DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and prex1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_699627.3 Gene:prex1 / 570984 ZFINID:ZDB-GENE-030131-1428 Length:1622 Species:Danio rerio


Alignment Length:1433 Identity:270/1433 - (18%)
Similarity:488/1433 - (34%) Gaps:415/1433 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1448 RQLTDAEKLRKVVM-ELVDTERTYVKHLNNLLEHYLEPMKR----ETFLSNAEINALFGNIHEIV 1507
            |||    :||..|: |:::|||.||::|..|...:|:.:::    :..|:..::..||.||..|:
Zfish    24 RQL----RLRLCVLNEILNTERDYVRNLTFLQSAFLQRIRQTAENQQCLTQEQVKVLFSNIESIL 84

  Fly  1508 TFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVL- 1571
            ...|:||..|:.||..||..:            .::|..||.:...|.:|..:|::|.||.::| 
Zfish    85 DVHREFLSTLDASLQPEPQAH------------HSLGHVFLQFKVRFSVYGEYCSNHEKALRLLM 137

  Fly  1572 HPNEGNH--ALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCE 1634
            ..|:..|  |....|.....|:.....||.||:.|||||.||||||:::...|..:..::..:.|
Zfish   138 ELNKIPHIRAFLLHLMLLGGKKSTDVPLEGYLLSPIQRICKYPLLLRELLKRTPKKHSDYPAVEE 202

  Fly  1635 ALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDF--- 1696
            ||:.|:.|..:|||.:|..|:..|:  .:.:.|.:                 |.|..|::|.   
Zfish   203 ALQAMKAVCCNINETKRQMEKLEAL--EILQSHIE-----------------GWEGTNLTDICTE 248

  Fly  1697 ------LGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVT 1755
                  |.||..|.....:.|:|.:.:|: ||.:.|...|.....:|:......:.|.::...|.
Zfish   249 LLLQGNLLKISAGNIQERVFFLFDNLLVY-CKRKSRVSGKKSTKRTKSINGPQYVFRGRINTEVM 312

  Fly  1756 EVQVRASSAKDMDSHFL-----WELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESV 1815
            ||:.......|..|:..     |: ||     .....|.:|.....|:.:..:|..|.: .||..
Zfish   313 EVENVEDGTADYHSNNYTVTNGWK-IH-----NTAKNKWFVCMAKNAEDKQKWLDAILK-EREQR 370

  Fly  1816 RNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRH 1880
            .::.:.|:.   .:..:.....:.:..|....|...::..::::|.|        ||...|:: .
Zfish   371 ESLKLGMER---DAYVMIAEKGEKLYHMMMTKNRHLIKDRRRKLTNV--------PKCFLGNE-F 423

  Fly  1881 SAGNIDYDNLSGSQEADDLPPSV---GVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPE 1942
            .:..::...:|.::|..:|..::   |::|:.|                               :
Zfish   424 VSWLLESGEISKAEEGINLGQALLENGIIHHVS-------------------------------D 457

  Fly  1943 PHQQQQQQ--------------QQQQQQLMQQG-----HAHAHPHPHPHPREPPPPPIRQPHLHH 1988
            .||.:.:|              :.:.:.::.:|     ..|:...|....|:            |
Zfish   458 KHQFKNEQVLYRFRYDDGTYKARSEMEDIISKGVRLYCRLHSLFTPVVKDRD------------H 510

  Fly  1989 HSSDIERIDPGTK------SEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVG---------- 2037
            |....:.:.|.:|      |:|:..|::..:                   ||.||          
Zfish   511 HLKTFKSVIPASKLVEWLVSQGDSASREDAV-------------------TLGVGLCNAGFMHHV 556

  Fly  2038 ----------------------STGSQARLIQSS--------------HP---------PASYQP 2057
                                  .|.|:::.::|.              ||         ....:.
Zfish   557 LEKSEFKDESQFFRFYADEETEGTSSKSKQLRSDFKLIENILAKSLVIHPEEEDYGFEIEEKNKA 621

  Fly  2058 VLMKDLGKPSPDE-SELESESEVHA-----------AQVAASFNLSLGSSGSLFASDARDNQTQS 2110
            :::|.:.:.|..| :.|:...::::           ::|....|.|.....||....|..|:...
Zfish   622 IIVKSVSRGSYAEMAGLQPGRKIYSINEDLVFLRPFSEVETMINQSFCIRRSLRLLVATKNKEIV 686

  Fly  2111 RTQSQIHS-------------LHPSPRQSPRQSPRQSPKQDI--------------EVIEIFES- 2147
            :. ..:|.             :|...:.|...:....|.|.:              ||:|.|.. 
Zfish   687 KI-PDVHGTLPFVLSGSCPPHIHAVKKGSEAAAAGLQPGQCVLKVNGNNMNQSGYQEVLEHFSGY 750

