DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and farp2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_009300696.1	Gene:	farp2 / 567490	ZFINID:	ZDB-GENE-030131-2993	Length:	1051	Species:	Danio rerio

Alignment Length:	941	Identity:	187/941 - (19%)
Similarity:	328/941 - (34%)	Gaps:	263/941 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   989 LLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQF------- 1046
            ||..::||....||||:.......||.:.|....:: .|..|:.:....|.||..:.|
Zfish    75 LLLSDVFRRINLIESDYFGLEFQNLQMNWVWLDPSK-LIVKQVRRPMNTLFRLSVKFFPPDPGQL 138

  Fly  1047 --RLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSS---FHAFICARSPSLLNNLLA 1106
              ....|:.|||.     .:.||......|:||...|....|.|   .:..:..|....:|.||.
Zfish   139 QEEFTRYLFSLQI-----KRDLLDGRLSCTENTAALLASHLVQSEIGDYDDLADREFLKMNKLLP 198

  Fly  1107 GRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEF------ 1165
            .:...:.:...|.|.::|.:          ..|..|:|           |..|..:|.|
Zfish   199 CQEHVQEKIMELHRRHTGQT----------PAESDFQV-----------LEIARKLEMFGVRFHP 242

  Fly  1166 --------LASACARRNLNPMEHFVRV-------------KKRRDM-----EDHNYFVPHRNDL- 1203
                    :..|.|...|...:...::             |::|.:     |.|.   ||::.|
Zfish   243 AADREGTKINLAVAHMGLQVFQGHTKINTFNWSKIRKLSFKRKRFLIKLHPEVHG---PHQDTLE 304

  Fly  1204 ------------IENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCY 1256
                        .:|.:.:|.|    .::|.|.:.:...:    .||..:....:...|.:|
Zfish   305 FLMGSRDQCKIFWKNCVEHHSF----FRLLDQPQPKSKAI----FFSRGSSFRYSGRTQKQL--- 358

  Fly  1257 VSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYL------------ESVLQEEQSLSMMMRS 1309
            |..|.|..:.......:..:|.:...::.||:....|            .|:....|||.....|
Zfish   359 VEYVRDSGLRRTPYQRRNSKIRMSTRSLASDVPKQNLSFNDSLRTHIPPSSITASFQSLHAPSVS 423

  Fly  1310 SRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMIT-----GLIVPAPGWNGTSKDLYSPE 1369
            .|.|.|:  .::.:.......|..|.|....|:.:....|     .:.:.:|        ..||.
Zfish   424 MRAETPN--QLLHLHQTQHQPLRAPSPMKQDPIKTNSQSTYAFPDSIAIDSP--------QLSPF 478

  Fly  1370 AESSPATSFVDPAAMAAQLAVGG-----VGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKS 1429
            .:..|..  :.|:...:.|::.|     :...::..:|.|:             |...|:..||.
Zfish   479 NDKGPLC--LSPSFQMSTLSLPGQAPSPLQSPILNEVGTAR-------------LDEDEEGRRKR 528

  Fly  1430 SPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNA 1494
            .||                     :|...:..|::.|||||:|.|..:...:...:.:|..:...
Zfish   529 YPT---------------------DKAYFIAKEILTTERTYLKDLEVITVWFRSAVIKENAMPEG 572

  Fly  1495 EINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSS 1559
            .:..||.||..|..|.|.||:.:::.|.|....:.....|.::.    ||...|..:...|.::.
Zfish   573 LMTLLFSNIDPIYEFHRGFLKEIDQRLALWEGRSNAHVKGDYQR----IGDVMLRNMCSLKEFTG 633

  Fly  1560 FCASH----------SKAQKVLHPNEGNHALQE--FLAARNPKQQHSSTLESYLIKPIQRILKYP 1612
            :...|          :|..|.|........||:  :|           .|.::|:|||||::.|.
Zfish   634 YLQKHDEVLTELEKATKRVKKLETVYKEFELQKVCYL-----------PLNTFLLKPIQRLMHYK 687

  Fly  1613 LLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFR--QHQKSCKQPI 1675
            |:|::   |....:.:|....:..:.:::|||...::|          ..|.|  ..||..:...
Zfish   688 LILER---LCKHYSPQHRDYDDCKEALKEVAEIATQLQ----------SSLIRLENFQKLTELQR 739

  Fly  1676 DLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNAT 1740
            ||...:.|...|.|::.........||||: ..|.|:|...:::..|          ||:   ||
Zfish   740 DLIGIENLTAPGREFIREGCLYKLTKKGLQ-QRMFFLFSDMLLYTSK----------GVT---AT 790

  Fly  1741 NEVEI-----IRYQVLI----PVTE-------------------VQVRASSAKDMDSHFLW-ELI 1776
            |:.::     :...:||    ||.|                   :.|.|||..:|:.   | |.:
Zfish   791 NQFKVHGQLPLHGMILIVLDAPVEESENEWSVPHCFTIYSAQRTIVVAASSKVEMNK---WIEDL 852

  Fly  1777 HLRSQLQRR-SEKVYVL--------SNSTAD 1798
            ::..::.:: .||..||        ||.::|
Zfish   853 NMAIEMSKKCQEKSDVLLDPSLCDRSNRSSD 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413	19/122 (16%)
		PDZ_signaling	1221..1308	CDD:238492	17/98 (17%)
		RhoGEF	1456..1647	CDD:238091	47/202 (23%)
		PH2_Tiam1_2	1650..1823	CDD:269957	42/189 (22%)
		PH	1693..1812	CDD:278594	32/144 (22%)
farp2	XP_009300696.1	B41	53..241	CDD:214604	43/192 (22%)
		FERM_N	55..118	CDD:286467	13/43 (30%)
		FERM_M	138..241	CDD:278785	26/128 (20%)
		FERM_C_FARP1-like	228..348	CDD:270014	20/130 (15%)
		FA	341..382	CDD:285894	8/43 (19%)
		RhoGEF	537..720	CDD:279015	47/200 (24%)
		PH1_FARP1-like	747..861	CDD:269928	28/130 (22%)
		PH	755..857	CDD:278594	25/118 (21%)
		PH2_FARP1-like	933..1030	CDD:270055
		PH	938..1031	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910