DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and arhgef11

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001027010.1 Gene:arhgef11 / 565268 ZFINID:ZDB-GENE-070604-1 Length:1417 Species:Danio rerio


Alignment Length:1798 Identity:323/1798 - (17%)
Similarity:576/1798 - (32%) Gaps:670/1798 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   741 HKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDRESRYGIVQQASIES 805
            |..|..|.|.||    :|.||..:|:.....|...:           ||...:..|:||:..:..
Zfish     5 HPTSTLDRLSSL----TLGDSERRSSPGQQRETLPD-----------LSSDNTGTGLVQRCVVVQ 54

  Fly   806 TDS-----RMCYLTSSEISDDDRMSLTTAVSDEDDGESVMASPYKA----KATGTAASSFNCTGA 861
            .|:     .:|         .:|:.|...|  ...|.:|.|...:.    |..|:..||.:    
Zfish    55 RDNLGFGFTVC---------GERIKLVQNV--RPGGAAVKAGVQEGDRIIKVNGSMVSSMS---- 104

  Fly   862 VRKAGFLSVKKWLLRKKHQ--IELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIV 924
                             ||  :::.:    .|.:|.|   ||...|      .||.:.|      
Zfish   105 -----------------HQEVVKMIK----SGTYVAL---TLQGPP------PSVASTP------ 133

  Fly   925 DGAIMQPIPEHPKRDYIFCLSTAFGDA-YLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLH 988
                :||:|.    |.:....||.|:| .|.|.|                         .||:..
Zfish   134 ----LQPLPS----DLLSNHRTAPGEAPPLPQTP-------------------------PTGSST 165

  Fly   989 LLQEEIFRL--EKAIESDHKLKHMAELQQSVVTDQET------RHQIQTQILQWEENLERL--HC 1043
            ..|    |:  .|.::.....||..|:.:.::..:|.      ..|.:...:..||.:||.  ..
Zfish   166 PTQ----RITGPKPLQDPEVQKHATEILRKMLEQEEAELQNLLEEQSRNPSVSLEERIERAKRRA 226

  Fly  1044 EQFRLRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGR 1108
            .|.|::                    :.:....|                  ||.::.|.|.||.
Zfish   227 SQVRVK--------------------IQQDVDGT------------------RSDAVANYLTAGE 253

  Fly  1109 G---------------------ATKRRPPMLSRSNSG---SSRRSMQ--------------MNSR 1135
            |                     ::..|.|::.|..|.   |....||              :|..
Zfish   254 GRLSIDSSEGDVEVCESPFSSPSSFLRNPLIHRQTSDTHTSDSGKMQIIGPEEEEEDDGYTINEM 318

  Fly  1136 DEPEKTFKVAMPDNAYSTVYLRDA-------------MSVEEFLASACA-RRNLNPM--EHF--- 1181
            |.|.:..::.....|:.||::|..             :|||.:|.|:.. .|:|.|.  .||   
Zfish   319 DGPFQDIELLKSRPAHMTVFMRYVFGQLLDPNPLLFYLSVEAYLGSSPKDARSLAPQICSHFLDH 383

  Fly  1182 ---VRVKKRRD-MEDHNYFVPHRNDLIENYLHNHEFV-----EVCMKIL--YQVELQRTTLEQMW 1235
               :::|.|.: :.|           |||.||..|.:     |:..::|  .|.:||....:|..
Zfish   384 DAPLKIKVREEFLTD-----------IENRLHAQEDIRGPLSELQQQVLPDIQDQLQDYRNKQTM 437

  Fly  1236 GF----------SVEAELIENAERQDELCCYVSRV-----EDKSVAM---------HNGIIKGDE 1276
            |.          .::.:.::..:..|:....:..:     ||:|..:         |:| ||..:
Zfish   438 GLGSLFGESDLQQLDGDPVKEKQVVDKQIVALWEILSKHEEDRSSPLASAVHLYLRHSG-IKLRD 501

  Fly  1277 IMVINGAIVSDLDMMY--------LESVLQE----------------------EQSLSMMMRSSR 1311
            ..|..| ::|:.:...        |.|..:|                      :.:..:.:..:.
Zfish   502 SKVFPG-LMSEKEKWLPFFPKAKKLSSAKRERDGEDKKRNPILKYIGKPRSTSQSTFHVPLSPTE 565

  Fly  1312 TEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPAT 1376
            ..|..:..|::..:...|||       :...:..:.::|              .:..::..||..
Zfish   566 VRPGSVRNIIQQFESNSDSL-------EDGELEGQRLSG--------------SFGEDSMESPTI 609

  Fly  1377 SFVDPAAMAAQLAVGGVGGVVVGGLGVA-KPTSRTSSFEIENL-------LKTAEQETRKSSPTG 1433
            |.  ..|.:..|...|.|....||.|.. .|.|| |..::|:.       |:........|:.:.
Zfish   610 SV--RLARSESLKAQGEGRRRGGGTGAEFVPRSR-SDVDMEDCEEREGPGLRPLHHSASSSASSS 671

  Fly  1434 SVTSSVS-TTALTPSRQ----------LTDAEKL-----------------------------RK 1458
            |..|..: |...||..|          |.||..|                             :.
Zfish   672 SARSLENPTPPYTPRSQRRIVEVPVSLLPDAPALDEDVIDSHNWQDTVEPHILASLTSREIDRQA 736

