DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and AgaP_AGAP010472

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_001689404.1	Gene:	AgaP_AGAP010472 / 5668042	VectorBaseID:	AGAP010472	Length:	248	Species:	Anopheles gambiae

Alignment Length:	349	Identity:	68/349 - (19%)
Similarity:	106/349 - (30%)	Gaps:	162/349 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly  2369 SVCSSRDNSQDRLSAGRRTP----SPRRSSEGGGILKHTTGPDPGILKPPSSPAKSKSPDRSCLK 2429
            ::.::|..|.|..|:...|.    |...:...|..|.:||          :||..|.||
Mosquito    17 TITTARTTSADISSSSSATAIATVSTNTTCLTGYQLSNTT----------NSPTSSSSP------ 65

  Fly  2430 KGGPSHVCSVETLSPRVSPRGSMDHLSPDRGMTSSSCLRHSPRSSFDSHGESDHNLDVPHGSRKR 2494
                          |..||        .||.:||:. :..:|:|             |..||...
Mosquito    66 --------------PATSP--------TDRSITSAP-ITGNPQS-------------VTSGSSSS 94

  Fly  2495 SMSAHGSFETGTRPRAQETYQYYPVYDNQTCSDHYVAAAPTGRYGGGTSSRSRLSKS---LERST 2556
            :::|                               |.::.|.|      :||.|.||   |:::|
Mosquito    95 AITA-------------------------------VVSSGTKR------TRSLLLKSTSPLQQTT 122

  Fly  2557 -SRDSTTTSSSYG----------HRAYGVSPDRNYVVFSSGPLRSQSAENTFSSQPIYDPLPR-- 2608
             |..|.|.||..|          |....|||      .::||        |||:.|..||:..
Mosquito   123 HSSPSHTVSSPQGPPVPPRLSHIHAIGSVSP------ANTGP--------TFSNHPSIDPISTTT 173

  Fly  2609 ---------------------HPPQPLHQPPMHHQQQQQQQQQQQYMSYAPEMGGYTGCQHDPQG 2652
                                 .||.|   .|:....:.::.....:.|..|.:
Mosquito   174 SSNASSEAIVMSSIVTGTCYVTPPTP---APLITSDKHRELPSMTFGSVTPTV------------ 223

  Fly  2653 GYQLSSSAPEYTTCIDCLYQKRPS 2676
               :|::.|:.||.....:.|.|:
Mosquito   224 ---VSNTLPDSTTLTASGHNKTPT 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
AgaP_AGAP010472	XP_001689404.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910