DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and LOC558044

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001093459.1 Gene:LOC558044 / 558044 -ID:- Length:2391 Species:Danio rerio


Alignment Length:2632 Identity:459/2632 - (17%)
Similarity:834/2632 - (31%) Gaps:819/2632 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   375 INNNTRRKTKSTEDMNVDT---STLKRMLKPMPSTESPVTSPEMGRRRYN-YYNANAAQTLGHPP 435
            :|::..|.|....|:..|.   ..|.|:|:.:...:.|  .|..||.|.: ..|.:.|.......
Zfish   103 VNSHLGRVTCRIGDLYTDLRDGRMLIRLLEVLSGEQLP--KPTKGRMRIHCLENVDKALQFLKEQ 165

  Fly   436 HMHQHGMAMGMGGGGGGGHHIMNNN---TMGRASSQSSRFSGSRSSHEI---------------- 481
            .:|...|         |.|.|::.|   |:|...:...||.....|.|.                
Zfish   166 KVHLENM---------GSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLW 221

  Fly   482 ----GRGYPPRNLYLELERER-----SCIEGSPPSDNVMFDNQCYATTPSSSNGNSDQDQSY--- 534
                ..|||..|::......|     :.|.....||.:.|||.      ..||.:.:...::   
Zfish   222 CQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRSDLIDFDNL------KRSNAHYNLQNAFNVA 280

  Fly   535 ----GQQQSSGQHPQQQQGPPQRS----SRHQHHHQQAPNVTPTPGSPTSRLLLEYEMHLRNTLA 591
                |..:...........|.::|    ....:|:..........|....: :|:|.:.....:.
Zfish   281 EKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGK-VLDYAIEADQLIE 344

  Fly   592 KGMDAESYSLHTFEALLSQSMENLE----------FAESLPG-SNQRSPYPLRRPNAKSSTLPLP 645
            |           :|.|.|:.::.:|          .|.||.. .||...:...|      |:..|
Zfish   345 K-----------YETLASELLQWIEQTIVTLNDRQLANSLSAVQNQLQAFNTYR------TVEKP 392

  Fly   646 PHRP--------LSTIRDKERDRDRDGY-------YSDRN---ELIRERERERDRGYLSDHNSSF 692
            |...        |.||:.|.|..::..|       .||.|   |.:.:.|.||:   |:..|...
Zfish   393 PKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERE---LALRNELI 454

  Fly   693 SNSRCASCIGESARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQD-- 755
            ...:.........|....|.:  |.|.:..:.|....|:....:..:..|..      ::..|  
Zfish   455 RQEKLEMLAARFDRKAAMRET--WLSENQRLVSQDNFGVELGAVEAATRKHE------AIETDIQ 511

  Fly   756 -------------SSLNDSGYKS-----ARADSLEQRAEFI------RQDSLRS----------- 785
                         ..|...||..     ||.|::.:..|::      |::.|.:           
Zfish   512 AYGERVAAVEAVARELEAEGYHEVRRVLARRDNVLRLWEYLKELLAARRERLMAHRDLQRLLQEL 576

  Fly   786 ----EYLSDRESRYGIVQQASIESTDSRMCYLTSSEISD-DDRMSLTTAVSDEDDGESVMASPYK 845
                |::.|.:||        ::|.||      ...:.| :|.:...|.|..:     :.|...:
Zfish   577 SYIMEWMEDMKSR--------LQSQDS------GKHLHDVEDLLQKHTLVEAD-----ISAQAER 622

  Fly   846 AKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSRE 910
            .||....|..|                          .:.::.:|              |||.  
Zfish   623 VKAVQATAKRF--------------------------ASNEQSYK--------------PCDP-- 645

  Fly   911 GRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELEN----WVNSIHS 971
                            |:::        :.:..|..|:|:.....|..:|.|::    |......
Zfish   646 ----------------ALVE--------EKVDLLGRAYGELGQLAADRRVRLDDSRRLWQFLWEL 686

