DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and arhgef19

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_005162265.1	Gene:	arhgef19 / 569202	ZFINID:	ZDB-GENE-090313-243	Length:	958	Species:	Danio rerio

Alignment Length:	504	Identity:	111/504 - (22%)
Similarity:	192/504 - (38%)	Gaps:	155/504 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1430 SPTGSVTSSVSTT--------ALTPSRQL----TDAEKLRKVVMELVDTERTYVKHLNNLLEHYL 1482
            ||:.|..||..:.        .:..|.||    .:..||::...|||.:|.:|::.|:..::|::
Zfish   494 SPSSSFRSSRGSAFSLWQDIPDVRSSGQLDNFSNEERKLQEAKFELVTSEASYIRSLSIAVDHFM 558

  Fly  1483 EPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKF-------EHCGQFRNVL 1540
            ...:....|...|...||..:.::.....:|||:||..  ||.|..:|       :||...|.|
Zfish   559 MSSELCECLGTQERQWLFSKLPDVKEVSERFLQDLERR--LEGDILRFDVCDIVLDHCPALRRV- 620

  Fly  1541 FAIGSAFLYYVNH----FKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYL 1601
                  :|.||.:    .:.|......:::...:|...|     ::.:..|.|       |.|:|
Zfish   621 ------YLPYVTNQAYQEQTYQRLLQENARFPGILARLE-----EDPICQRLP-------LTSFL 667

  Fly  1602 IKPIQRILKYPLLLQQ-MRNLTDTRADEH------------VHLC-EALKGMEKVAEHINEMQRI 1652
            |.|.|||.:..:|::. ::..|....||.            :..| .:::.|:::.|.|:..::|
Zfish   668 ILPFQRITRLKMLVENILKRTTPGSRDEDTATKALNELKKIIKECNSSVQSMKRMEELIHLNKKI 732

  Fly  1653 HEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIK---KGLELHAM--C-- 1710
            |.| |.||. |..|.:...|.      |:||   .|:..|:|....|.|   :.:.||..  |
Zfish   733 HFE-GKIFP-LISQSRWLVKH------GELL---EVDTQNLSISGSKFKLTTRPVYLHLFNDCLL 786

  Fly  1711 ----------FVFKSAVVFLCKERLRQK---KKLMGVSS---KNATNEVEIIRYQVLI------- 1752
                      .||..|.:    |.|:.|   :||.|:|.   .....|.:.:::|:|:
Zfish   787 LSRRKESWKFMVFVHAKI----EDLKVKDLSQKLQGISGFIFYLQLCEGQQLKHQILLKSPTESS 847

  Fly  1753 ------------PVTEVQ-------------VRASSAKDMDSHFL---------------W-ELI 1776
                        |.|.::             :|:..|::.|...|               | |.|
Zfish   848 KQRWITAMFPSDPTTAIEQTNENDDLSQVQCIRSYQAQEHDELTLEKADILQAVTITSDGWVEGI 912

  Fly  1777 HLRSQLQRRSEKVYV--LSNSTADFRNAFLKTIRQIIRESVRNMSIPMK 1823
            .|....:....|.||  :::.:|..||         :||::|...:..|
Zfish   913 RLSDGERGWFPKTYVEEITSRSARLRN---------LRENIRIKCVSQK 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	48/215 (22%)
		PH2_Tiam1_2	1650..1823	CDD:269957	52/245 (21%)
		PH	1693..1812	CDD:278594	35/191 (18%)
arhgef19	XP_005162265.1	RhoGEF	537..713	CDD:279015	44/196 (22%)
		PH_ephexin	735..862	CDD:269929	32/141 (23%)
		PH	748..855	CDD:278594	25/119 (21%)
		SH3_ARHGEF5_19	875..929	CDD:212873	11/53 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910