DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sif and arhgap23b

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_690730.6	Gene:	arhgap23b / 562244	ZFINID:	ZDB-GENE-081031-78	Length:	1070	Species:	Danio rerio

Alignment Length:	1177	Identity:	221/1177 - (18%)
Similarity:	367/1177 - (31%)	Gaps:	349/1177 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 SGVNTNTPGVIVTGVGNVGSDMCGQNHVGSQVGNDDPAACQMDMDLSKSEGTQAGGGLHQSVGTC 342
            |..|||.            .|....|..|.|....:|      :|....:..:..|..||: |.|
Zfish    55 SAFNTNL------------KDEENGNGKGGQQFRFEP------VDTIFVKNVKEEGPAHQA-GLC 100

  Fly   343 TSSS----KGTGTRNKDFG---------------------DDMTRDAHSHDMHQHNVINNNTRRK 382
            |...    .|.....|.|.                     :|:.:.|:|.|.:
Zfish   101 TGDRLVRVNGESVLGKTFSQVIALIQNSDNVLELSIMPKDEDVLQLAYSQDAY------------ 153

  Fly   383 TKSTEDMNVDTSTLKRMLKPMPSTESPVTSPEMGRRRYNYYNANAAQTLGHPPHMH---QHGMAM 444
            .:..|....:|..|.   .|.|.......||...:......|.|:...:...|..|   :|.:..
Zfish   154 LRGNEPYTGETQNLP---DPPPVCNLNSKSPSTSQNHAIPVNMNSEIVVVSQPSPHCLIRHRICS 215

  Fly   445 GMGGGGGG--GHHIMNNNTMGRASSQSSRFSGSRSSHEIGRGYPPRNLYLELERERSCIEGSPPS 507
            ...||...  ..|..|:|         :..:.:...|       ||...|.......|.:|
Zfish   216 SSSGGKTNLLDFHFANHN---------AAIASASLVH-------PRKASLPQGHSELCHQG---- 260

  Fly   508 DNVMFDNQCYATTPSSSNGNSDQDQSYGQQQ--SSGQHPQQQQGPPQRSSRHQH--HHQQAPNVT 568
                ..:..|:....||.|||...||..|.:  ..|..|...:|....:|....  |:.....:.
Zfish   261 ----LSDWYYSQVDQSSLGNSHHYQSSSQDRLYELGLAPGGSRGGRTHNSSQDALLHYSAVMGIH 321

  Fly   569 PTPGSP------TSRLLLEYEMH--LRNTLAKGMDAESYSLHTFEALLSQSMENLEFAESLPGSN 625
            .:|.:.      ||:|    ..|  ..|.||      :|:  ::|.....|:|.||.|..|..
Zfish   322 HSPCTDSYGLGRTSKL----SSHSCSENLLA------AYA--SYEQSFGHSLETLEKASILIS-- 372

  Fly   626 QRSPYPLRRPNAKSSTLPLPPHRPLSTIRDKERDRDRDGYYSDRNELIRERERERDRGYLSDHNS 690
                     |:.|   :|..||                    :..:|||..|.:      |..|:
Zfish   373 ---------PHYK---IPTQPH--------------------EITQLIRVAECK------SIANN 399

  Fly   691 SFSNSRCASCIGESAR-----AQWFRHSDGWRSGSSTIGSGSGHGMMTQQI---------PGSGH 741
            ..:.|......||..|     |...||..........:|.   |..:.:.|         |.:..
Zfish   400 HTNGSAVLQPSGEGLRQKQQPAVHIRHLPAQYVEGQMVGC---HTSIPKTIPLQNPSSITPSAAE 461

  Fly   742 KRSPWDSLPSLRQDSSLN-----DSG-----------YKSARADSLEQRAEF------------- 777
            .:.|..||.::..:..|.     .||           .|...|..|..|:|:
Zfish   462 SQEPQRSLVTVFTEEPLQLKKNLPSGIETHHCTSVNFIKPLSAKVLPSRSEYSVHKTNSGITPSS 526

