DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and psda

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_009305653.1	Gene:	psda / 570918	ZFINID:	ZDB-GENE-090313-44	Length:	1611	Species:	Danio rerio

Alignment Length:	1374	Identity:	258/1374 - (18%)
Similarity:	438/1374 - (31%)	Gaps:	457/1374 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 QQVSEDLVPVNITCIQDSP----ECIFHITAYNSQVDKIL----DVRLVQPGTRIGQASECFVYW 114
            ||:|..:        .|||    ...||:....::.:|::    :.|.:.|.
Zfish   406 QQISHSM--------SDSPRQSHRVNFHLGNSKTKAEKVVNQLSEKRSISPA------------- 449

  Fly   115 KDPMTNDTWGLNFTSPIDAKQFRECCSPSFKFSRKASSSYSLKLDPPGKGKVKAKRKPLSTPASP 179
                         |||..|:          |.:.:|:....|         ::|:|.|..||:|.
Zfish   450 -------------TSPDTAR----------KLAEEATKLSVL---------MEARRTPSPTPSST 482

  Fly   180 SRVRQE-PQCTCMSAEQYARLRTDPRVRGSSTLPRNVGSHRITDVDGQQQVGSGKVVSAVSSTSL 243
            ..||.: ||      ..::|...|...:..|..  |:.:|.....:.|..|.:|  .....||.|
Zfish   483 DTVRSDSPQ------RGHSREPQDSEAQSHSNC--NLPAHEHNRKNFQTSVKTG--YQFFQSTPL 537

  Fly   244 YDNVASGGPGTNQGADTLPRQMKGGQQDRQDVANSGVNTNTPGVIVTGVGNVGSD---------- 298
            ..|:.|..|       .:|.::     :|.||.:|. ....|.:..|.:  ||.|
Zfish   538 LSNIGSTSP-------AVPARL-----NRSDVKSSS-PIRDPQIDRTQL--VGKDSPTLHRHLPT 587

  Fly   299 -MCGQNHVGSQVG---------NDDP-----AACQMDMDLSKSEGTQAGGGLHQSVGTCTSSSKG 348
             ....||..:..|         .|.|     :..:.:.|.|.:..:|...||.:    |.:..|.
Zfish   588 QYTRDNHTPTYDGQLHDTLRGHKDSPDIIRRSFTRPNTDTSATWTSQEKHGLEE----CFTRDKK 648

  Fly   349 T-----GTRNKDFGDDMTRDAHSHDMHQHNVINNNTRRK-----TKSTEDMNVD----TSTL--K 397
            :     ..:........:.|.|......|:.|..:.|.|     |.|.....|.    .|||  |
Zfish   649 SLMEVNNQKRNSLNTPGSPDNHCGVSVPHSEIKGHNRAKKEWSGTASQSSSGVKGSLVESTLHEK 713

  Fly   398 RMLKPMPSTESPVTSPEMGRRRYNYYNANAAQTLGHPPHMHQHGMAMGMGGGGGGGHHIMNNNTM 462
            :.:....|:.:...|.:.|.......||...|.    |.:|...:|...      ...:..:::.
Zfish   714 KHISSETSSRTSQKSSDSGNTAIQSENATCLQR----PSLHSQKIARAK------WEFLFGSHSE 768

  Fly   463 GRASSQSSRFSGSRSSHEIGRGYPPRNLYL------------------------ELERE------ 497
            .:.:..||..|.|..|.|.....||.:.:|                        ::|.|
Zfish   769 DQQTKDSSTPSSSGCSSESPTPIPPLSTHLRPVTTHSRHYKSIGSSKSSCQDVQQVEVELISHHP 833

  Fly   498 -----------RSCIEGSPPSDNVMFDNQCYATTPSSSNGNSDQ---DQSYGQQQS--------- 539
                       |..::.| .:|......:||..|.......::|   |.::|..:|
Zfish   834 TVGTSNKTGIIRRTVKYS-ETDIDAVPLRCYRETDLDEVMLAEQEEVDSAFGSNRSVLGTSGTTS 897

  Fly   540 ------------SGQHPQQQQGPPQRSSRHQHHHQQAPNVTPTPGSPTSRLL---LEYEMHLRNT 589
                        .|:...|.:.....:|......::..|.||......||||   |:|:......
Zfish   898 SSPLDGVLCPHTDGEEELQDEEVASWASVRMQGDKKRQNATPEGDEVFSRLLRGPLDYQPDSHTD 962

