DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and trioa

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_021323750.1 Gene:trioa / 557667 ZFINID:ZDB-GENE-060503-334 Length:3115 Species:Danio rerio


Alignment Length:2838 Identity:501/2838 - (17%)
Similarity:873/2838 - (30%) Gaps:1035/2838 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   358 DDMTRDAHSHDMHQHNVINNNTRRKTKSTEDMNVDTSTLKRMLKPMPSTESPVTSPEM------G 416
            :|.|.:|      :|.:.......:|.:.:|:..|....:||::...:.:..|....:      |
Zfish   213 EDFTGNA------RHLLARLEEMHETVTRKDLPQDLDGARRMIEEHAALKKRVIKAPVEEVDNEG 271

  Fly   417 RR---RYNYYNANAAQTLGHPPHMHQHGMAMGMGGGGGGGHHIMNNNTMGRASSQSSRFSGSRSS 478
            :|   |.....:.|.:|:..||     |...|.|........::...|.......|:|.:..:|.
Zfish   272 QRLLQRIQSSESYANRTVPVPP-----GQREGQGQPNADTQGLVPRITALLEKLHSTRQNLHQSW 331

  Fly   479 H--------------------------------------EIGRGYPP---------------RNL 490
            |                                      |||..:|.               .|:
Zfish   332 HIRKLQLDQCFQLRLFEQDAEKMFDWIMHNKGLFLAGYTEIGNNHPHAMELQTQHNHFAMNCMNV 396

  Fly   491 YLELERERSCIEGSPPSDNVMFDNQCYATTPSSSNGNSDQDQSYGQQ--QSSGQHPQQQQ----G 549
            |:.:.|..|.       .|.:.:...||:                ||  |.|||..|:.:    .
Zfish   397 YVNINRIMSV-------GNRLLEAGHYAS----------------QQIKQISGQLEQEWKAFAAA 438

  Fly   550 PPQRSSR-------HQHHHQQAPNVTP------TPGSPTSRLLLEYEMHLRNTLAKGMDA----- 596
            ..:||:.       ||...|...||..      ....|:....||..:|....|.:.:.|     
Zfish   439 LDERSALLEMSATFHQKCDQYMSNVDSWCKACGEVDLPSELQELEDAIHHHQGLYEHITAAYSEV 503

  Fly   597 ------ESYSLHTFEAL-LSQSMENLEFAESLPGSNQRSPYPLRRPNAKSSTLPLPPHRPLSTIR 654
                  ..||...|:.. |..|.:.....:.|    ||   ||...:|.|.|......:.::.:.
Zfish   504 QSRAAPNHYSERAFKRTHLEVSQDGKALLDKL----QR---PLTPGSADSLTASANYTKAVNHVL 561

  Fly   655 D-----KERDRDRDGYYSDRNELIRER--------ERERDRGYLSDHNSSFSNSRCASCIGES-- 704
            |     ....|..:..:..|...:.:|        :.::...::.:|..:|.:....  :|:|  
Zfish   562 DIIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTG--VGKSLH 624

  Fly   705 -ARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSG---------------------------- 740
             |||...||.|......:|..:........:|:..:|                            
Zfish   625 RARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQR 689

  Fly   741 ------------HKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEYLSDRES 793
                        |.:..|..|..|:::  |.|..|    |:|:|...:.|:              
Zfish   690 KVLLDMSVAFHTHVKELWTWLEELQKE--LLDDVY----AESVEAVQDLIK-------------- 734

  Fly   794 RYGIVQQASIEST------------DSRMCYLTSSEISDDDRMS-LTTAVSDEDDGESVMASPYK 845
            |:|..||.:::.|            ..|...::|::...:..:: :.:.:...|:.::.|...::
Zfish   735 RFGQQQQTTLQFTVNVIKEGEDLIQQLRDLAISSNKTPHNSSINHIESVLQQLDEAQAQMEELFQ 799

  Fly   846 AKATGTAASSFNCTGAVRKAGFLSVK--------------KW-------------------LLRK 877
            .:             .::...||.::              .|                   ..|.
Zfish   800 ER-------------KIKLELFLQLRIFERDAIDIISDLDSWNEELSQQMNEFDTEDLTLAEQRL 851

