DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and arhgef9a

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_005165263.1 Gene:arhgef9a / 559868 ZFINID:ZDB-GENE-070705-271 Length:549 Species:Danio rerio


Alignment Length:513 Identity:127/513 - (24%)
Similarity:212/513 - (41%) Gaps:102/513 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly  1350 GLIVPAPGWNGTSKDLYSPEAESSPATS----FVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRT 1410
            |.|....||...|    ....||.|..|    :::|.| |::|                  |:.|
Zfish    48 GQIDEEEGWFPAS----FVRVESHPPQSKQLFYINPVA-ASRL------------------TNAT 89

  Fly  1411 SSF----EIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLR-KVVMELVDTERTY 1470
            :..    |....::.||..:...:.....:.:.||..|...:...:.:::| .|:.|::.|||.|
Zfish    90 AKLWVNQEENTAVEVAESSSEVQNGHAEASPNPSTDCLCLGQPTQNRDQMRANVINEIMSTERHY 154

  Fly  1471 VKHLNNLLEHYL-EPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFE-HC 1533
            :|||.::.|.|| :..||....::.::..:||||.:|..||..|::      |||..||..| | 
Zfish   155 IKHLKDICEGYLRQCKKRRDMFNDDQLKVIFGNIEDIYRFQLSFVR------DLEKQFNTEEPH- 212

  Fly  1534 GQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFL-AARNPKQQHSSTL 1597
                  |..||..||.:.:.|.:||.:|.:|..|...|.....:...|.|. |.|..:|.....:
Zfish   213 ------LSEIGPCFLEHQDGFWIYSEYCNNHVDACMELTRLMRDARYQHFFEACRLVQQMIDIAI 271

  Fly  1598 ESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDH 1662
            :.||:.|:|:|.||||.|.::...|.....::.::..||..|..|.:.|||.:|..|....|   
Zfish   272 DGYLLTPVQKICKYPLQLAELLKYTVQEHSDYRYVAAALAVMRNVTQQINERKRRLENIDKI--- 333

  Fly  1663 LFRQHQKSC-----KQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCK 1722
              .|.|.|.     :..:|.| .:|:|.|.:.|:       ....|.....:.|:|...:| |||
Zfish   334 --AQWQASVLDWEGEDILDRS-SELVYTGEMSWI-------YQPYGRSQTRIFFLFDHQMV-LCK 387

  Fly  1723 ERLRQKKKLMGVSSKNATNEVEIIRYQVLIPV----TEVQVRASSA-----KDMDSHFLWELIHL 1778
            :.|.::..|.      ....:::.||:|:..:    .:..|...:|     :|.|...|:    |
Zfish   388 KDLIRRDILY------YKGRIDLDRYEVIDAIDGRDDDFNVSVKNAFKLANRDTDEIHLF----L 442

  Fly  1779 RSQLQRR--------SEKVYVLSNSTADF-------RNAFLKTIRQIIRESVRNMSIP 1821
            ..:|:.:        .|:..|..:....|       |.|.| |:|:..::.....|:|
Zfish   443 PKKLEEKIRWLRAFQEERKMVQEDEKIGFEISQYQKRQAAL-TVRRATKQKGVGRSVP 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 62/194 (32%)
PH2_Tiam1_2 1650..1823 CDD:269957 41/201 (20%)
PH 1693..1812 CDD:278594 27/142 (19%)
arhgef9aXP_005165263.1 SH3_ARHGEF9_like 13..64 CDD:212762 5/19 (26%)
RhoGEF 143..322 CDD:279015 62/191 (32%)
PH_Collybistin_ASEF 327..466 CDD:269931 32/162 (20%)
PH 372..458 CDD:278594 18/96 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.840

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