  Fly   972 ACAAAFARHR---------GK--TGTLHLL-QEEIFRLEKA----------------IESDH--- 1005
            ...||:.|.:         ||  :..|||| :.|.||.|.|                ::..|   
Zfish   687 GEEAAWIREQEQIISGGDYGKDLSSALHLLSKHEAFRDEMAARYGPLGNSIAGGEALVKEGHVGA 751

  Fly  1006 ---------------KLKHMAELQQSVVTDQETRHQIQTQILQWE----ENLERLHC-----EQF 1046
                           .|:..::|::..:.:....||.||.....|    |.|.::..     ::|
Zfish   752 PEVTERIKDVRAQWSHLEEASQLREQSLNESVAFHQFQTDANDMEAWILETLRQVSSQEVGHDEF 816

  Fly  1047 RLRCYMASLQ---SGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNL---- 1104
            ..:. :|..|   ..|:.:.:||:        ::|::.|.....::     |.||.:...|    
Zfish   817 STQT-LARKQREVEEEIQSHRSLI--------DSLHEQGSLLPEAY-----AHSPQVEGRLPAIE 867

  Fly  1105 -----LAGRGATKRRP--------PMLSRSNSGS---SRRSMQMNSRDEPEKTFKVAMPDNAYST 1153
                 |.|..::.|:.        .|.|.:::..   ..:...:::.:.|.|...:.:....:.|
Zfish   868 QRYEELEGLSSSWRQALDGALALYRMFSEASACQLWVGEKEQWLHNMEIPTKLEDLEVIQQRFDT 932

  Fly  1154 V---------YLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLH 1209
            :         .:.|...|.:.|..: ..||.:.::........| ..|.......|...:|:.|:
Zfish   933 LEPEMNTLGGRISDVNQVAQQLLGS-DNRNKDQIDQTQNQLNNR-WSDFQSLANQRKQALESALN 995

  Fly  1210 NHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGI--I 1272
            ...:...|.:|            :.| ...:.::||:.:........|..::.|...|...:  |
Zfish   996 IQNYHLECNEI------------KSW-MKEKTKVIESTQSLGNDLAGVMALQRKLTGMERDLEAI 1047

  Fly  1273 KG--DEIMVINGAIVSDL---------DMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDD 1326
            :|  |::......:||:.         .:..::.|.:|.::.......|..|...|.|.:|..||
Zfish  1048 QGKLDDLRSEAKKLVSEHPEQEEEIKGQLAEIQEVWEELRATMKRREESLGEASKLQGFLRDLDD 1112

  Fly  1327 MIDSLVCPPPPTDPPVMSEEMITGL-----IVPAPGWNGTSKDLYSPEAESSPATSF------VD 1380
            ....|    ..|...|.||:..|.|     ::..........|.|..:.|...||..      .|
Zfish  1113 FQAWL----SRTQTTVASEDTPTSLAEAERLLAQHEAIKNEVDNYKEDYEKMRATGAEVTQGQTD 1173

  Fly  1381 PAAM--AAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSS---VS 1440
            ...|  |.:|.....|...:..:..::......:|:.:.||:.|:|      ..|.:.|.   :|
Zfish  1174 AQHMFLAQRLQALDTGWHELRRMWESRHCVLAQAFDFQTLLRDAKQ------AEGFLNSQEYVLS 1232

  Fly  1441 TTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHE 1505
            .|.:..|.|               ..|....||     |.:|..|:    .|..:||.:..:...
Zfish  1233 HTEMPSSLQ---------------GAEEAIKKH-----EDFLTTME----ASEEKINGVVESGRR 1273

  Fly  1506 IVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFA-------------IGSAFLYYVNHFKLY 1557
            :|:....:...::|..|...:  :.:...|..|.|.|             .|.....::|. |:.
Zfish  1274 LVSDGNTYADKIQEKTDSIQE--RHQKNKQAANELLAKLKDNRELQHFLQDGQELTLWINE-KML 1335

  Fly  1558 SSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLT 1622
            ::...|:.:|:. ||.....|  |.|:|.....:.....::.          :..:|:::...|.
Zfish  1336 TAQDMSYDEARN-LHSKWQKH--QAFMAELASNKDWLDKIDK----------EGQVLVKEKPELE 1387

