DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and arhgef4

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_009296712.1 Gene:arhgef4 / 559017 ZFINID:ZDB-GENE-070912-575 Length:3088 Species:Danio rerio


Alignment Length:2190 Identity:407/2190 - (18%)
Similarity:690/2190 - (31%) Gaps:830/2190 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   223 VDGQQQVGSGKVVSAV-SSTSLYDNVASGGPGTNQGADTL-PRQMKGG-----QQDRQDVANSGV 280
            :||.|...|..::... |..|:.||.:......:|..||: |.|.:..     .||.||.::| .
Zfish  1058 LDGVQYDQSKILIEQTQSQDSVKDNPSQDLVKHSQSQDTVEPSQSQVSVEHIQSQDSQDCSHS-Q 1121

  Fly   281 NTNTPGVIVTGVGNVGS-DMCGQNHVGSQVGNDDPAACQMDMDLSKSEGTQAGGGLHQSVGTCTS 344
            |:.......|.||...| |:..|:.        .|||.:.....:..|.:       ||:.:...
Zfish  1122 NSTVHSQSQTSVGQSQSQDLVEQSR--------SPAAAENSQSQTSVEHS-------QSLDSVEH 1171

  Fly   345 SSKGTGTRNKDFGDDMTRDAHSHD----------------------------------------M 369
            ....|...::....::.: |||.:                                        .
Zfish  1172 MKSQTSVEHRQSQVELIK-AHSMNTRWMVTESDTVAFYDKVRLKQDCMDVCADCEVVESLGVLSK 1235

  Fly   370 HQHNVINNNTRRKTKSTEDMNVDTSTLKRMLKPMPSTESPVTSPEMGRRRYNYY-NANAAQTLGH 433
            |..|:...|..|....|:|:| ||              |||.|      .|..: :...|.::|.
Zfish  1236 HADNLNFENNERLNFKTQDLN-DT--------------SPVVS------EYECFPHVPNASSIGV 1279

  Fly   434 PPHMHQHGMAMGMGGGGGGGHHIMNNNTMGRASSQSS----RFSGSRSSHEIGR----GY----- 485
            |..:||              ..|.|:.:..:..:|.|    :....:..:.:.|    ||     
Zfish  1280 PDSLHQ--------------CTISNSPSDLQVKTQQSWPVLQIHTEKDDYSVSRYHMDGYCLQDS 1330

  Fly   486 -----------PPRNLYLELERE---------------RSCIE------------GSPPSD---- 508
                       |...:....:.|               |.||.            |.|..|    
Zfish  1331 EQTEFYKTYQCPNSTINFNTQGEFTEARKVVSTEGVFTRGCINTKLFDGKSVDIVGGPQKDSNKH 1395

  Fly   509 NVMFDNQCYATTPSSSNGNSDQDQSYGQQQSSG----QHPQ------------QQQGPP------ 551
            :||...:| ...||.       :||.....|||    :.|:            :.:|.|      
Zfish  1396 HVMKGKEC-TIVPSI-------EQSVIYSDSSGCIEYKRPKTLSIACPDMTTAESEGCPVDSPVE 1452

  Fly   552 QRSSRHQHHHQQAPNVTPTP------------GSPTSRLLLEYE-----MHLRNTLAKGMDAESY 599
            ..|:..:..|.:: .|:||.            .:..::.::||.     .|..:||:   |.:..
Zfish  1453 SLSTLFEIPHDRS-TVSPTDICFEFSDGPHMNCTQVAQSVIEYSDAPKLFHQFDTLS---DKQRR 1513

  Fly   600 SLHTFEALLSQSMENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTIR---------- 654
            ...:.||:.| :::.|..|.|.|.:|.::|:...:.|:::.|.....:..:..|.          
Zfish  1514 PNESAEAIAS-NVDILSGARSDPFTNAQTPFDYSQVNSRNYTQSSDTNNNIKAITLEECASGVQM 1577

  Fly   655 --------------------DKERDRDRDGYYSDRNEL------------IRERERERDRGYLSD 687
                                .|..|......:|.||.|            :..||.....   |.
Zfish  1578 SLPSSLQKYSRFTNNAECLVSKRGDYKNIDSFSARNTLATPFKAPEMKTEVNSRENVVKS---SS 1639

  Fly   688 HNSSFSNSRCASCIGESARAQ-----WFR-------------------HSDGWRSGSSTIGSGS- 727
            |........|..|.|:..:.|     .|:                   |:|.....:..:.|.| 
Zfish  1640 HIDVTQRKLCDCCGGKECQLQTAGVFQFKGTDAISQRRTAVLQTLSPLHTDDSTHEAVKVDSTSC 1704