  Fly   878 KHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLII---VDGAIMQPIPEHPKRD 939
            :|..:.|.......:.|..:|..||.|.      ..|:|:...|:.   ||              
Zfish   852 QHHADKALTMNNLAFHVIHQGQELLQYV------NEVQASGVELLCDRDVD-------------- 896

  Fly   940 YIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAIESD 1004
                ::|...|...|....|.||:        ..|....||..:...|..||.|:.::...|.:.
Zfish   897 ----MATRVQDLLEFLHEKQQELD--------VAAEQHRRHLEQCVQLRHLQAEVKQVLGWIRNG 949

  Fly  1005 HKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLRCYM---ASLQSG--ELPNPK 1064
            ..:.:...:..|.:.:.|   |:|.:..|::..:|:.|  |..|:...   |.||:.  ::...:
Zfish   950 ESMLNAGLITASSLQEAE---QLQREHEQFQHAIEKTH--QSALQVQQKAEALLQANHYDMDMIR 1009

  Fly  1065 SLLTHVSRPTKNTLNKL--GVFTVSSFHAF------ICARSPSLLNNLLAGR----GATKRRP-- 1115
            ....:|:...:..:.|:  .:..|::..||      :|:...||........    ||.|..|  
Zfish  1010 DCAENVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNC 1074

  Fly  1116 ------PMLS----------------RSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRD 1158
                  ||:|                |.|:....:.|..||...|.....|..|:.....: |.:
Zfish  1075 ESDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYMHRNSVSMPGMLSHVKAPEQQVKNI-LNE 1138

  Fly  1159 AMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHR---------NDLIENYLHNHEFV 1214
            .:..|            |.:.||..::|||..:...|.|..|         :|..|.||..|  .
Zfish  1139 LLQRE------------NRVLHFWTMRKRRLDQCQQYVVFERSAKQALEWIHDTGEFYLSTH--T 1189

  Fly  1215 EVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMV 1279
            .....|.:..||    |::...|.:.|:  :..||...|........||..: |...||      
Zfish  1190 STGSSIHHTQEL----LKEHEDFHITAK--QTKERVKLLIQLADGFCDKGHS-HAAEIK------ 1241

  Fly  1280 INGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMS 1344
               ..|:.:|..|        :..|:.|...||.....:||..      ||              
Zfish  1242 ---KWVTAVDKRY--------RDFSLRMDKYRTSLEKALGISS------DS-------------- 1275

  Fly  1345 EEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSR 1409
                          |..||||.                                  |.:...::.
Zfish  1276 --------------NKASKDLQ----------------------------------LDIIPASAP 1292

  Fly  1410 TSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHL 1474
            .|..::.:......:|.|||                       |.:...::.||:.||:.||:.|
Zfish  1293 GSEVKLRDAAHELNEEKRKS-----------------------ARRKDFIMAELIQTEKAYVRDL 1334

  Fly  1475 NNLLEHYLEPM-----KRETFLSNAEINALFGNIHEIVTFQRQ-FLQNLEESLDLEPDFNKFEHC 1533
            ...::.||..|     :....:.|.| :.:|||:.::..|... ||:.||:...|..|       
Zfish  1335 RECMDTYLWEMTSGVEEIPPGIVNKE-HIIFGNMQDLYEFHHNIFLKELEKYEQLPED------- 1391

  Fly  1534 GQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQH--SST 1596
                     :|..|:.:.:.|::|.::|.:...:.:::..:.|.: ..|.      :|:|  :::
Zfish  1392 ---------VGHCFVTWADKFQMYVNYCKNKPDSTQLILEHAGGY-FDEI------QQRHRLANS 1440

  Fly  1597 LESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFD 1661
            :.||||||:|||.||.|||:::....:....|   :.:.|:.|..|.:..|:...:....|  ||
Zfish  1441 ISSYLIKPVQRITKYQLLLKELLTCCEEGKGE---IKDGLEVMLSVPKRANDAMHLSMLEG--FD 1500

  Fly  1662 HLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLR 1726
            ....            |.|:|:..   |...:.|....|:||.|.|  .|:|:.:::|..:.:..
Zfish  1501 ENIE------------SQGELILQ---EAFQVWDPKTLIRKGRERH--LFLFEMSLIFSKEVKDS 1548

