DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and spata13

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_005162798.1 Gene:spata13 / 568426 ZFINID:ZDB-GENE-091116-25 Length:1251 Species:Danio rerio


Alignment Length:1432 Identity:281/1432 - (19%)
Similarity:488/1432 - (34%) Gaps:472/1432 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   668 DRNELIRERERERDRGYLSDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSGHGMM 732
            :.|.|.|.:...:....::|..:....||........|:::         .|:|..|.     .:
Zfish    51 EENRLNRLKSHAQSVPVIADGQAKLYPSRTVRLFPTQAKSE---------DGASQRGP-----PV 101

  Fly   733 TQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDRESRYGI 797
            |.|         .|..|...|...|     :|..|...|:.              :.:|.:..|.
Zfish   102 TPQ---------AWSGLAGFRVMGS-----FKKLRTSVLQG--------------IQNRSNAMGA 138

  Fly   798 VQQASIEST--DSRMCYLTSSEIS------------DDDRMSLTTAVSDEDDGESVMASPYKAKA 848
            .|:.::.|.  ||....:|..|||            ...|...|::||||||.|.|         
Zfish   139 SQERNLSSVIEDSSSFLVTKREISISQTHETEKVLNGTSRTRKTSSVSDEDDCEEV--------- 194

  Fly   849 TGTAASSFNCTGAVRK---AGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSRE 910
            .|...:| :.:.::||   ||.:|:          :::..|:.                      
Zfish   195 CGFQRNS-HFSQSIRKAYGAGRISM----------LDMVNKQS---------------------- 226

  Fly   911 GRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSA--C 973
                                             ||||..|.              ||::.|.  |
Zfish   227 ---------------------------------LSTAEPDP--------------VNTVESTEPC 244

  Fly   974 AAAFARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQI-QTQILQWEEN 1037
                 .::...|.:.:|:    ||.|:.::.|..|  ...::.|.|.:....:. .|.:||...:
Zfish   245 -----NNQDTQGNVKVLK----RLSKSADNLHVFK--THFRRKVATAEPQNPECSSTVMLQRTSS 298

  Fly  1038 LERLHCEQFRLRCYMASLQS-GELPNPKSLLTHVSRPTKNTLN---KLGVFTVSSFHAFICARSP 1098
            ...:..::..|..:.:.::: |.|......||.::...||..:   ::.|..:|..|.....|:|
Zfish   299 SSSVDLQEHVLGSHQSPMRTRGHLQKLVGSLTDLTVKRKNIASPSPRVPVSPLSQLHDDYSRRTP 363

  Fly  1099 SLLNNLLAGRGATKRRP-PMLSRSNSGSSRRSMQM----------------NSRDEPEKTFKVAM 1146
            .:..   :||   :||| |:.:::...|:.:::.:                :|.:.|.||     
Zfish   364 CVPT---SGR---QRRPSPVPTKTQQDSTCQTIPILHPAPSCPAVFISDLDDSLEPPSKT----- 417

  Fly  1147 PDNAYSTVYLRDAMSVEEFLA--SAC-ARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYL 1208
              .|..:.|::.|:|..|...  ||| ..:...|||                  .|:|.|.::|.
Zfish   418 --TALISDYVQMAVSSSELHIGDSACPPEKYCEPME------------------CHQNGLNDHYS 462

  Fly  1209 H-NHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAE---------RQDEL---------- 1253
            . ..:....|:|  ..|......|:.:|....|.:.:|.:.         :.||.          
Zfish   463 QIPQQCSSPCLK--PTVNGNDVNLQCLWTEERETDDLEASSDNRITRAFLKSDEASTPAASPITN 525

  Fly  1254 -CCYVSRVEDKSVAMHNGIIKGDEIMVI---------------NGAIVS----------DLDMM- 1291
             ||..|.:...:.......:......|:               .|.:.|          :|:.| 
Zfish   526 SCCSESPLGTPTTPNSPAFVSASPTSVVPRKRAGRSKPRPVSDYGQLASSKFCILEEDRELENMD 590

  Fly  1292 ------------YLESVLQEEQSLSMMMRSSRTEPPDLVGIMRV--------TDD--MIDSLVC- 1333
                        |:||...|...:.....|.:..|..::|.:.:        .||  .:.|.|| 
Zfish   591 YTSQKDYISNGSYIESSRPENGHVCTQKESRKRRPISVIGGVDLYSSQPAEQKDDTESLPSPVCR 655

