DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and arhgef2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_021328624.1	Gene:	arhgef2 / 561276	ZFINID:	ZDB-GENE-030717-1	Length:	872	Species:	Danio rerio

Alignment Length:	847	Identity:	154/847 - (18%)
Similarity:	271/847 - (31%)	Gaps:	343/847 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1409 RTSSFEIENLLKTAE----------QETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMEL 1463
            |..:..:|:|....|          :...|.....|.:.:|.::.|...|:  |..|.:.|:.||
Zfish   189 RNRAMSMESLNDEGETYYTSMMEELERDGKDFAADSWSLAVDSSYLQSQRK--DVIKRQDVIYEL 251

  Fly  1464 VDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNL--EESLDLEPD 1526
            :.||..:|:.|..:...:...|..|..:....::|:|..:.:::.....||..|  ..|..|..:
Zfish   252 IQTEFNHVRTLRIMEGVFRRGMLEEVMMEMGVVHAIFPCLDQLLLIHTNFLSQLLQRRSNSLASN 316

  Fly  1527 FNKFEHCGQFRNVLFAIGSAFLYYVNHF---------KLYSSFCASHSKAQKVLHPNEGNHALQE 1582
            .|        ||  |.|.......|..|         |.|..||:.|.||.|:         .:|
Zfish   317 SN--------RN--FTIQKLGDILVEQFSGQNAEDMRKCYVEFCSRHLKAVKL---------YKE 362

  Fly  1583 FLAARNPKQQ------HSSTLESY-----LIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEAL 1636
            .||.....||      ..|.|..:     ::...|||.|||:|:|::.:.|....:|...|.::|
Zfish   363 LLARDKRFQQFIRRVSRGSLLRRHGVQECILLVTQRITKYPVLMQRILDNTKGNEEESKSLAQSL 427

  Fly  1637 KGMEK----VAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFL 1697
            ..:.:    |.:.:.|::|             .|..:..:..:|......:..|||       |.
Zfish   428 TLIRELLCSVDQQVQELER-------------AQRLQEIQSRLDPRAETKVKGGGV-------FH 472

  Fly  1698 GK--IKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVR 1760
            |.  :::|| :|....::|:|          |..:|..|              .||: :|:|.|
Zfish   473 GAELLRRGL-IHEGALLWKTA----------QGSRLKDV--------------HVLL-MTDVLV- 510

  Fly  1761 ASSAKDMDSHFLWELIHLRSQL------------QRRSEKVYVLSNST-----------ADFRNA 1802
              ..::.|..:::..:...|.|            |:|.  ::::|:||           .|.||.
Zfish   511 --FMQEKDQKYVFPTLDKPSVLCLQNLIVRDIANQQRG--MFLISHSTPPEMYELHAASKDDRNT 571

  Fly  1803 FLKTIRQ--------------------------------------IIRESVRNMSIPMKNFGGSS 1829
            ::|.|:|                                      :::|.|...|..::..||.:
Zfish   572 WMKIIQQTVSNCPSREDFPLIETEDKALLRRLRADIQQKDREVLELLQERVTLFSDLVEATGGQN 636

  Fly  1830 GSVSGHSSQGMGSMGYPGNSQT----------------------------------LERP----- 1855
            .:|             |.||:.                                  :|||
Zfish   637 VTV-------------PTNSRNIFRADTPYAPQAEKLLNEAIVEVDRLSDVLLSSCIERPQSCRL 688

  Fly  1856 ---------------KQQITIVHGSHTLGKPKKKS----------------------GSQRHS-- 1881
                           |::|: |:|::....|..|.                      .:|.||
Zfish   689 NGEATEVQLTSKTADKERIS-VNGTYDTNGPSNKDRNGNQLLDKLLNEEVCQRLVNLSTQLHSIQ 752

  Fly  1882 AGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQ 1946
            |..|..|:........:..|:.|.              |||      :|||..|:
Zfish   753 AAVIRQDSFLEVYMQKESSPTTGT--------------PAG------SVGDFAEL---------- 787

  Fly  1947 QQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQG 2011
            |::..|.|.::::...|.                                |..:.....:||.:|
Zfish   788 QRKYNQLQGEMIRLQAAQ--------------------------------DKTSNGIPVQDSAKG 820

  Fly  2012 -TIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDESELES 2075
             ..|.|.|          |..||..:.....:.:::.|   |.:..|..::|:    |:|||..:
Zfish   821 QDKREKLT----------SKESTEQLDGKQEEGKMVMS---PRADSPRDLQDI----PEESECGT 868

  Fly  2076 ES 2077
            |:
Zfish   869 EA 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	51/216 (24%)
		PH2_Tiam1_2	1650..1823	CDD:269957	38/235 (16%)
		PH	1693..1812	CDD:278594	29/181 (16%)
arhgef2	XP_021328624.1	C1	47..92	CDD:237996
		RhoGEF	244..438	CDD:238091	50/212 (24%)
		PH-like	478..595	CDD:327399	27/147 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910