DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and fgd1

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_688794.4	Gene:	fgd1 / 560305	ZFINID:	ZDB-GENE-081104-33	Length:	995	Species:	Danio rerio

Alignment Length:	639	Identity:	126/639 - (19%)
Similarity:	242/639 - (37%)	Gaps:	163/639 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1212 EFVEVCMKI-------LYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHN 1269
            ||:..|..:       |.:.||::...|:    ..|.::.|..|...||....|   ||.::|.:
Zfish   219 EFILPCTSLQEPLEAPLAEDELEKEEKEE----EEEEDVDETEEDDSELGASCS---DKRLSMES 276

  Fly  1270 GIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCP 1334
            |....|:::       .:::|...:|.:..:: ||:       .|..:.|.:...|..|||:..|
Zfish   277 GYGASDKLL-------DNMEMTANQSEIPSDR-LSL-------PPAQMDGKLANRDSGIDSISSP 326

  Fly  1335 PPPTDPPVMSEEMITG---LIVP-APGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGG 1395
            ....:...:.:|...|   .|.| :||...:...:..|:.|                    |.||
Zfish   327 SHSEELCFVGDEDRVGHEREICPCSPGPGISCSYVEGPDEE--------------------GAGG 371

  Fly  1396 VVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTP--------SRQLTD 1452
            ...|                    :.:|.::.....:|. .|.::..||.|        |.:::.
Zfish   372 EEAG--------------------RDSEGDSDLEEGSGD-ESEMNPMALQPLPKAERQDSTEMSV 415

  Fly  1453 AEKLRKVVMELVDTERTYVKHLNNLLEHY----LEPMKRETFLSNAEINALFGNIHEIVTFQRQF 1513
            .:::..:..||:.||:.||..|:.|.:.:    :|..:..:......:..:|.||..|..|.:||
Zfish   416 QQRVFNIANELLHTEKAYVSRLHLLDQVFCAQLMEEARARSSFPCEMVMGIFSNICSIYCFHQQF 480

  Fly  1514 ----LQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHF----KLYSSFCASHSKAQKV 1570
                |:...|..||.|      ..|.....|......:..||.:|    :|.:::....|:.:.:
Zfish   481 LLPALEKRMEEWDLNP------RIGDILQKLAPFLKMYGEYVKNFDRAMELVNTWMQRSSQFKTI 539

  Fly  1571 LHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEA 1635
            :|    |...:|...        :.||:.::::|:|||.:|.|||:...:.....||:.....::
Zfish   540 IH----NIQKEEMCG--------NLTLQHHMLEPVQRIPRYELLLKDYLHRLPEDADDFKDAQKS 592

  Fly  1636 LKGMEKVAEH----INEMQR------IHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEW 1690
            |:.:...|||    |.:|:|      ::|..|.             ::.|.....:|:..|.:
Zfish   593 LELIATAAEHSNAAIRKMERMRKLLKVYELLGG-------------EEDIVNPTNELIKEGHI-- 642

  Fly  1691 LNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVT 1755
            |.:|     .|.|........:|...::: |..:||...:..||.::              |.|.
Zfish   643 LKLS-----AKNGTSQDRYLILFNDRLLY-CVPKLRLIGQKFGVRAR--------------IDVD 687

  Fly  1756 EVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQ 1809
            .::::.:|:.::...||........:||.|:|:      ...|:..|...||::
Zfish   688 GMELKETSSMNVPRTFLVSGKQRSLELQARTEE------EKRDWIQAIQATIQR 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413	3/6 (50%)
		PDZ_signaling	1221..1308	CDD:238492	19/86 (22%)
		RhoGEF	1456..1647	CDD:238091	47/206 (23%)
		PH2_Tiam1_2	1650..1823	CDD:269957	29/166 (17%)
		PH	1693..1812	CDD:278594	22/117 (19%)
fgd1	XP_688794.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910