  Fly   728 -----------GHGMMTQQ---IPGSG----------------HKRSPWDSL-----------PS 751
                       .|..:.|:   :|.:|                |:..|.::|           |.
Zfish  1705 EFSHMVSLLTHKHPNLVQEDFVLPLTGAHKADDTHVLENMERKHETFPINALKSTESICETSDPL 1769

  Fly   752 LRQDSSLNDSGYKSARAD--------SLEQRAEFIR--QDSLRSEYLSDRESRYGIVQQ------ 800
            .:|...|::|..:.|...        :||...|..|  :.|...|...|.:.|...:.:      
Zfish  1770 FKQTLQLHNSEVEGAFVSCCHILPITNLEAILETDRSPESSFAVENELDEQQRGSPLSEGGLNED 1834

  Fly   801 -ASIESTDSR--------------------------MCYLTSSEISDDDRMSLTTAVSDE----- 833
             :|.|...:|                          |..|::...|.||. |:::.||.:     
Zfish  1835 LSSCEDVKNRPHDSSCDMHTKANVANFMNEPDAGETMNSLSNGFDSSDDH-SVSSLVSQDLDSST 1898

  Fly   834 --DDGESVMASPY------KAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQI--------- 881
              ::.|..|...:      :.|.|.:|..|. .:|.:|...|...|:.|.|.|:::         
Zfish  1899 NSEETEDTMQPSFGLRGNARNKRTQSAKGSM-FSGLIRMPTFRKPKRELKRNKNRVDPKVRASSG 1962

  Fly   882 ------ELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKH-------------LIIVDGA 927
                  |:...|.    ..|.|..:.|:....|:....:....||             .:.|...
Zfish  1963 DGDEQDEMKNNRS----PTCSKSHSSLYKTPISQSADHLTDITKHSDHSNDDVFERAFALNVQNR 2023

  Fly   928 IMQPIPEHP-----KRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTL 987
            .....|:||     ::|         |||..|:|                         |:| |.
Zfish  2024 EKHMQPQHPFEQQQQKD---------GDALSFRA-------------------------GQT-TE 2053

  Fly   988 HLLQEEIFRLEKAIESDHKLKHMAELQQSVVTDQETRH--QIQTQILQWE----------ENLER 1040
            .|.|:..    |:|::.:....:|...:|:.:..|||:  :.|.||||.|          ...:|
Zfish  2054 GLQQKRC----KSIDNLNLRMKLALAHKSISSLFETRYPERDQEQILQLENEDGKTKQSWRKTKR 2114

  Fly  1041 LH--------------CE----QFRLRCYMASLQSGELPNPKSLLT---HVSRPTKNTLNK---- 1080
            .:              |:    |.::.|...:.|:      :|:||   :|....|||.:.    
Zfish  2115 CNEAELCKRTPVPGTVCDKCIHQSQIDCAFCAYQN------RSILTNLPNVQARLKNTCHSDPQS 2173

  Fly  1081 ---------------------LGVF------TVSSFHAFICARSPSLLNNLLAGRGATKRRPPML 1118
                                 .|.|      :|..|.:.:..||.|            ...|.:|
Zfish  2174 LKSAPQEGFEDGKYLEEGEQPCGAFSDSDQASVDGFESSVEDRSLS------------PAHPTVL 2226

  Fly  1119 SRSN--SGSSRRSMQ-MNSRDEP-----------------EKTFKVAMPDNAYSTVYLRDAMSVE 1163
            :.||  |.:..||:. ..:.|.|                 .::|:......|.|...|...:|.:
Zfish  2227 ALSNQMSPTWTRSLSCFETTDTPTRPMSPKPHSPGLGWTQRRSFRYPSRSVASSLCLLGQGVSTD 2291

  Fly  1164 EFLASACARRNLNPMEHFVRVKKRRD----MEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQV 1224
            ..|.......:|.|....:......|    :||.:     .::..:|.|::...:.....:.:..
Zfish  2292 GLLDPPQRPTSLKPRTTQLTTAHSFDSEYLLEDSS-----SDNQSQNSLNSASLISKTEHVQHIT 2351

  Fly  1225 ELQRTTLEQM-----------------------WGFSVEA--ELIENAERQ----DELCCYVSRV 1260
            |.:|...|..                       |..|::.  ||..:.||:    ...|.|.:  
Zfish  2352 EAERRPQENACVLRVKSRDPGTAAPRPMSDLYGWTMSLQGTRELALDLERKTNAHQRSCSYET-- 2414

