DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and arhgef18b

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_690750.6 Gene:arhgef18b / 562264 ZFINID:ZDB-GENE-070705-462 Length:1059 Species:Danio rerio


Alignment Length:1291 Identity:260/1291 - (20%)
Similarity:443/1291 - (34%) Gaps:365/1291 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1308 RSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAES 1372
            |||||  |.....:|   |...:|.    |.|..........|:.||..|          |.|: 
Zfish    14 RSSRT--PASQSPLR---DPCTALT----PIDGSSRLSRCSAGMTVPHKG----------PSAQ- 58

  Fly  1373 SPATSFVDPAAMAAQLAVGGVGGVV--VGGLGVAKPTSRTSSF----------------EIENLL 1419
             ||:| .:|:|.....:.|.:.|.:  :....|.:|...|.|.                .:.:.|
Zfish    59 -PASS-SNPSASQNSSSSGSITGEMDEIDAFRVRRPADDTVSLASTVPESLIVEDAHYATVRSEL 121

  Fly  1420 KTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEP 1484
            :...|:....|.:.:|....|.|      ...:|.|.:.|:.||:.||..:|:.|..:|..|...
Zfish   122 EALAQDFEVESWSLAVDQHFSKT------HSKEAIKRQDVIYELIQTEIHHVRTLKIMLRVYARE 180

  Fly  1485 MKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESL--DLEPDFNKFEHCGQFRNVLFAIGSAF 1547
            ::....|....::.||..:..::.....||..|.|..  .|:|        |..||  :||....
Zfish   181 LREALQLDERRLDCLFPRLDSLLELHNHFLSRLRERRVESLQP--------GSERN--YAINKLS 235

  Fly  1548 LYYVNHF---------KLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSST------- 1596
            ...::.|         :.|..||:.|::|  |.|..|...:.::|   :|..::.|:.       
Zfish   236 DILISQFSGELGDRMKESYGDFCSRHTEA--VNHYKEQLQSNKKF---QNLMRKLSNLSIVRRLG 295

  Fly  1597 LESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEE------ 1655
            :...::...|||.|||:||:::.:.|:...:||..|.:||..::.|...::....::|:      
Zfish   296 VPECILLVTQRITKYPVLLERILHNTEAGTEEHEGLAQALGLIKDVIVQVDAQVSLYEKEARLRE 360

  Fly  1656 ---------YGAIFD-HLFRQHQKSCKQPIDLSPG--DLLYYGGVEWLNISDFLGKIKKGLELHA 1708
                     .|.|.| .:||:.        |||.|  .||:.|.|.|...|   |::|..|.|  
Zfish   361 IASKMEPKSLGKIKDGRVFRKE--------DLSQGRRKLLFEGTVNWKAAS---GRLKDILAL-- 412

  Fly  1709 MCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLW 1773
               :....:|.|      |:|....|.| ...|:..:|..|.|| |.||      |.:..:.|  
Zfish   413 ---LLTDVLVLL------QEKDQRYVFS-TVDNKPSVISLQKLI-VREV------AHEERAMF-- 458

  Fly  1774 ELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQ 1838
             ||...|    ...::|.:..::.:.||.::..|||.:.      |.|             |:.:
Zfish   459 -LICASS----NEPEMYEIHTASKEDRNTWITHIRQAVE------SCP-------------HTEE 499

  Fly  1839 GMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDN---LSGSQEADDLP 1900
            .:.|          |..:.::..|.                      :|..   |..:|....|.
Zfish   500 RLFS----------EEEEARVARVR----------------------EYQERLALKDAQITQSLA 532

  Fly  1901 PSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHA 1965
            ..:.:....|....|  ::.:|.|.|....||.:::               ||.:.|::..    
Zfish   533 EKLQLFAELSECVAG--LEDSGSRSRLLLRGDTSDL---------------QQGETLLKAA---- 576