  Fly   590 LAKGMDA-----------ESYSLHTFEALLSQ------SMENLEFAESLPGSNQRSP-----YPL 632
            |...:..           :::|.| ||:::..      |..:|:..:..|..   .|     :|.
Zfish   963 LKSPISVTSPCRVSSDCLDTFSRH-FESIMESHRAKGTSYSSLDSEDITPSG---PPIFTFDFPT 1023

  Fly   633 RRP----------------NAKSSTLPLPP------------HRPLSTIRDKERDRDRDGYY--- 666
            ..|                |..|.|.|.||            ||     .|:....:.||.:
Zfish  1024 LTPEIQSQICESAKQITELNFASLTCPEPPTVSHLIVASQDLHR-----EDRSSVCEEDGLFCTG 1083

  Fly   667 ----------SDRNELIRER--------ERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHS 713
                      ||.:...|||        :.|...........:.:|...|........|:.....
Zfish  1084 SHSEQTHRPDSDSDATKRERPSRPVSESDPEVAERLALGSTETLANGNKADLQAAKRLAKRLYTL 1148

  Fly   714 DGWRS-----------------GSSTIGSGSGHGMMTQQ----------IPGSGHKRS------- 744
            ||::.                 ....:...:..|||..|          :.|...:|.
Zfish  1149 DGFKKSDVARHLSKNNEFSHMVAEEYLSHFNFSGMMVDQALRVFLKEFALMGETQERERVLSHFS 1213

  Fly   745 -----------PWD--------SLPSLRQDSSLNDSGYKSA------RADSLEQRAEFIRQDSLR 784
                       |::        :|..|..|...::.|.:.:      ....|....:| .:|.|:
Zfish  1214 KRYLQCNPKTIPYEDSVHTLTCALMLLNTDLHGHNVGKRMSCMQFIGNLQGLNDGQDF-PKDLLK 1277

  Fly   785 SEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKAKAT 849
            :.|.|.:..:.    |.:|:..:.|..:                   .|.||....|| :..|..
Zfish  1278 ALYNSIKNEKL----QWTIDEEELRKSF-------------------SEMDGRKDSAS-HTMKRI 1318

  Fly   850 GTAASSF-----NCTGAVRKAGFLSVKKWLLRKKHQIELAR-----KRGWKGYWVCLKGTTLLFY 904
            .:..:|.     ..:..|.|.||      |:||.|.....:     |||||.::..|||..|...
Zfish  1319 SSGGNSLISVAQQSSAQVYKNGF------LVRKVHADPDGKKTPRGKRGWKTFYAILKGLILYLQ 1377

  Fly   905 PCDSREGRSV-EAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNS 968
            ..:.|..:.: :...|:.:.:..::.....::.||..:|.|.||....:|||||...::::|:..
Zfish  1378 KDEYRPDKQLSDEDLKNAVSIHHSLAMRAADYSKRPNVFYLRTADWRVFLFQAPNAEQMQSWITR 1442

  Fly   969 IHSACA--------AA------FARHRGKTGTLHLLQEEIFRLEKAIESDHKLKH---MAELQQ- 1015
            |::..|        ||      |:|.........|.|||..:       .|:.:.   .||||:
Zfish  1443 INTVAAMFSAPPFPAAIGSQKKFSRPLLPGSNTKLSQEEQLK-------SHETRFRTVSAELQEL 1500

  Fly  1016 -SVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLN 1079
             |...|::|:.:.|.:..|.||.|:   .|:.|...|...|:                    |..
Zfish  1501 RSTPQDRKTKSRDQEEYKQREEYLD---FEKTRYGTYTMLLR--------------------TKI 1542

  Fly  1080 KLGVFTVSSFHAFI--------CARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRD 1136
            ::|...:::|...:        ...||:|..: ::...:||.    .|||:||||||:.:.:|:
Zfish  1543 RMGETDLAAFEGRLFEDSGLQRTHSSPTLPQD-ISHASSTKE----TSRSSSGSSRRTKRSDSQ- 1601

  Fly  1137 EPEKTFKVA 1145
              ..:||.|
Zfish  1602 --RHSFKQA 1608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674	15/93 (16%)
		PH1_Tiam1_2	860..985	CDD:269937	37/144 (26%)
		PH	873..974	CDD:278594	28/106 (26%)
		TIAM1_RBD	1141..1219	CDD:176413	3/5 (60%)
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
psda	XP_009305653.1	Sec7	1136..1288	CDD:238100	20/152 (13%)
psda	XP_009305653.1	PH_EFA6	1332..1456	CDD:270107	33/129 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910