DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and arhgef16

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_005167338.1	Gene:	arhgef16 / 567180	ZFINID:	ZDB-GENE-081104-446	Length:	662	Species:	Danio rerio

Alignment Length:	467	Identity:	96/467 - (20%)
Similarity:	180/467 - (38%)	Gaps:	94/467 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1401 LGVAKPTSRTSSFEIE--------------NLLKTAEQETRKSSPTGS----VTSSVSTTALTPS 1447
            ||..:......||:.|              :.|.|.|:|.....|.|.    |..:.....:|.|
Zfish   167 LGRIRNRKHAGSFKDEPRFYQEIKERGLNVSSLSTEEEELSPVGPPGEDQGIVVKNYRAAYITWS 231

  Fly  1448 R--QLTD----------AEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALF 1500
            :  |:.|          ..|.::|:.|::.:|.:|...|:.|:.|:.:.:.....::..|.:.||
Zfish   232 QLPQVKDLGILDFITPEERKRQEVIFEIITSEYSYQHSLSILVRHFKDSVDLRKTMTATEHHHLF 296

  Fly  1501 GNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHS 1565
            .||..|....::|.::|::.....|...:....            ...|...||:.|..:|::.:
Zfish   297 SNISVIQDVSKRFFEDLDKRHQANPVIERISDI------------VATYATKHFEPYIVYCSNET 349

  Fly  1566 KAQKVLHP-NEGNHALQEFLAARNPKQQHSS------TLESYLIKPIQRILKYPLLLQQMRNLTD 1623
            ..|:.|.. ...|.|.:|.|     ||..:|      .:.|:||.|:||:.:.|||:..:...|.
Zfish   350 FQQRTLQKLLSSNSAFRETL-----KQIETSEDCGGLPMLSFLILPMQRVTRLPLLMDTICEKTT 409

  Fly  1624 TRADEHVHLCEALKGMEKVAEHINE----MQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLY 1684
            ....|:...|.|.|.:.|:.:..|:    |:|..:.|     .:.:|.:....:|..|
Zfish   410 KETAEYYKACWAFKAISKLVKSCNDGARRMERTEQMY-----TIQKQMEFGKIKPFPL------- 462

  Fly  1685 YGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQ 1749
            .....||..|..|......|.:....|.|||..:||..:.|        :.:|..:.|..::...
Zfish   463 VSSSRWLKKSGELAVYTDDLSIFRKAFSFKSYYLFLFNDVL--------IVTKKKSEESYVVLDY 519

  Fly  1750 VLIPVTEVQVRASSAKDMDSHFLWELIHLRSQL----QRRSEKVYVLSNSTADFRNAFLKTIRQI 1810
            ..:...||:...|.:|          ::|:..:    ..|||::.:::.:.. .|..::..:|.:
Zfish   520 ATVEKVEVEEEMSDSK----------LNLKLMMNPNSDGRSEQLVLVAENKL-VRAQWVTALRDV 573

  Fly  1811 IR-ESVRNMSIP 1821
            .: .|:.|..:|
Zfish   574 KQTSSIDNDDLP 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	45/197 (23%)
		PH2_Tiam1_2	1650..1823	CDD:269957	32/177 (18%)
		PH	1693..1812	CDD:278594	22/122 (18%)
arhgef16	XP_005167338.1	RhoGEF	255..434	CDD:279015	45/195 (23%)
		PH_ephexin	456..577	CDD:269929	26/146 (18%)
		PH	469..574	CDD:278594	23/123 (19%)
		SH3_ARHGEF16_26	586..639	CDD:212871	96/467 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910