  Fly  1966 HPHPHPHPREPPPPPIRQPHLHHHSSDIERIDP--GTKSEGEEDSQQGTIRPKATL--------- 2019
                                    .:::|.:..  .::..|.....:|...|..:|         
Zfish   577 ------------------------ITEVENLQNLLTSRVRGTSAQTEGNQSPSLSLLPRRADTFG 617

  Fly  2020 GRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQV 2084
            |...|...|....::.....|:..|....|. .||..|.|.:..  ...|..||:..|...:..:
Zfish   618 GYDSNSSALPKNGSIKKKGPGAGGRTRDRSQ-RASSDPQLKEVF--TCQDHDELDEASSPASTNM 679

  Fly  2085 AASFNLS--------LGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPRQSPR------QSP 2135
            .:|..|.        |..|..|::..|..:|..|..:.|..|:..:.|:.|....|      :..
Zfish   680 WSSCKLPESELYERVLLLSQRLYSLQAIISQQDSHIELQRASILTAERERPGSRTRGTDVLLEQE 744

  Fly  2136 KQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHKQRRDRDRNPTETDATARFMDKHLSD 2200
            ||     ...|...|.||..|::.  .||..:|||   .::.|::.|...|.|      .:.|.:
Zfish   745 KQ-----RNLEKHREELANFQRLQ--SQHRQEQAR---WEREREKQRRLAEAD------QQRLKE 793

  Fly  2201 LEQE------NLTDGTCDIVAYMESLREKAFDPQDLAEDTGDHQQNDSSLSPEPQTIVENT-QQT 2258
            .|:|      .|.:...::....::.::   |.:.|.|.|...::....|..:.:....|| ..|
Zfish   794 REEECRRLETRLAEERLELERQRQTYQQ---DLERLRESTRAVEKEKERLEQQRKLKKHNTVPNT 855

  Fly  2259 VVVDIESPSRPATESDSTGN--TTGPSERSGDETEEEATTSSLASHIVVIDKKVDKIFKAKSPER 2321
            ..:..:..::.:|.|...|.  ..|..|::  ..::....:||::.            .|..|||
Zfish   856 AALYTQELTQLSTSSSFNGEFLLGGAGEQT--HPQKSLLRASLSAS------------PADYPER 906

  Fly  2322 PASTKVKGGRRQIYISPDRCKSQGSSPVRIIKIKSPRTSLSDQGK-------RLSVCSSRDNSQD 2379
            |   :|...|..   |.:...::...|:.:|   |....|..||.       :|:..|.......
Zfish   907 P---EVHSRRES---SCNTLPAKTEVPIHLI---STTNQLHKQGSVQQQIPTKLAALSKGKEKSG 962

  Fly  2380 RLSAGRRTPS--------------PRRSSEGGGILKHTTGPDPGILKPPSSPAKSKSPDRSCLKK 2430
            :..:..||.|              ..|.|:||    |.|       :.|.||.:           
Zfish   963 KGKSSHRTDSLASVDMKQMLPIKLSARDSDGG----HKT-------RRPISPHQ----------- 1005

  Fly  2431 GGPSHVCSVETLSPRVSPRGSMDHLSP----DRGMTSSSCLRHSPRSSFDSHGESD 2482
              |.|..| ::|||..:...:...|:|    ....||...|   |.:..|...:.|
Zfish  1006 --PQHSHS-DSLSPPDAYSDAQSSLAPALPKTHNQTSQQTL---PYTVSDEAAKED 1055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492 260/1291 (20%)
RhoGEF 1456..1647 CDD:238091 50/208 (24%)
PH2_Tiam1_2 1650..1823 CDD:269957 47/190 (25%)
PH 1693..1812 CDD:278594 30/118 (25%)
arhgef18bXP_690750.6 RhoGEF 152..346 CDD:238091 50/208 (24%)
PH-like 388..497 CDD:302622 37/156 (24%)
PH <438..492 CDD:278594 18/67 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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