  Fly  1727 QKKKLMGVSSKNATNEVEIIRY--------------------QVLIPVTEVQVRASSAKDMDSHF 1771
            ..:......||..|:|:.:..:                    ::::.:::.....|.|..:::..
Zfish  1549 NGRSKYIYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKLSQGCKHGSLASGIENKQ 1613

  Fly  1772 LWELIHLRSQLQRRS--------EKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGS 1828
            .| :.|:|..:|.|:        |.:::...|||..:.                     :.:...
Zfish  1614 DW-IKHIREVIQERTVHLKGALKEPIHIPKASTAKHKG---------------------RRYTPR 1656

  Fly  1829 SGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGS 1893
            .|  ....|||.||                          .:|...|.:.|.|...:|.|.|||.
Zfish  1657 DG--EDLDSQGDGS--------------------------SQPDTISLASRTSQNTLDSDKLSGG 1693

  Fly  1894 QEADDLPPSVGVVH-YASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPE--------------- 1942
            .|.      ..|:| :.:|:::...::      |.:|| :|.|.....|:               
Zfish  1694 CEL------TVVIHDFMAGNSNELTIR------RGQTV-EVLERLHDKPDWCLVRTTDRSPALEG 1745

  Fly  1943 ---------PHQQQQQQQQ-------------------QQQQLMQQGHAHAHPHPHPHPREPP-- 1977
                     .|.:...:.:                   .....:|.||... ....|.|:.|.  
Zfish  1746 LVPCAMLCIAHSRSSMEMEGIFNHKDALSVCSNDAIMPGSSATLQPGHVMG-SQSSPGPKRPGNT 1809

  Fly  1978 -----PPPIRQ-------------PHLHHHSSDIER-IDPGTKSEGEEDSQQGTIRPKATLGRTP 2023
                 ..|:|:             .|.|..|.|:.: .|.|::.:.::.:            .||
Zfish  1810 LRKWLTSPVRRLSSGKADGHVKKLAHKHKKSRDVRKSADAGSQKDSDDSA------------ATP 1862

  Fly  2024 NHLTLS--------TTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVH 2080
            ...||.        ::.|||..|:..                  |:..|         |.|.|..
Zfish  1863 QDETLEERVRNEGLSSGTLSKSSSSG------------------MQSCG---------EEEGEEG 1900

  Fly  2081 AAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIF 2145
            |..|.....::: ...||...||:|::|.||.     |:.||..::|                  
Zfish  1901 ADAVPLPPPMAI-QQHSLLQPDAQDDKTSSRL-----SVRPSSSETP------------------ 1941

  Fly  2146 ESEAERLAASQQVA----VVHQHPSDQARESGHKQRRDRDRNPT--------------ETDATAR 2192
             |.||.::|.:::.    .:...||..:.|.|...  ....||:              |...|..
Zfish  1942 -SAAELVSAIEELVKSKMALEDRPSTLSVEQGDSS--SPSFNPSDNSLLSSSSPIDEIEERKTGF 2003

  Fly  2193 FMDKH-----LSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDTGDHQQNDSSLSPEPQTIV 2252
            |..:|     |.:.|::.:.|.:..:..||..:||... |.|              :..:.:.:.
Zfish  2004 FKKRHYVLLELIETERDYVRDLSLVVEGYMARMREDGV-PDD--------------MKGKDKIVF 2053

  Fly  2253 ENTQQTVVVD-------------IESPSRPATESDSTGNTTGP----SERSGDETEEEATTSSLA 2300
            .|.||  :.|             :|.|.|           .||    .||            .|.
Zfish  2054 GNIQQ--IYDWHKDFFLGELEKCLEDPDR-----------LGPLFLKHER------------RLH 2093

  Fly  2301 SHIV----------VIDKKVDKIFKAKSPERPASTKVKGGRR----QIYISPDRCKSQGSSPVRI 2351
            .:||          ::.:.:|..|:        ..|.:.|.|    .:.|.|.:         ||
Zfish  2094 MYIVYCQNKPKSEHIVSEYIDTYFE--------DLKQRLGHRLQITDLLIKPVQ---------RI 2141

  Fly  2352 IKI-----------KSPRTSLSDQGKRLSV-CSSRDNSQDRLSAGRRTPSPRRSSEGGGILKHTT 2404
            :|.           |...|...:..|.:.| |.......|.::.||......:....|.:|...|
Zfish  2142 MKYQLLLKDFLKFSKKIGTDSIELEKAVEVMCIVPKRCNDMMNVGRLQGFDGKIVAQGRLLLQDT 2206

