DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and fgd6

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_001093450.1	Gene:	fgd6 / 556459	ZFINID:	ZDB-GENE-041210-200	Length:	1315	Species:	Danio rerio

Alignment Length:	1305	Identity:	235/1305 - (18%)
Similarity:	432/1305 - (33%)	Gaps:	438/1305 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   739 SGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLEQRAEFIRQDSLRSEY-----------LSDRE 792
            :.|||..    |::.....|..:..|..:|          |||..::::           ||...
Zfish    37 TAHKRGK----PAVAPKPCLLKAPQKPVQA----------RQDHCKNQHPPVSKNGGPALLSSNL 87

  Fly   793 SRYGIVQQASIESTDSRMCYLTSSEISDDDRMS----LTTAVS-------------DEDDGESVM 840
            |.|       |....:::|:|.:::.:|...:|    |||.|.             ..|..|...
Zfish    88 SHY-------IIPPCNKVCHLANNKSNDSKEISREATLTTEVGVFKEGDSPKEHLFSNDTWEHTA 145

  Fly   841 ASPYKAKATGTAASSFNCTGAVRKAGFLSVKK-----WLLRKKH-----QIELARKRGWKGYWVC 895
            .|.:..:...|.::..: |.|..:....||:|     .:|...|     ..|..::|..:
Zfish   146 RSEHVQEQVPTDSTQMS-TEAQDETNSPSVEKDQTSTQVLTSDHIPRHCPTEPLQERSSE----- 204

  Fly   896 LKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIP-EHPKRDYIFCL--------------- 944
            :|.|..:|..|.| :...|.|.|.          :|:| .||:|.....|
Zfish   205 VKETGNVFSSCTS-DSVGVPAPPS----------KPLPVPHPRRPRRALLRQNVVEIAPSDTQAD 258

  Fly   945 ------STAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFR--LEKAI 1001
                  ..|..|. |.:.|......:..:::.:||..               :|:|..  .:.:.
Zfish   259 IPTETPENAQSDG-LQETPKNTTCHSHTSTLQNACCP---------------KEDIENTDTDSST 307

  Fly  1002 ESD--HKLKHMAELQ-QSVVTDQETRHQI---------------------------QTQILQWEE 1036
            :||  ||:......| :.:.:|.::.|..                           |..:.|..:
Zfish   308 KSDPLHKVDSFYNAQTEDMPSDLDSTHYSVPTNGATLASMDTAVEDGSQPPAPPPRQKSLPQMVD 372

  Fly  1037 NLER---------LHCE-------------------------------------QFRLRC----- 1050
            :|.:         |||:                                     |.:|.|
Zfish   373 SLCKASTSVDNLLLHCQSDLQEVTSNDEDAESDDEDDGAYGDFARYPITRSLPKQIKLSCGSQVI 437

  Fly  1051 -----YMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGA 1110
                 |:    .|:..:||.:   ..:|.:|:|           .|.:..|.
Zfish   438 AITKPYI----DGDEKSPKVM---PKKPQRNSL-----------PASVALRK------------- 471

  Fly  1111 TKRRPPMLSRSNS---GSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACAR 1172
             :..||.|..||.   |      ::.:..:.:.:::||:|             |:..|..:...|
Zfish   472 -QGTPPPLPNSNPPVFG------ELPAPPQEKPSWRVALP-------------SIPLFSRNQPTR 516

  Fly  1173 RNLNPMEHFVR---VKKR------RDME--DHNYFVPH---RNDLIENYLHNHEFVEVCMKILYQ 1223
            .|..|....|.   ||:|      .|::  |:......   |:|.....|.....:.||.::|
Zfish   517 SNSQPQAGVVGSVFVKQRAKSFSSADLQRVDNGSEASEQLARSDQTRRSLRKLLELRVCARLL-- 579

  Fly  1224 VELQRTTLEQMWGFSVEAELIENAERQDELCCYV-SRVEDKSVAMHNGIIKGDEIMVINGAIVSD 1287
                             .:|:.:.:..|  |... |..|:......|.:..||: ....|...:|
Zfish   580 -----------------PKLLRSGQSLD--CTRTDSEYEEHKAVPANQVTSGDD-EEAQGDSEAD 624