  Fly  1623 DTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFD----HLFRQHQKSCKQPIDLSPGDLL 1683
            .|       :.|.|.|::|....:....:...:  .:||    .||.|   || ..:|       
Zfish  1388 QT-------VSETLSGLQKQWVELENTTQAKAQ--CLFDANRAELFTQ---SC-SALD------- 1432

  Fly  1684 YYGGVEWL-NISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIR 1747
                 .|| |||..|.....|.:|       .|..:.|.|.::.:.:  |.|..|    ||:.::
Zfish  1433 -----SWLQNISSQLQSDDFGKDL-------TSVNILLKKHQMLEHQ--MDVREK----EVQSLQ 1479

  Fly  1748 YQVLIPVTE----VQVRASSAKDMDSHFLWELIHLRSQLQ--RRSEKVYVLSNSTADFRNAFLKT 1806
            .|.|....|    |:|.....:..|..         ||||  .:..:.::|::..|...|..|:.
Zfish  1480 SQALALAQEDSGIVEVDGEQRRVTDRF---------SQLQDPLKERRQHLLASKEAHQFNRDLED 1535

  Fly  1807 IRQIIRE------------SVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQI 1859
            ....::|            .:.::.:.||........:.||                  :|:...
Zfish  1536 EILWVKERMPLATSTDHGKDLPSVQLLMKKNQTLQKEIQGH------------------QPRIDD 1582

  Fly  1860 TIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFR 1924
            ...||::.  .|.|:|...|.....:| ..|:..:|...|..|         .|..:.::.|...
Zfish  1583 IQAHGTNM--SPGKESEMDRERRAALD-GRLAELRELWALLIS---------ETEQRNVRLAEAN 1635

  Fly  1925 GRSKTVGDVTEITC--SSPEPHQQQQQQQQQQQ---------QLMQQG--------HAHAHP--- 1967
            ...:...|..|...  ...|.|...:::.:.:|         |:::|.        |..|:.   
Zfish  1636 RAQQFYTDAAEAEAWMGEQELHMMSEEKAKDEQSALVMVKKHQILEQALEDYAQTIHQLANSSRL 1700

  Fly  1968 ---HPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKA------------ 2017
               ..||   |.....:||       :.::::..|.|...||  ::|.::.:.            
Zfish  1701 MVNSEHP---ESERITLRQ-------AQVDKLYAGLKDLAEE--RRGKLQERLRLTQLKREVDDL 1753

  Fly  2018 --------------TLGRTPNHLTL---------STTSTLS---VGSTGSQA-RLIQSSHPPASY 2055
                          .||:...|:|:         ..|||:.   |.:..:|| .||:|.||..:.
Zfish  1754 EQWIAEREVVAGSHELGQDYEHVTMLRDKFREFARDTSTIGQERVDAVNAQADELIESGHPENAS 1818

  Fly  2056 QPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQ----- 2115
            .......|.:...|..||   .:.....:|||:.|      ..|..|||:.....|.:.:     
Zfish  1819 VAEWKDGLNEAWADLLEL---IDTRTQMLAASYEL------HRFHQDAREALGLIREKKETLAGA 1874

  Fly  2116 -----IHSLHPSPRQSPRQSPRQSPKQDIEV----IEIFESEAERLA---ASQQVAVVHQHPSDQ 2168
                 ::::....||      ..:.:.|::.    :...:.:|.||.   |.::...:|:|    
Zfish  1875 ELGRDLNTVQHFLRQ------HTAYEHDVQALSGQVTQVQDDAARLQKAYAGEKADDIHRH---- 1929

  Fly  2169 ARESGHKQRRDRDRNPTE-------TDATARFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFD 2226
                        :|..||       ...|.|.:  .|..:|:....:...|::.:||.:..:.  
Zfish  1930 ------------ERAVTEAWEGLQSATQTRRLL--LLDTVEKFRFLNMVRDLMLWMEGINLQI-- 1978