  Fly  2405 ----GPDPGILKPPSSPAKSKSPDRSCL-------------KKGGPSHVCSVETLSPRVSPRGSM 2452
                .|:.|:|        ::..:|...             ||.|.|....:...|.:|:..|..
Zfish  2207 FMVAEPEGGLL--------NRMKERRVFLFEQIVIFSEPLDKKRGFSMPGYLYKYSIKVNCLGLE 2263

  Fly  2453 DHLSPDR---GMTSSSCLRHSPRSSFDSHGESDHNLDVPHGSRKRSMSAHGSFETGTRPRAQETY 2514
            |.:..|.   .:||.:  .:|.:.:|..|                  |:|        |..::.:
Zfish  2264 DSVDGDPCKFALTSRT--SNSSKDAFILH------------------SSH--------PGVRQVW 2300

  Fly  2515 QYYPVYDNQTCSDHYVAAAPTGRYGGGTSSRSRLSKSLERSTSRDSTTTSSSYGHRAYGVSPDRN 2579
            ..                              ::|:.||...:..:..||.        :...||
Zfish  2301 ML------------------------------QISQILESQRNFLNALTSP--------IDYQRN 2327

  Fly  2580 YV----VFSSGPLRSQSAENTFS--------------SQPIYDPLPRHPPQPL--HQP---PMHH 2621
            :|    |..||.....|.....:              |:|...|.|...||||  |.|   |..|
Zfish  2328 HVEGPGVSGSGVQAGGSGGQMMAPGGGVGVPAGPGSRSRPSRIPQPSRLPQPLRHHSPALGPGAH 2392

  Fly  2622 QQQQQQQQQQQYMSYAP-EMGGYTGCQHDPQGGYQLSSSA-PEYTTCIDCLYQKRPSXHKSRVRQ 2684
            :.....:...  ||..| ..|....|..:|:...:|.:|. |:.|   |....:.|: ...|...
Zfish  2393 EHDGPDKLSG--MSPRPLSRGPSPSCTTEPEPKVKLPASPHPKQT---DSQQTESPAKEIPRATV 2452

  Fly  2685 SRTRKKTPR-GMVVVSAQPTATGGI---------GFVPEMGSS 2717
            :......|| |.|...|.|.||...         |  |:.|||
Zfish  2453 APLALVKPRPGTVSPMASPLATPAFKDSIPPCSPG--PKTGSS 2493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 25/160 (16%)
PH 873..974 CDD:278594 20/122 (16%)
TIAM1_RBD 1141..1219 CDD:176413 18/86 (21%)
PDZ_signaling 1221..1308 CDD:238492 17/86 (20%)
RhoGEF 1456..1647 CDD:238091 49/198 (25%)
PH2_Tiam1_2 1650..1823 CDD:269957 31/200 (16%)
PH 1693..1812 CDD:278594 24/146 (16%)
trioaXP_021323750.1 SEC14 61..199 CDD:214706
SPEC 212..447 CDD:238103 45/267 (17%)
SPEC 343..589 CDD:238103 47/275 (17%)
SPEC 590..806 CDD:238103 33/250 (13%)
SPEC 810..1037 CDD:238103 43/263 (16%)
SPEC 931..1160 CDD:238103 48/246 (20%)
SPEC 1166..1266 CDD:197544 27/125 (22%)
RhoGEF 1316..1488 CDD:238091 49/198 (25%)
PH1_Kalirin_Trio_like 1495..1627 CDD:270060 26/151 (17%)
SH3_Kalirin_1 1695..1754 CDD:212786 10/71 (14%)
SH3-RhoG_link 1752..2000 CDD:318750 53/314 (17%)
RhoGEF 2007..2180 CDD:238091 39/229 (17%)
PH2_Kalirin_Trio_p63RhoGEF 2185..2324 CDD:270061 31/212 (15%)
Atrophin-1 <2364..2523 CDD:331285 38/137 (28%)
SH3_Kalirin_2 2570..2628 CDD:212787
I-set 2702..2793 CDD:254352
PKc_like 2805..3067 CDD:328722
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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