DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Vav3

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001365916.1 Gene:Vav3 / 57257 MGIID:1888518 Length:875 Species:Mus musculus


Alignment Length:391 Identity:92/391 - (23%)
Similarity:160/391 - (40%) Gaps:112/391 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1416 ENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEH 1480
            |:|:|..|.:..||.     .:.:.:..|...||                ||..|.:.|.::.::
Mouse   174 EDLMKAEEAQQPKSQ-----ENDIRSCCLAEIRQ----------------TEEKYTETLESIEKY 217

  Fly  1481 YLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGS 1545
            ::.|:||  ||:.||.:::|.||.::|...|..:|.:.:|:..:.|.|.::              
Mouse   218 FMAPLKR--FLTAAEFDSVFINIPDLVKVHRSLMQEIHDSIVNKDDQNLYQ-------------- 266

  Fly  1546 AFLYYVNHFKLYSSFCA------------SHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLE 1598
            .|:.|.....:|..:|:            |.:|....|...|.:.      .|.|.|    .||.
Mouse   267 VFINYKERLVIYGQYCSGVESAISNLDYISKTKEDVKLKLEECSK------RANNGK----FTLR 321

  Fly  1599 SYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHL 1663
            ..|:.|:||:|||.||||::...|.... |..:|..||..|:.:|:::||::|.:|....|    
Mouse   322 DLLVVPMQRVLKYHLLLQELVKHTHDPM-EKANLKLALDAMKDLAQYVNEVKRDNETLREI---- 381

  Fly  1664 FRQHQKSCK---QPIDL---SPGDLLYYGGVEWLNISDFLGKIK-KGLELHAM----CFVFKSAV 1717
             :|.|.|.:   ||:.|   ..||                |:|: ..|:.|..    .|:|..||
Mouse   382 -KQFQLSIENLNQPVLLFGRPQGD----------------GEIRITTLDKHTKQERHIFLFDLAV 429

  Fly  1718 VFLCKER--LRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRS 1780
            : :||.:  ..:.|:::.:......|.          |.|:.:.:..|       :.:.|||.:.
Mouse   430 I-VCKRKGDNYEMKEIIDLQQYKIANN----------PTTDKENKKWS-------YGFYLIHTQG 476

  Fly  1781 Q 1781
            |
Mouse   477 Q 477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 51/202 (25%)
PH2_Tiam1_2 1650..1823 CDD:269957 30/145 (21%)
PH 1693..1812 CDD:278594 19/96 (20%)
Vav3NP_001365916.1 CH_VAV3 2..118 CDD:409113
RhoGEF 193..369 CDD:238091 54/218 (25%)
PH_Vav 383..506 CDD:269930 27/129 (21%)
C1_VAV3 506..564 CDD:410419
SH3_VAV3_1 596..657 CDD:212914
SH2_Vav3 666..768 CDD:198270
SH3_VAV3_2 819..874 CDD:212911
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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