  Fly  2227 PQDLAEDTGDHQQNDSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNT-TGPSERSGDET 2290
                       |.:||........:|....|.:..:||:.:...|.....|.| ...:..:.||.
Zfish  1979 -----------QSHDSPRDVSSAGLVIANHQDIKSEIETRADSFTACSEMGRTLINNNHYASDEI 2032

  Fly  2291 EEEATTSSLASHIVVIDKKVDKIFKAKSPERPASTKVKGGRRQIYISPDRCKSQGSSPVRIIKIK 2355
            :|                |:|:: :||..|.....:.|....||.:...:.....|.....:..:
Zfish  2033 QE----------------KLDQL-QAKRTEINQKWQEKMDHLQIVLEVLQFGRDASMAESWLAGQ 2080

  Fly  2356 SPRTSLSDQGKRLSVCSS---RDNSQDRLSAGRRTPSPRRSSEGGGILKHTTGPDPGI------- 2410
            .|....::.|..:....|   |..:.::|:||...    |.|:   :.|.||..:..|       
Zfish  2081 EPLVRAAELGSNVDEVESLIKRHEAFEKLAAGWED----RFSQ---LEKLTTLEEQEIQRRREEE 2138

  Fly  2411 ---LKPPSSPAKSK--------SPDRSCLKKGGPSHVCSVETLSPRVSPRG-------------- 2450
               .:||:.|...:        |..|:.|.:         .||:..||..|              
Zfish  2139 ERARRPPTPPPVEEVVQSEINDSAARTSLDQ---------TTLNQSVSVNGVYSDQDTSQGSESE 2194

  Fly  2451 SMDHLSPDRGMTSSSCLRHSPRSSFDSHGESDHNLDVPHG--SRKRSMSAHGSFETGTRPRAQET 2513
            |::....|.|:.|:|  |..|.::....|.::...:...|  .||:.|.:|      .:..|..:
Zfish  2195 SVNGPGRDSGLDSAS--RQDPSATLPGRGGAEGTTEAMEGILCRKQEMESH------NKKSANRS 2251

  Fly  2514 YQ------------YYPVYDNQTCSD--HYVAAAPTG---------------------RYGGGTS 2543
            :|            :|.  ||::.|:  .|....|..                     |.|.|..
Zfish  2252 WQNVYCVLRKGSLGFYK--DNKSASNGIPYHGEVPISLGEAVCEVAHDYKKRKHVFKLRLGDGKE 2314

  Fly  2544 SRSRLSKSLERSTSRDSTTTSSSYGHRAYGVS 2575
            ...:.....|.|:...:..:|.|...|:.|.|
Zfish  2315 YLFQAKDEAEMSSWIRAIQSSMSSSERSPGAS 2346

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 17/139 (12%)
PH 873..974 CDD:278594 12/104 (12%)
TIAM1_RBD 1141..1219 CDD:176413 12/86 (14%)
PDZ_signaling 1221..1308 CDD:238492 13/99 (13%)
RhoGEF 1456..1647 CDD:238091 34/203 (17%)
PH2_Tiam1_2 1650..1823 CDD:269957 39/195 (20%)
PH 1693..1812 CDD:278594 27/124 (22%)
LOC558044NP_001093459.1 CH 94..197 CDD:237981 24/104 (23%)
CH 213..316 CDD:237981 17/108 (16%)
Spectrin 341..451 CDD:278843 28/129 (22%)
SPEC 465..563 CDD:197544 16/105 (15%)
SPEC 568..782 CDD:238103 45/298 (15%)
SPEC 681..888 CDD:238103 39/220 (18%)
SPEC 785..994 CDD:238103 36/224 (16%)
SPEC 997..1201 CDD:238103 39/220 (18%)
SPEC 1209..1419 CDD:238103 46/264 (17%)
SPEC 1420..1635 CDD:238103 55/282 (20%)
SPEC 1636..1848 CDD:238103 40/226 (18%)
SPEC 1849..2058 CDD:238103 44/268 (16%)
SPEC 2065..>2123 CDD:197544 10/64 (16%)
PH_beta_spectrin 2230..2333 CDD:269975 18/110 (16%)
PH 2230..2333 CDD:278594 18/110 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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