  Fly  1261 EDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSL------------SMMMRSSRTE 1313
                                    ::|:|.: .:..|.::|||            .:..|.|.|.
Zfish  2415 ------------------------LTDVDNI-RKKKLSKQQSLRQISTSTSERHEKLRARLSLTS 2454

  Fly  1314 PPDLVGI-------MRVTDDMID-----------------------------SLVCPPPPTDPPV 1342
            |.....:       .:.|...:|                             :||....|.|...
Zfish  2455 PEQFPSVPLKDHFFSQSTPVGLDYLGWAHRASFSETNLSAPEKEAHGQVAPLALVITDGPQDKSG 2519

  Fly  1343 MSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGV---GGVVVGGL-GV 1403
            :::|:            |:..|||:....||  ..|..|.....|||:..:   |.|....| ..
Zfish  2520 LADEV------------GSEDDLYNEFRSSS--NRFGHPGGGGEQLAINELISDGSVCAEALWDH 2570

  Fly  1404 AKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSS-----VSTTALTPSRQ-------------- 1449
            .....:...|:..::::..: .|.|....|.|..|     .|...|..::.              
Zfish  2571 VTMDDQELGFKAGDVIEVVD-ATNKEWWWGRVLDSEGWFPASFVRLRVNQDEPMEEYLAHLDGAS 2634

  Fly  1450 --------------LTDAEKLR-KVVMELVDTERTYVKHLNNLLEHYLEPMKRET-FLSNAEINA 1498
                          |...|::| .|:.|::.|||.|:|||.::.|.|::..::.| ..:..::..
Zfish  2635 EGCGASMGGPLGPGLPCKEQMRANVINEIMSTERDYIKHLKDICEGYIKQCRKRTDMFTEEQLRT 2699

  Fly  1499 LFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCAS 1563
            :||||.|:..||::||:.||:.      ||| ||     ..|..|||.||....:|::||.:|.:
Zfish  2700 IFGNIDELYRFQKKFLKALEKK------FNK-EH-----PHLSEIGSCFLEQQTNFQIYSEYCNN 2752

  Fly  1564 H-------SKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNL 1621
            |       ||..|:      ...:..|.|.|..::....:|:.:|:.|:|:|.||||.|.::...
Zfish  2753 HPNACVQLSKLMKI------KKYVFFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKY 2811

  Fly  1622 TDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAI--------------------------- 1659
            |:.:..::..:..||..|:.||..|||.:|..|....|                           
Zfish  2812 TNPQHRDYKDVEAALNAMKNVARLINERKRRLENIDKIAQWQSSIEDWEGEDVLSRSSDLIFSGD 2876

  Fly  1660 ------------------FDH--LFRQHQKSCKQPIDLSPGDLLYYGG------VEWLNI----- 1693
                              |||  :|      ||:  ||...|:|||.|      :|.:::     
Zfish  2877 LTKISQPQAKGQQRMFFLFDHQLVF------CKK--DLLRRDILYYKGRLDMDEMEVVDVEDGKD 2933

  Fly  1694 SDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRY--QVLIPVTE 1756
            .||...:|..|:|   |......|..||.::..||::.:    :..|:|.|.:::  :....:||
Zfish  2934 KDFNVSVKNALKL---CSPGGEEVHLLCAKKPEQKQRWL----RAFTDEREQVQHDLETGFTITE 2991

  Fly  1757 VQVRASSAKDMDSH--------FLWELIHLRSQLQRRSEKVYVLS 1793
            ||.:.:......||        .|..|:.||:.|.....|...||
Zfish  2992 VQKKQAMLNATKSHPTGKPKALALQHLLALRAPLLHPKTKCLRLS 3036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 26/157 (17%)
PH 873..974 CDD:278594 21/133 (16%)
TIAM1_RBD 1141..1219 CDD:176413 13/81 (16%)
PDZ_signaling 1221..1308 CDD:238492 17/127 (13%)
RhoGEF 1456..1647 CDD:238091 62/199 (31%)
PH2_Tiam1_2 1650..1823 CDD:269957 45/212 (21%)
PH 1693..1812 CDD:278594 28/116 (24%)
arhgef4XP_009296712.1 Ehrlichia_rpt 392..854 CDD:118064
Ehrlichia_rpt 599..>1192 CDD:118064 33/150 (22%)
SH3_ASEF 2546..2617 CDD:212906 14/71 (20%)
RhoGEF 2659..2838 CDD:279015 62/196 (32%)
PH_Collybistin_ASEF 2843..2982 CDD:269931 30/153 (20%)
PH 2871..2972 CDD:278594 25/115 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.840

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