  Fly  2148 ----EAERLAASQQVAVVHQHPSDQARESGHKQRRDRDRNPTE-TDATARFMDKHLSD------L 2201
                |.:..:..|....|::...:|....|.:...|.:...|. |.:..|.....:||      |
Zfish   751 QPVLEQQDTSCGQWAYRVYEDVEEQMSFRGCENGSDSEDGCTNGTGSVRRLEQLSISDDGPLVSL 815

  Fly  2202 EQENLTDGTCDIVAYM------ESLREKAFDPQDLAEDTGDHQQ---NDSSLSPEPQTIVENTQQ 2257
            ..:|:......:..|:      ..:.||..:|:.....|....:   .|.||      .|::.:|
Zfish   816 NVDNVHVEHGVVYEYVSPAGIKHCVLEKMVEPKGCFNLTAKILKAFVKDDSL------FVKSCRQ 874

  Fly  2258 TVVVDIESPSRPATESDSTGNTTGPSERSGDETEEEATTSSLASHIVVIDKKVDKIFKAKSPERP 2322
            .:.::.:..:.|..|.           |:..:|:.|:....::|:...:::...   ||....:.
Zfish   875 LMALNDKVVTMPQFEF-----------RNICDTKLESIDKRISSYKQFVEELQT---KAWPTFKQ 925

  Fly  2323 ASTK--VKGGRRQIYISPDRCKSQGSSPVRIIKIKSPRTSLSDQGKRLSVCSSRDNSQDRLSAGR 2385
            ||||  :.|....:   |..|.      :.::::..|:.: |..|:..|:...|.||...|.   
Zfish   926 ASTKPHILGCMDFV---PTNCH------LNLMQVSCPKNT-SSAGRAFSIRFGRKNSFFGLD--- 977

  Fly  2386 RTPSPRRSSEGGGILKHTTGPDPGILKPPSSPAKSKSPDRSCL-KKGGPSHVC---SVETLSPRV 2446
                                ||...|.|.|...       .|: ..|.||..|   ..||.:...
Zfish   978 --------------------PDQANLNPMSHSV-------HCVTSMGAPSFSCQSLDEETENGEG 1015

  Fly  2447 SPRGSMDHLSPDRGMTSSSCLRHSPRSSFDSHGESDHNLDV------------------------ 2487
            :...|..|  .:.|:  |..|:.....|.|::....:.||:                        
Zfish  1016 NSEDSRKH--EEGGL--SFLLKQEDTESQDNYICLYNRLDIAVREMKQYVAQIDVLLSSITGPTQ 1076

  Fly  2488 PHGSRKRSMSAHGSFETG--TRPRAQETYQYYPVYDNQTCSDHYVAAAPTGRYGGGTSSRSRLSK 2550
            |.||..      .|||:|  |.|..:||        :|..::|              ....|:..
Zfish  1077 PQGSEP------PSFESGPSTSPIPEET--------DQDKTEH--------------CGNKRVCF 1113

  Fly  2551 SLERSTSRDSTTTSSSYGHRAYGVSPDRNYVVFSSGPLRSQSAENTFSSQPIYDPLPRHPPQPL- 2614
            .:......||...:.|| ..:|.........|.|...:||.|:..........|.||.....|. 
Zfish  1114 KVNEDDQEDSGHDTMSY-RDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMQIPFD 1177

  Fly  2615 HQPPMHHQQQQQQQQQQQYMSY--APEMGGYTGCQHDPQGGYQLSSSAPEYTTCIDCLYQKRPSX 2677
            .|..:|...:....|.....|.  .|.|.  ..|:....  :....|.||:....|...:.|...
Zfish  1178 KQDKLHGCLEHLFNQVDSINSLLKGPVMS--KACEETKH--FHTDHSQPEFRHTDDWTVRWRYVL 1238

  Fly  2678 HKS 2680
            ||:
Zfish  1239 HKN 1241

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 62/198 (31%)
PH2_Tiam1_2 1650..1823 CDD:269957 36/186 (19%)
PH 1693..1812 CDD:278594 27/132 (20%)
prex1XP_699627.3 RhoGEF 32..216 CDD:279015 61/195 (31%)
PH_Collybistin_ASEF 221..372 CDD:269931 35/177 (20%)
PH 249..363 CDD:278594 25/120 (21%)
DEP 390..470 CDD:295306 16/119 (13%)
DEP_2_P-Rex 482..574 CDD:239887 15/122 (12%)
PDZ 600..678 CDD:214570 11/77 (14%)
PDZ_signaling 684..745 CDD:238492 7/61 (11%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.840

Return to query results.
Submit another query.