  Fly  1288 LDMMYLESVLQEEQSLSM---MMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSEEMIT 1349
            ..:.|....|.||....|   .:.|::....|:..:..                  |.|:.|.:.
Zfish   625 CGVEYENVPLYEEIPEYMNLPWVYSNQDADTDVYEVQE------------------PSMTVEFVN 671

  Fly  1350 GLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVG--------GVGGVVVGGLGVAKP 1406
            ..:.....|      |...|. |.||..      ..|:||||        ...|.|.|.:.:. |
Zfish   672 AFLTFISHW------LVCDEL-SVPAKQ------RCAELAVGFQMHRTLNQACGRVFGNVSML-P 722

  Fly  1407 TSRTSSFEI-ENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVV---MELVDTE 1467
            |:...|.:: |:.|.:.|::...|.      ||......:..::..:..|..|||   ||::.:|
Zfish   723 TNIYMSADLSEDGLSSNEEDGDSSD------SSKEDMRHSKDKEEVERAKRNKVVHIAMEIMSSE 781

  Fly  1468 RTYVKHLNNLLEHYLEPMKRET------FLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPD 1526
            :.:|..|..|...:.:.:.:.|      .:....:|.:...:.::....:..|:.|||.:....|
Zfish   782 KVFVDVLKLLHIDFRDAVAKATRASGKPLVEEKVLNQILYYLPQLYELNKDLLKELEERVAHWSD 846

  Fly  1527 FNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNP-- 1589
            ..:             :...|:....:.|:||::.....:          |.||.:....:||
Zfish   847 HQR-------------LADIFVQKGPYLKMYSTYIREFDR----------NVALLDEQCRKNPPF 888

  Fly  1590 ----KQQHSS------TLESYLIKPIQRILKYPLLL-QQMRNLTDTRADEHVHLCEALKGMEKVA 1643
                :|..:|      .|:.||:||:|||.:|.||| ..::||.:..:| :.....||..:::||
Zfish   889 SSVVRQFETSPRCASLALKHYLLKPVQRIPQYQLLLTDYLKNLPEDSSD-YKDTQTALSVVKEVA 952

  Fly  1644 EHINEMQRIHEEYGAIFDHLFR-QHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELH 1707
            .|.|::.:    .|..|..|.: |:..:....| :.||.:....|.        |.|:.:.:...
Zfish   953 NHANDIMK----QGDNFQKLMQVQYSLNGHHEI-VQPGRVFLKEGT--------LMKLSRKVMQP 1004

  Fly  1708 AMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQV--LIPVTEVQVRASSAKDMDSH 1770
            .|.|:|...:::                    |..|:..:|:|  ::.:..::|...|.:...:.
Zfish  1005 RMFFLFNDILLY--------------------TTPVQSGQYKVNSMLSLAGMKVSKPSQEAYQNE 1049

  Fly  1771 FLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGH 1835
            ...|.:          |:.::||.::|..|:.:|:.|...|.:..|.   .:..|...|..:.|.
Zfish  1050 LNIESV----------ERSFILSANSATERDEWLEAIATAIDDYTRK---KISFFSSRSQELEGI 1101

  Fly  1836 SSQGM 1840
            |..|:
Zfish  1102 SDDGL 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	28/156 (18%)
		PH	873..974	CDD:278594	23/127 (18%)
		TIAM1_RBD	1141..1219	CDD:176413	19/91 (21%)
		PDZ_signaling	1221..1308	CDD:238492	16/90 (18%)
		RhoGEF	1456..1647	CDD:238091	47/212 (22%)
		PH2_Tiam1_2	1650..1823	CDD:269957	29/175 (17%)
		PH	1693..1812	CDD:278594	19/120 (16%)
fgd6	NP_001093450.1	DUF4775	<93..327	CDD:292620	48/266 (18%)
		RhoGEF	773..957	CDD:279015	44/207 (21%)
		PH-like	975..1097	CDD:302622	27/163 (17%)
		PH	990..1080	CDD:278594	20/127 (16%)
		FYVE_FGD6	1113..1173	CDD:277282
		PH	1221..1313	CDD:278594
		PH2_FGD5_FGD6	1221..1309	CDD:270057
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910