DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and prex2

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_001923357.1 Gene:prex2 / 557288 ZFINID:ZDB-GENE-091113-37 Length:1600 Species:Danio rerio


Alignment Length:1269 Identity:253/1269 - (19%)
Similarity:451/1269 - (35%) Gaps:340/1269 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1452 DAEK---LRKVVM-ELVDTERTYVKHLN--NLLEHYLE---PMKRETFLSNAEINALFGNIHEIV 1507
            |.||   ||..|: ||:.|||.||..|.  ::|.|.|.   ..|.:..::...:..||.|:.||:
Zfish    16 DLEKQLRLRVCVLNELLKTERDYVGTLEFLSVLLHRLNQYAASKIDKNITEETVKVLFSNLEEIL 80

  Fly  1508 TFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLH 1572
            :..|.||..:||.  |:||.|.:..          :|..||::...|::|..:|.:|.|||::|.
Zfish    81 SVHRDFLNMVEEL--LQPDPNPYHE----------VGHCFLHFRGRFQIYDEYCGNHEKAQRLLL 133

  Fly  1573 PNEGNHALQEFL---AARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCE 1634
            .......::..|   .....::.....||.||:.|||||.||||:|:::...|..:.:::..:.|
Zfish   134 ELNKIRTVRTLLLNCMLLGGRKNTEVPLEGYLVAPIQRICKYPLILRELLKRTPKKHNDYSKVQE 198

  Fly  1635 ALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISD---- 1695
            :|:.|:.|...|||.:|..|:...:.:  ::.|.:                 |.|..||:|    
Zfish   199 SLQVMKAVCSSINEAKRQMEKLEVLEE--WQSHIE-----------------GWEGSNITDSCTE 244

  Fly  1696 -----FLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVE-IIRYQVLIPV 1754
                 .|.||..|.....:.|:|.:.:|: ||::.|:.|     :||.||.... :.|.::...|
Zfish   245 MLMQGILLKISAGNIQERIFFLFDNLLVY-CKKKNRRLK-----NSKAATEGPRYLFRGRINTEV 303

  Fly  1755 TEVQVRASSAKDMDS-----HFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRES 1814
            .||:.......|..|     :..|: ||     .....|.:|....|.:.:..:|:.   |::|.
Zfish   304 MEVENVDDGTADFHSSGNIVNNGWK-IH-----NTAKNKWFVCMAKTPEEKQEWLEA---ILKER 359

  Fly  1815 VRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQR 1879
            .|..::.:.....:...:|....:....|...|:  .::..|:::|..        ||...||: 
Zfish   360 ERRKTLRLGMEQDTWVMISEKGEKFYNLMSKQGH--LIKDRKRKLTTF--------PKCFLGSE- 413

  Fly  1880 HSAGNIDYDNLSGSQEADDLPPSV---GVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSP 1941
            ..:..:|....:..:|...|..::   |::|:.: ..|..:.:|..:|.|   ..|.|.      
Zfish   414 FVSWLMDIGETNNPEEGVHLGQALLENGIIHHVT-DKHQFKPEPVLYRFR---YDDGTY------ 468

  Fly  1942 EPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQP--HLHHHSSDI--ERIDPGTKS 2002
            .|....|....:..:|..:.|:..            .|.||..  ||..:.|.:  .::.....:
Zfish   469 HPRSDMQDVISKGVRLFCRLHSLF------------TPVIRDKDYHLRTYKSVVMANKLIDWLIA 521

  Fly  2003 EGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSS------------------ 2049
            :|:..|::..:    .||             :.:...|....:::.|                  
Zfish   522 QGDCRSREEAL----ILG-------------VELCDNGFMHHVLEKSEFKDEPLLFRFFADEEME 569

  Fly  2050 -----HPPASY-----QPVLMKD-LGKPS--------PDESELESESEVHAAQVAASFNLSLGSS 2095
                 |.|..:     :.|:.|. |.|||        .|.:.:.....|.....|....|.:|. 
Zfish   570 GSNTKHKPIKHDLKIVENVIAKSLLIKPSEGGYGFTLEDRNRVPIVKSVEKGSHAEMAGLEVGK- 633