  Fly  1459 VVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLE---ES 1520
            |:.||..||.::::.|..|.:.:.:  |.::.||..|::.:|.|:.::........::::   ||
Zfish   737 VIYELFTTEVSHLRTLRVLDQVFYQ--KMQSVLSPEELSCIFLNLRQVYELHASLCESMKKCRES 799

  Fly  1521 LDLEPDFNKFEHCGQFRNVLFA-----IGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGN--- 1577
            :.::          ...:::.|     .|..|...|:|      .|:..|.|.:::...:..   
Zfish   800 VIVQ----------GIGDIMLARFEGEAGDQFEEQVSH------LCSQQSPALELIKNKQRKDPR 848

  Fly  1578 --HALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGME 1640
              |.:||..|:.:.::..   |:..|:..:||:.||||||..:...|:|.:.:...|..|.....
Zfish   849 FAHLIQECEASPHCRRLQ---LKDLLVSEMQRLTKYPLLLDNIIKYTETSSPDLPLLRRAQACCR 910

  Fly  1641 KVAEHINEMQRIHEEYGAIFDHLFRQHQKSCK---------------QPIDLSPGDLLYYGGVEW 1690
            .:.:.:||..|..|.     .||..|:|:...               :.:||:...:::.|.:.|
Zfish   911 GILQEVNEDVRETEH-----RHLLSQYQRRLDATPLERLANPVAAQFRNLDLTTKRMVHEGPLTW 970

  Fly  1691 ------------LNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEV 1743
                        |.:||.|..:::|.:         ..::..|..|     .|.||:        
Zfish   971 RVGKDKAIEIQALLLSDLLLLLQRGPD---------DRLILRCPSR-----SLGGVT-------- 1013

  Fly  1744 EIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQR----RSEKVYVLSNSTAD------ 1798
                                  |:.:.|. .::.|.|.|.|    .::.:||:|.|...      
Zfish  1014 ----------------------DLKTPFC-PVVCLDSCLVRPVATDNKALYVISTSERQIYELVA 1055

  Fly  1799 --------FRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTL--- 1852
                    :::...|||....:......:.|.....|:...:|...|:|..|..||.....:   
Zfish  1056 GTLLEKNTWKDQLEKTISAAAQGGSTKPNTPRFRSPGAGVRLSADQSEGSESRMYPDREDEMVLS 1120

  Fly  1853 ----------ERPKQQITIVHGSHTLGKP----KKKSGSQRHSAGNID------YDNLSG--SQE 1895
                      |.|.:.            |    |.|:|....:..:::      :.:|..  ||:
Zfish  1121 PVVTPADAAEECPDED------------PDPGQKNKAGVAESALQDVETLRQLIFRDLEDGWSQD 1173

  Fly  1896 ADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQ 1960
            :||.|            |:....:.:.|..|.   |:.:    |.|.|.:...|.:::       
Zfish  1174 SDDTP------------TNETANERSPFTDRP---GNES----SDPAPSESSSQWEEE------- 1212

  Fly  1961 GHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLG-RTPN 2024
                        |.|.||..:.||.:.                        .:|....:| ..|:
Zfish  1213 ------------PVEAPPLEVLQPAVQ------------------------VVRKAVGVGCSLPD 1241

  Fly  2025 HLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVAASFN 2089
            .:|...|::.|....|:...|:.|:....|              |||..:...::|.:..::|  
Zfish  1242 DITDDVTASQSSEDGGNLFYLVMSTDQVVS--------------DESTTDELKDLHHSVFSSS-- 1290

  Fly  2090 LSLGSSGSLFASDARDNQT-------QSRTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFES 2147
                     |.::..:..|       ||..:||.|  .|...||.....|...|...|:....|.
Zfish  1291 ---------FINEEEEQDTPCLSPTDQSLIESQGH--RPGLSQSQSSVQRHVIKNVDEIFNTMEE 1344

  Fly  2148 EAERLAASQQVAVVHQHPSDQARESGHKQRRDRDRNPTETDATARFMDKHLSDLEQENLTDGTCD 2212
            ..::|          ||..|  .|:.|.:...:.|.|..       :||..||...::.|     
Zfish  1345 LMKKL----------QHLRD--IEADHHKLLKKLRKPLP-------VDKMSSDGVHKSPT----- 1385

  Fly  2213 IVAYMESLREKAFDPQDLAEDTGDHQQNDSSLSPEPQTIVENT 2255
             .|.:.||...|          ||.::..|:...:||  :::|
Zfish  1386 -AARLSSLDRGA----------GDGKEGVSTEPAQPQ--IQST 1415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 22/127 (17%)
PH 873..974 CDD:278594 22/103 (21%)
TIAM1_RBD 1141..1219 CDD:176413 24/105 (23%)
PDZ_signaling 1221..1308 CDD:238492 20/142 (14%)
RhoGEF 1456..1647 CDD:238091 42/232 (18%)
PH2_Tiam1_2 1650..1823 CDD:269957 34/217 (16%)
PH 1693..1812 CDD:278594 22/136 (16%)
arhgef11NP_001027010.1 PDZ_signaling 49..123 CDD:238492 18/112 (16%)
DegQ <71..140 CDD:223343 23/118 (19%)
RGS_PDZRhoGEF 300..446 CDD:188707 34/156 (22%)
RhoGEF 737..918 CDD:279015 41/201 (20%)
PH-like 935..1075 CDD:302622 27/184 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.