  Fly  1334 PPPPTD--PP-----------VMSEEMITGL----------IVPAPGWNGTSKDLYSPE----AE 1371
            ||.|:.  ||           |.|:....||          ::.....:...:|..|.|    .|
Zfish   656 PPVPSHRVPPYRAVSARLRPCVFSQSTPIGLDRMGRRKGRRVLSDGSSDPMLEDSVSEEDGSFEE 720

  Fly  1372 SSPATSFVDPAAMAAQLAVGGVGGVVV------GGLGVAKPTSRTSSFEIENLLKTAEQE----- 1425
            .:..|.::.|......|......|..|      ..:.:.:......:.|:..:|...||:     
Zfish   721 LTEGTPYLQPEVDLFTLNQHIESGRAVYAEALWDHVTMEEQELAFKAGEVIRVLDVQEQDWWWGM 785

  Fly  1426 -----------------TRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRK-----VVMELVDTER 1468
                             .::.|.:.||.|:..|....||.......:.||     ||.|::||||
Zfish   786 VGDREAWFPSSFVRVRVNQEDSSSESVESTPDTEEPIPSDSHKQNPEHRKQMRANVVKEIMDTER 850

  Fly  1469 TYVKHLNNLLEHYLEPMKRET-FLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLE-PDFNKFE 1531
            .|:|||.::.|.|:...::.. ..::.::..:|.||.:|..|||:||::||...:.| |..::  
Zfish   851 VYIKHLKDICEGYIRQCRKHPGMFTDTQLKTIFSNIEDIYRFQRKFLKDLERKYNPENPHLSE-- 913

  Fly  1532 HCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASH----SKAQKVLHPNEGNHALQEFLAARNPKQQ 1592
                       |||.||.....|.:||.:|.:|    ::.|:::..:...|.   |.|.|..:|.
Zfish   914 -----------IGSCFLQQEEGFSIYSEYCNTHPVACAELQRLMKQSRYKHF---FEACRLLQQM 964

  Fly  1593 HSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYG 1657
            ...::..:|:.|:|:|.||||.|.::...|.....:...:|.|.|.|:.||..|||.:|..|...
Zfish   965 IDISIAGFLLTPVQKICKYPLQLGELLKYTPKEHSDFAGVCAAHKAMKNVASLINERKRRLESID 1029

  Fly  1658 AIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFL---GK----IKKGLELHAMCFVFKS 1715
            .|      .|.:..          :|::.|.:.|..|..|   |:    ::.|.......|:|..
Zfish  1030 TI------AHWQVA----------ILHWAGEDVLARSSELIHSGELTRIVRPGKTQQRSYFLFDH 1078

  Fly  1716 AVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRS 1780
            .:||..|:.||  :.|:....:..|:.:|                   ..|:......||..|::
Zfish  1079 QLVFCKKDVLR--RDLLHYRGRMDTDLLE-------------------PSDLPDGRHTELGLLKN 1122

  Fly  1781 Q-LQRRSEKVYVL-------SNSTADFRNAFLKTIRQI---------IRESVRNMSI-------- 1820
            . |.|.:|.:.||       |.....:..||.:..:::         |.|:.|..::        
Zfish  1123 AFLLRHAENLNVLCVLCCKKSQDKQRWLQAFARERKRVQEDQEMGMEITEAQRKQAVHNARKSKH 1187

  Fly  1821 -PMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLER------------PKQQITIVHGSHTLGKPK 1872
             .|||.     :.|||.:        |.:.|.|..            |:||:      .||.:||
Zfish  1188 GKMKNM-----NYSGHPA--------PPHHQPLHPLHQRHVTVPTSVPQQQV------FTLAEPK 1233

  Fly  1873 KK 1874
            ||
Zfish  1234 KK 1235

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 15/129 (12%)
PH 873..974 CDD:278594 9/102 (9%)
TIAM1_RBD 1141..1219 CDD:176413 17/81 (21%)
PDZ_signaling 1221..1308 CDD:238492 19/144 (13%)
RhoGEF 1456..1647 CDD:238091 60/201 (30%)
PH2_Tiam1_2 1650..1823 CDD:269957 36/205 (18%)
PH 1693..1812 CDD:278594 26/142 (18%)
spata13XP_005162798.1 SH3 747..800 CDD:327375 5/52 (10%)
RhoGEF 841..1020 CDD:214619 59/194 (30%)
PH_Collybistin_ASEF 1025..1163 CDD:269931 32/174 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.840

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