  Fly   778 IRQDSL-----RSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDDRMSL-----TTAVSD 832
            :.||||     :......|.|.|    ..:|.:..|:.|....:...:::|:.|     ..:...
Zfish   527 VEQDSLAVIPFKGSLKKSRRSSY----MLAITTERSKSCDEGLNTFREEERVLLKLPKRVKSFFT 587

  Fly   833 EDDGESV-MASPYKAKATGTA-ASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVC 895
            :|..||: :|....:|...|: ..:.|.|. :||.|:|..|:.|..|:.::. :..|.||..:..
Zfish   588 DDSLESLKVAEDAHSKRHSTSELGNINLTD-IRKQGWLHYKQILNDKRKKVG-SGMRQWKRVFSV 650

  Fly   896 LKGTTLLFYPCDSREG-RSVEAAPKH---------LIIVDGAIMQPIPEHPKRDYIFCLSTAFGD 950
            |..:.|..|. |.||. .....|..|         .|.:.|.::.......||.:.|.|.|....
Zfish   651 LHSSLLFLYK-DKREAVLHATRAGSHGIGQEKDIQTISIQGCLIDIAYSETKRKHTFRLMTQDFC 714

  Fly   951 AYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLH-------LLQEEIFRLEKAIESDHKLK 1008
            .||.||..:.::..|:..|         |.:.||....       |:.:::...:|...:.:|..
Zfish   715 EYLLQAEDRDDMLMWIRVI---------REKSKTENEELGFSRQVLISKKLNDYKKQSPTSNKPD 770

  Fly  1009 HMAELQQ-------------SVVT-----DQETRHQIQTQILQWEENL----ERLHCEQFRLR-- 1049
            ...::.|             |.|:     |:..|       ..|..|:    :::..:.|.:|
Zfish   771 TSPKMHQMMPPFFLSKTENASAVSKAPGKDESIR-------AAWGINIKKKGKKMSPKTFGVRLE 828

  Fly  1050 -CYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKR 1113
             |..|:  |.:.. |:.:.|..|...:..|...|::.|...:..:.:....|...::......:.
Zfish   829 DCLPAA--SNKFV-PQIVETCCSLVEEMGLEYTGIYRVPGNNVMVSSLQEQLDKGMVIDTAEERW 890

  Fly  1114 RPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNPM 1178
            :...:..|...|..|.:       ||..|    .|:.|:...  ||..:|:      ....|..|
Zfish   891 KDLNVISSLLKSFFRKL-------PEPLF----TDDKYNDFI--DANRLED------TGDRLKTM 936

  Fly  1179 EHFVRVKKRRDMEDHNY----FVPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQM----- 1234
            ...:     ||:.||||    |:......:.::...::.....:.:::...|.||:.:.|
Zfish   937 RKLI-----RDLPDHNYHTLKFLIGHLKTVADHSEKNKMEPRNLALVFGPTLVRTSEDNMIEMVT 996

  Fly  1235 -----------------WGFSVEAELIENAERQ-----------DELCCYVSRV----------E 1261
                             |.||.:.:..:..|.|           |.|...:.||          .
Zfish   997 HMADRYKITETLILHHTWFFSDDLDTDKTPEDQKQKEMQPVLNIDHLLSNIGRVVPLQDFSAERM 1061

  Fly  1262 DKSVAMH 1268
            |:|:..|
Zfish  1062 DQSLRFH 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	33/134 (25%)
		PH	873..974	CDD:278594	26/110 (24%)
		TIAM1_RBD	1141..1219	CDD:176413	15/81 (19%)
		PDZ_signaling	1221..1308	CDD:238492	16/91 (18%)
		RhoGEF	1456..1647	CDD:238091
		PH2_Tiam1_2	1650..1823	CDD:269957
		PH	1693..1812	CDD:278594
arhgap23b	XP_690730.6	PDZ_signaling	29..136	CDD:238492	19/99 (19%)
		PH	618..735	CDD:278594	31/127 (24%)
		PH_ARHGAP21-like	619..740	CDD:269955	33/131 (25%)
		RhoGAP	822..1016	CDD:295372	37/220 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910