DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and vav3b

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_005163380.1 Gene:vav3b / 559145 ZFINID:ZDB-GENE-070912-251 Length:853 Species:Danio rerio


Alignment Length:630 Identity:126/630 - (20%)
Similarity:233/630 - (36%) Gaps:159/630 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1362 SKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFE-----IENLLKT 1421
            ||..|:|.|:.|...||                           ||..::..|     :.:|:..
Zfish   113 SKLSYTPVAQQSGIRSF---------------------------PTEESTENEDIYIHLADLIDE 150

  Fly  1422 AEQETRKSSPTGSVTSS------VSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEH 1480
            ..:|.......|.:...      :.|.|.....:..:.:.....::|:..||..|.:.|..:.::
Zfish   151 ELEEDVYDPVYGDIEGGEVYEDLMRTEAAVSQAKQAEVDIRSCCLLEIKQTEAKYTETLETIEKY 215

  Fly  1481 YLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNV--LFAI 1543
            ::.|:.:  |:...:|:.:|.||.::|...:..:..:::             |.|.:|.  |..|
Zfish   216 FMIPLMK--FIPATDIDKVFINIPDLVKVHKGLMGEIQD-------------CVQNKNAENLHQI 265

  Fly  1544 GSAFLYYVNHFKLYSSFCASHSKAQKVL----HPNEGNHALQEFLA--ARNPKQQHSSTLESYLI 1602
               |:.|.:...||..:|:....|..:|    ...||.....|..:  |.|.|    .||...|:
Zfish   266 ---FITYKDRLLLYGKYCSHVESAISLLDFICKEKEGVRLKLEECSKRANNGK----FTLRDLLV 323

  Fly  1603 KPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQH 1667
            .|:||:||||||||::...|:. ..|..:|..||..|..:|:::||::|..|....|     .|:
Zfish   324 VPMQRVLKYPLLLQELVKYTND-GPEKSNLRIALDAMRDLAQYVNEVKRDVETLREI-----DQY 382

  Fly  1668 QKSCKQPIDLSPGDLLYYG---GVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKER--LRQ 1727
            |:|    |:.....||.||   |...:.:...|.|.::...:    |:|.:||: :||.|  ..:
Zfish   383 QRS----IENLNQSLLSYGRPKGDGEVRLVSNLDKRRQDRHI----FLFDAAVI-ICKRRGDNYE 438

  Fly  1728 KKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVL 1792
            .|:::.:|....||.:                     .|.|.              |:....:.|
Zfish   439 MKEVIDLSHFKITNNL---------------------ADKDC--------------RKWSSGFYL 468

  Fly  1793 SNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQ 1857
            ::........||...:::.::.:....:.:.|....:.:.:.|..:          ..|.||...
Zfish   469 THQQGQSGFEFLFKTKELKKKWLDQFEMAISNIRPENATFNSHHFR----------MHTFERATT 523

  Fly  1858 QIT---IVHGSHTLGK--PKKKSGSQRHSAGNIDYDNLSGS-------------QEADDLPPSVG 1904
            ..:   ::.|....|.  ||..:|:.:...|.:.....:|:             ||...||..:.
Zfish   524 CSSCRMLLRGIFNQGYLCPKCGNGAHKGCLGKLGVCGRTGAAVQKPQRKTTPRKQEDPGLPKMLV 588

  Fly  1905 VVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQ 1949
            :..|..      ..:|.|.:..:..:|||.|:..:  :||....|
Zfish   589 IRDYFG------VSKPQGGQALNAQIGDVIEVVYA--DPHSSWWQ 625

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 51/198 (26%)
PH2_Tiam1_2 1650..1823 CDD:269957 31/177 (18%)
PH 1693..1812 CDD:278594 19/120 (16%)
vav3bXP_005163380.1 CH 4..115 CDD:278723 1/1 (100%)
RhoGEF 194..368 CDD:279015 51/196 (26%)
PH_Vav 381..503 CDD:269930 29/165 (18%)
PH 406..499 CDD:278594 19/132 (14%)
C1 511..556 CDD:237996 10/54 (19%)
SH3 585..644 CDD:302595 10/49 (20%)
SH2 653..755 CDD:301589
SH3_VAV3_2 798..852 CDD:212911
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.940

Return to query results.
Submit another query.