  Fly  2096 GSLFASDARD-------NQTQSRTQSQIHSLHP-------SPRQSPRQSPRQSPKQDIEVIEIFE 2146
             .:||.:. |       .:.::..:...||..|       .||::.: .|..:.....::.....
Zfish   634 -KIFAING-DLVFLRPFQEVENFLKQCFHSRGPIRVLVSTKPRETVK-IPDSADGLGFQIRGFGP 695

  Fly  2147 SEAERLAASQQVAVVHQHPS---------DQARES-----GHKQRRDRDRNPTETDATARFMDKH 2197
            |....:......||...||.         :.::||     .|.....:.|.||:.|:.....:..
Zfish   696 SVVHAVGRGTVAAVAGLHPGQCIIKVNGINVSKESHASVIAHVTACRKYRRPTQQDSIKWVYNNS 760

  Fly  2198 LS---DLEQENLTDGTCD----IVAYMESLREKAFDPQDLAEDTGDHQQNDSSLSPEPQTIVENT 2255
            .|   |.::.|....|.|    ....:|.:.:| |:...:.:...||    .||:      |:|.
Zfish   761 ESAQEDHQRSNQKPTTGDNGDVFECKVEEVMDK-FNTIAIIDGKKDH----VSLT------VDNV 814

  Fly  2256 --QQTVVVDIESPS-----------RPATESDSTGNTTGPSERSGDETEEEATTSSLASHIVVID 2307
              :..|:.:.:|.:           .|......|........|:.::..:  |.|.|:|...:|.
Zfish   815 YLEYGVMYEYDSTAGMKCHVLEKMVEPKGFFSLTAKILEALARNDEQLVQ--TCSRLSSSAELIP 877

  Fly  2308 KKVDKIFKAKSPER-----------------------PASTKVKGGRRQIYISPDRCKSQGSSPV 2349
            :.:...|.|...||                       |...:.|.....:: |.|.|.:  :..:
Zfish   878 EDLQTRFTAMCGERLEHINRRITNYRKFSRVLKNRAWPTFKQAKSKVSPLH-SSDFCPT--NCHI 939

  Fly  2350 RIIKIKSPRTSLS---------DQGKRLSVCSSRDNSQDRLS---------AGRRTPSPRRSS-- 2394
            .::::..|:|:.|         |..|......||::.|.:|:         .....||....|  
Zfish   940 NVMEVSYPKTTTSLGSAFGVQLDNRKNTLEKGSRNSEQGKLNPMVYVQHSITSMAAPSGHSLSRA 1004

  Fly  2395 EGGGI------------------------------------------LKHTTGPDPGILKPPSS- 2416
            ||.|:                                          :.|.||.:.   ||..| 
Zfish  1005 EGHGLRFLLREDDLLILDAYHKLLTKLTTVVKEMECYAAQIHDLLSSITHPTGSEG---KPTESY 1066

  Fly  2417 -PAKSKSPDRS-------CLKKGGPSHVCS-VETLSPRVS---PRGSMDHLSPDRGMTSSSCLRH 2469
             .|:|:| |||       |....|.....| .:|:|.|.|   ...:.:.::....:.||.|..:
Zfish  1067 ISAESES-DRSERNGKKVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSIASFTSICSSHCSSY 1130

  Fly  2470 SPRSSFDSHGESDHNLDVPHGSRKRSMSAHGSFE 2503
            ......||..|...::.:.|..:|:   .||..|
Zfish  1131 VHSDEMDSGDEMPTSVWISHDKQKK---LHGFLE 1161

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 60/199 (30%)
PH2_Tiam1_2 1650..1823 CDD:269957 39/187 (21%)
PH 1693..1812 CDD:278594 31/133 (23%)
prex2XP_001923357.1 RhoGEF 27..212 CDD:279015 59/196 (30%)
PH_Collybistin_ASEF 217..363 CDD:269931 38/179 (21%)
PH 247..355 CDD:278594 28/122 (23%)
DEP 381..461 CDD:295306 15/91 (16%)
DEP_2_P-Rex 473..565 CDD:239887 15/120 (13%)
PDZ_signaling 594..669 CDD:238492 15/77 (19%)
PDZ_signaling 676..743 CDD:238492 9/67 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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