DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and PSD

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_001257894.1	Gene:	PSD / 5662	HGNCID:	9507	Length:	1024	Species:	Homo sapiens

Alignment Length:	1175	Identity:	260/1175 - (22%)
Similarity:	375/1175 - (31%)	Gaps:	413/1175 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 PPGK--GKVKAKRKPLSTPAS---------PSRVRQEPQCTCMSAEQYARLRTDPRVRGSSTLPR 213
            |.|:  |:|.|...||..|.|         ||....:|.....|:....|......||..:.||.
Human    55 PRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPA 119

  Fly   214 NVGSHRITDVDGQQQVGSGKVVSAVSSTSLYDNVASGGPGTNQ-------GADTLPRQMKGGQQD 271
            ..|..|..|:.|         ||....|...      |||:|:       .:|.||  .:||
Human   120 PGGLSRSWDLGG---------VSPPRPTPAL------GPGSNRKLRLEASTSDPLP--ARGG--- 164

  Fly   272 RQDVANSGVNTNTPGVIVTGVGNVGSDMCGQNHVGSQVGNDDPAACQMDMDLSKSEGTQAGGGLH 336
                      :..||              .:|.|     :..||..|:..|...|......||..
Human   165 ----------SALPG--------------SRNLV-----HGPPAPPQVGADGLYSSLPNGLGGPP 200

  Fly   337 QSVGTCTSSSKGTGTRNKDFGDDMT--RDAHSHDMHQHNVINNNTRRKTKSTEDMNVDTSTLKRM 399
            :.:.|.......||..|:  ||..:  |:..||           .:|..::..:....:
Human   201 ERLATLFGGPADTGFLNQ--GDTWSSPREVSSH-----------AQRIARAKWEFFYGS------ 246

  Fly   400 LKPMPSTESPVTSPEMGRRRYNYYNANAAQTLGHPPHMHQHGMAMGMGGGGGGGHHIMNNNTMGR 464
            |.|..|...|   ||              |....||         |:|...|.|      ..:||
Human   247 LDPPSSGAKP---PE--------------QAPPSPP---------GVGSRQGSG------VAVGR 279

  Fly   465 ASSQSSRFSGSRSSHEIGRGYPPRNLYLE-------LERER--SCIEGSPPSDNVMFDNQCYATT 520
            |:..|          |......|...|.|       .|||.  |.||..|.|:..  ....|...
Human   280 AAKYS----------ETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGP--PGTAYPPA 332

  Fly   521 P------------SSSNGNSDQDQSYGQQQ--------SSGQHPQQQQGPPQRSSRHQHHHQQAP 565
            |            .|.|.:.|.|::.|::.        |.|..|..:.  |.:|.     ....|
Human   333 PRPGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRM--PLKSP-----VPFLP 390

  Fly   566 NVTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESY-SLHTFEALLSQSMENLEFAESLPGSNQRSP 629
            ..:|:...|.| ....:|..|.:..|||   .|| ||.:.|||.|            ||..| ||
Human   391 GTSPSADGPDS-FSCVFEAILESHRAKG---TSYTSLASLEALAS------------PGPTQ-SP 438

  Fly   630 Y---------PLRRPNAKSSTLPLPPHRPLSTIRDKERDRDRDGYYSDRNELIRERERERDRGYL 685
            :         |..||:..:.. ||.|..|     |.......||.::.|.|   |.|.|. |..|
Human   439 FFTFELPPQPPAPRPDPPAPA-PLAPLEP-----DSGTSSAADGPWTQRGE---EEEAEA-RAKL 493

  Fly   686 SDHNSSFSNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLP 750
            :....  ..|.|.|             .|....|::.:||   ...::|.:..|.   |..||..
Human   494 APGRE--PPSPCHS-------------EDSLGLGAAPLGS---EPPLSQLVSDSD---SELDSTE 537

  Fly   751 SLRQDSSLNDSGYKSARADSLEQRAE-FIRQDSLR-------------------SEYLS------ 789
            .|...|:...|..:.|..::.::.|: ..|.|..|                   .|||.
Human   538 RLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTG 602

  Fly   790 ---DRESRYGIVQQASIESTDSRMCYLT-----------SSEISDDDRMSLTTAVS--------- 831
               |:..|..:.:.|.:..|..|...|.           .:..|:|...:||.|:.
Human   603 MTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGH 667

  Fly   832 ---------------------------------------------DEDD---GESVMASPYK--- 845
                                                         ||::   ..|.:|.|..
Human   668 NIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADPNPKVI 732

  Fly   846 ---AKATGTAASSF-NCT----GAVRKAGFLSVKKWLLRKKHQIELAR-----KRGWKGYWVCLK 897
               :..:|:.:|.| :.|    .||.|.|.      |:||.|.....|     |||||.:...||
Human   733 KRISGGSGSGSSPFLDLTPEPGAAVYKHGA------LVRKVHADPDCRKTPRGKRGWKSFHGILK 791

  Fly   898 GTTLLFYPCDSREGRSV-EAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVE 961
            |..|.....:.:.|::: |...|:.|.:..|:.....::.||.::|.|.||....:|||||...:
Human   792 GMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQ 856

  Fly   962 LENWVNSIHSACA--------AA------FARHRGKTGTLHLLQEEIFRLEKAIESDHKLKHMAE 1012
            :::|:..|:...|        ||      |:|....:....|.|||..|..:|     |||.||
Human   857 MQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEA-----KLKAMA- 915

  Fly  1013 LQQSVVTDQETRHQIQTQI------LQWEENLER---LHCEQFRLRCYMASLQ------SGELPN 1062
                    .|.|.....|:      .:.||..::   |..|:.|...|.|.|:      |.||..
Human   916 --------SELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLKAGSEELDA 972

  Fly  1063 PKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSL----LNNLLAGRGATKRRPPMLSRSNS 1123
            .::.|.... .|::.|        ...|:     ||||    .:...|.|.:::.||      .:
Human   973 VEAALAQAG-STEDGL--------PPSHS-----SPSLQPKPSSQPRAQRHSSEPRP------GA 1017

  Fly  1124 GSSRR 1128
            ||.||
Human  1018 GSGRR 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	41/144 (28%)
		PH	873..974	CDD:278594	32/106 (30%)
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
PSD	NP_001257894.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..98		12/42 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..230		36/167 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..402		45/213 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..536		34/149 (23%)
		Sec7	542..708	CDD:238100	21/165 (13%)
		PH_EFA6	753..877	CDD:270107	37/129 (29%)
		PH	757..865	CDD:278594	34/113 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	976..1024		16/67 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910