DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and ARHGAP23

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_001186346.1	Gene:	ARHGAP23 / 57636	HGNCID:	29293	Length:	1491	Species:	Homo sapiens

Alignment Length:	1424	Identity:	251/1424 - (17%)
Similarity:	410/1424 - (28%)	Gaps:	522/1424 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 KPMPSTESPVT-----SPEMGRRRYNYYNANAAQTLGHPPHMHQH-GMAMGMGGGGGGGH----- 454
            :|.| .:.|.|     ||:.|      :.......:.:||....| .:.....||.|||.
Human    34 RPFP-WQGPRTLLLYKSPQDG------FGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRYR 91

  Fly   455 -------HIMNNNTMGRASSQSSRFSGSR-----SSHEIGRGYPPRNLYLELERERSCIEGS--P 505
                   .:.|....|.|.....| :|.|     ....||:.|  ..:...::.....:|.|  |
Human    92 LEPMDTIFVKNVKEDGPAHRAGLR-TGDRLVKVNGESVIGKTY--SQVIALIQNSDDTLELSIMP 153

  Fly   506 PSDNVM---FDNQCYATTPSSSNGNSDQDQSYGQQQSSGQ-----HPQQQQGPPQRSSRHQHHHQ 562
            ..::::   :....|.      .||....   |:.:|..:     :|::...||.|:|.......
Human   154 KDEDILQLAYSQDAYL------KGNEPYS---GEARSIPEPPPICYPRKTYAPPARASTRATMVP 209

  Fly   563 QAPNVTPT-PGSPTS------RLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQSMENLEFAES 620
            :..:..|: |.||.:      |:......||.|: :.||.....|...|..|.|:......|.|
Human   210 EPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNS-SLGMSQPRPSPGAFPHLSSEPRTPRAFPE- 272

  Fly   621 LPG------------------SNQ------RSPYPLRRPNAKSST------LPLPPHRPLSTIRD 655
             ||                  |||      ....|...|.|:|::      :..|...|.||.:|
Human   273 -PGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQD 336

  Fly   656 KERDRDRDGYYSDRNELIRERERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGS 720
            ......::|::           |.|...|||      ..:|.|..:|..|.........||.|..
Human   337 ALSQLGQEGWH-----------RARSDDYLS------RATRSAEALGPGALVSPRFERCGWASQR 384

  Fly   721 STIGSGSGHGMMTQQIPG------SG------------------------------HKRSPWDSL 749
            |   |.......|:.:||      ||                              .:.||:..|
Human   385 S---SARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGL 446

  Fly   750 PS------------------------------------------LRQ------------------ 754
            |:                                          |||
Human   447 PTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNL 511

  Fly   755 ---DSSLNDSGYKSARADSLEQRAEFI--RQDSLRSEYLSDRESRYGIVQQA------------- 801
               |.|.....  |.|.:.|.::...:  .:|||.|....|..:...|..||
Human   512 GFGDESPEPEA--SGRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAM 574

  Fly   802 -------------SIESTDSRMCYLTSSEISDDDRMSLTTAVSDE-------------DDGESVM 840
                         :...|..|......|.|....|.|...|::.|             |:|..:.
Human   575 NSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLR 639

  Fly   841 ASPYKAKAT---------------GT-----AASSFNCTGAVRKAGFLSVKK--WLLRKKHQIEL 883
            ..|.:..:.               ||     |.|..:.|..:..|.|..:::  ||..|:...:.
Human   640 RLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKK 704

  Fly   884 ARKRG-----WKGYWVCLKGTTLLFYPCDSREGRSV---------------EAAPKHLIIVDGAI 928
            .:|.|     ||..:..|:..:|..    |:|.|..               ||||   :.:...:
Human   705 GKKAGSGLRQWKRVYAALRARSLSL----SKERREPGPAAAGAAAAGAGEDEAAP---VCIGSCL 762

  Fly   929 MQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSI------------------------ 969
            :.......||.::|.|:||....|||||..:.::..|:.:|
Human   763 VDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLN 827

  Fly   970 ------HSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQ 1028
                  ||:...|.:..:|..| |..|:.|..:                        |.....::
Human   828 DYRKVSHSSGPKADSSPKGSRG-LGGLKSEFLK------------------------QSAARGLR 867

  Fly  1029 TQIL--------------QWEENLERLHCEQFRLRCYMASLQSGELPNPKSL---LTHVSRPTKN 1076
            ||.|              .|..|:                ::..:...|::.   |......|:|
Human   868 TQDLPAGSKDDSAAAPKTPWGINI----------------IKKNKKAAPRAFGVRLEECQPATEN 916

  Fly  1077 T-----------------LNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSG 1124
            .                 |...|::.|...:|.:    .||...|..|.|....:.......|..
Human   917 QRVPLIVAACCRIVEARGLESTGIYRVPGNNAVV----SSLQEQLNRGPGDINLQDERWQDLNVI 977

  Fly  1125 SSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRD 1189
            ||  .::...|..||..|    .|:.|:...  :|..:|:      ||..:..:...:     ||
Human   978 SS--LLKSFFRKLPEPLF----TDDKYNDFI--EANRIED------ARERMRTLRKLI-----RD 1023

  Fly  1190 MEDHNY----FVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWG--------FSVEAE 1242
            :..|.|    |:......|.::...::.....:.:::...|.||:.:.|..        :.:...
Human  1024 LPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVET 1088

  Fly  1243 LIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLS--- 1304
            ||::::      .:.|..||          ||:...|.:                :|.|::.
Human  1089 LIQHSD------WFFSDEED----------KGERTPVGD----------------KEPQAVPNIE 1121

  Fly  1305 -MMMRSSRTEPPDLVGIMRVTDDMIDSLVCP--------PPPTDPPVMSEEMITGLIVPAPGWN- 1359
             ::....||.||.        |...||..|.        .|..:|  .:.||:....:.|....
Human  1122 YLLPNIGRTVPPG--------DPGSDSTTCSSAKSKGSWAPKKEP--YAREMLAISFISAVNRKR 1176

  Fly  1360 ---------GTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEI 1415
                     |:|.|..|.:....|......|......      .|.:.|.:....|
Human  1177 KKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERP------QGPLPGAVAPEAP--------- 1226

  Fly  1416 ENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHL 1474
            ..|...|..|.|.::.|.|:.|..||.:.......:.|...|....:..|.||:.:.|:
Human  1227 GRLSPPAAPEERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELSHV 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	35/176 (20%)
		PH	873..974	CDD:278594	31/150 (21%)
		TIAM1_RBD	1141..1219	CDD:176413	13/81 (16%)
		PDZ_signaling	1221..1308	CDD:238492	14/98 (14%)
		RhoGEF	1456..1647	CDD:238091	5/19 (26%)
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
ARHGAP23	NP_001186346.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..34		251/1424 (18%)
		PDZ_signaling	41..151	CDD:238492	23/118 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..280		18/78 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..407		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..530		7/82 (9%)
		PH	689..808	CDD:278594	29/125 (23%)
		PH_ARHGAP21-like	690..810	CDD:269955	29/126 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	831..851		5/20 (25%)
		RhoGAP_ARHGAP21	902..1097	CDD:239860	37/223 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1155		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1175..1367		24/126 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1420..1491
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910