKDCDEWVAAIAHASYRTL 132

  Fly  1412 SFEIENLL-------------KTAEQETRKSSPTG---------SVTSSV-------STTALTPS 1447
            :.|.|.|:             ||..::.|:....|         .:||.:       ||..:.|:
Human   133 ATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITSLLKDNERIQSTQTVAPN 197

  Fly  1448 RQLTDAEKLRK-----------------------------------VVMELVDTERTYVKHLNNL 1477
            .:.:|.:|::|                                   ||..:::.|..||:.|:.|
Human   198 DEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHIL 262

  Fly  1478 LEHYLEPMK-----RETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFR 1537
            :.::|.|::     ::..:::.:::::|.|...|:...:.|.|.|:..:...|..          
Human   263 VNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQIFYQGLKARISSWPTL---------- 317

  Fly  1538 NVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQ-HSSTLESYL 1601
             ||..:....|..:|   :|..|..:|..:.::|...:.|....:.|.....|.. ...|||::|
Human   318 -VLADLFDILLPMLN---IYQEFVRNHQYSLQILAHCKQNRDFDKLLKHYEAKPDCEERTLETFL 378

  Fly  1602 IKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRI-HEEYGAIFD---- 1661
            ..|:.:|.:|.|.|.::  |..| ..|||.    ...::.....:.|:.|| |:|.....:    
Human   379 TYPMFQIPRYILTLHEL--LAHT-PHEHVE----RNSLDYAKSKLEELSRIMHDEVSETENIRKN 436

  Fly  1662 -HLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKG--------LELHAMCFVF---- 1713
             .:.|...:.|:..:|.|. ..:..|.:..:.:|: .|||.:|        .|....||:|    
Human   437 LAIERMIIEGCEILLDTSQ-TFVRQGSLIQVPMSE-KGKITRGRLGSLSLKKEGERQCFLFSKHL 499

  Fly  1714 --------------KSAVVFL-------------------------------------------- 1720
                          |:.|:.|                                            
Human   500 IICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSGQDIDHLDFKIGVEPKDSPPFTVIL 564

  Fly  1721 -----------------CKERLRQKKKLMGVSSKNA--------------TNEVEIIRYQVLIPV 1754
                             |.:.:|....:|....:|:              |.|.|:.|....:..
Human   565 VASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENSKVTVPQMIKRTREGTREAEMSRSDASLYC 629

  Fly  1755 TEVQVRASSAKDMDSHFLWELIHLR-SQLQRRSEKVYVLSNSTADFRNAFL-------------- 1804
            .:|.:|.|  |.|:|   .:::.:| :.::|..|::..|...:.||.|.||              
Human   630 DDVDIRFS--KTMNS---CKVLQIRYASVERLLERLTDLRFLSIDFLNTFLHSYRVFTTAIVVLD 689

  Fly  1805 -------KTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLER-----PKQ 1857
                   |.|..|....:|::.:..         .||.:::.:  .|.|..|....|     |..
Human   690 KLITIYKKPISAIPARWLRSLELLF---------ASGQNNKLL--YGEPPKSPRATRKFSSPPPL 743

  Fly  1858 QITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAG 1922
            .||            |.|...|....:::...::|.:..|....|.....|.|.::   .|.|. 
Human   744 SIT------------KTSSPSRRRKLSLNIPIITGGKALDLAALSCNSNGYTSMYS---AMSPF- 792

  Fly  1923 FRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLH 1987
                ||...|.:::..||           ....::..:|..        .|.:|..|..    |.
Human   793 ----SKATLDTSKLYVSS-----------SFTNKIPDEGDT--------TPEKPEDPSA----LS 830

  Fly  1988 HHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPP 2052
            ..||::...:.....:.:.|.           |.|....|.|.|:..||.:..|      |..|.
Human   831 KQSSEVSMREESDIDQNQSDD-----------GDTETSPTKSPTTPKSVKNKNS------SEFPL 878

  Fly  2053 ASY-QPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQI 2116
            .|| ..|:|         .|..|.::...|...|::|  ::.::|   |::...|:.:.|..|..
Human   879 FSYNNGVVM---------TSCRELDNNRSALSAASAF--AIATAG---ANEGTPNKEKYRRMSLA 929

  Fly  2117 HSLHPSPRQSPRQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHKQRRDRD 2181
            .:..|     |.|  |...|:.:          .|.||:.:|..|.:|                 
Human   930 SAGFP-----PDQ--RNGDKEFV----------IRRAATNRVLNVLRH----------------- 960

  Fly  2182 RNPTETDATARFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLA--------------- 2231
                       ::.||..|.|..:  :..|.::.::|   |...||:.|.               
Human   961 -----------WVSKHSQDFETND--ELKCKVIGFLE---EVMHDPELLTQERKAAANIIRTLTQ 1009

  Fly  2232 EDTGDHQ-------QNDSSLSPEP---QTIVENTQQTVVVD 2262
            ||.||:|       |....:..||   .:.:|..:|..::|
Human  1010 EDPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLD 1050

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492 5/24 (21%)
RhoGEF 1456..1647 CDD:238091 42/231 (18%)
PH2_Tiam1_2 1650..1823 CDD:269957 48/301 (16%)
PH 1693..1812 CDD:278594 38/241 (16%)
RASGRF1NP_002882.3 PH 489..583 CDD:278594 6/93 (6%)
RasGEF_N 647..>695 CDD:279012 9/47 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 724..754 9/41 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 809..874 16/93 (17%)
REM <938..1007 CDD:295342 18/111 (16%)
RasGEF 1034..1270 CDD:214539 3/17 (18%)
PH_RasGRF1_2 19..154 CDD:270081 24/150 (16%)
PH 24..129 CDD:278594 19/125 (15%)
RhoGEF 244..425 CDD:214619 44/201 (22%)
PH-like 431..582 CDD:302622 17/152 (11%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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