DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and vav2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_021324720.1	Gene:	vav2 / 556413	ZFINID:	ZDB-GENE-091204-420	Length:	891	Species:	Danio rerio

Alignment Length:	904	Identity:	171/904 - (18%)
Similarity:	293/904 - (32%)	Gaps:	317/904 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1416 ENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEH 1480
            |:::|...::...|.|.....|.:   .......:|:.:|....::|:.:||..|.|.|.::.::
Zfish   174 EDIIKVEVRQPMVSEPPYGRRSLI---RYMQKMGMTEDDKRNCCLVEIQETEAKYYKTLEDIEKN 235

  Fly  1481 YLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGS 1545
            |:.|:|:  .|:..|:.|:|.|:.:|:......|:.::  |.:....|             .:|.
Zfish   236 YMIPLKQ--VLTPQEMEAIFVNLEDIIRVHFALLRAID--LTMVSGGN-------------GLGK 283

  Fly  1546 AFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARN-----------PKQQHSSTLES 1599
            .||.:.....:|..:|:....|||         .|.|.:|.|.           ..|:....|:.
Zfish   284 IFLDFKERLLIYGQYCSHMENAQK---------TLDELIATREDVKCKVEECTMKVQEGKFKLQD 339

  Fly  1600 YLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHE------EYGA 1658
            .|:.|:||:|||.|||:::.:.:..| .|...|.|||:.|:.:|.:|||::|.:|      |:.:
Zfish   340 LLVVPMQRVLKYHLLLKELVSHSMDR-PERQQLKEALEAMQDLAMYINEVKRDNETLKKISEFQS 403

  Fly  1659 IFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKE 1723
            ..::|..:.::..:..||   |:         |.:...:.:.|:...:    |:| ..||.:|
Zfish   404 SIENLQVKLEEYGRPKID---GE---------LKVCSIVNRTKQDRYI----FLF-DKVVIVC-- 449

  Fly  1724 RLRQKKKLMGVSSKNATNEVEIIRYQVL-IPVTEVQVRASSAKDMDSHFLWE----LIHLRSQLQ 1783
                |:|......|..   :|:..|::. .|:....::.||.|      :|.    ||||:.:
Zfish   450 ----KRKGYNYELKEV---IELHLYKMSDDPMNNRDMKKSSGK------MWSYGFYLIHLQGK-- 499

  Fly  1784 RRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGN 1848
                         ..|: .|.|| ....|:.:....:.|.|......:.:.|:.|
Zfish   500 -------------QGFQ-FFCKT-EDTKRKWMEQFEMAMSNIKPERATANQHNFQ---------- 539

  Fly  1849 SQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNI---DYDNLSGSQEADDLPPSVGVVHYAS 1910
                            .||..|.......:....|..   .|.:|.|:
Zfish   540 ----------------MHTFEKNTNCRACKMLLRGIFYQGYYCSLCGT----------------- 571

  Fly  1911 GHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPRE 1975
                          |..|...::  ||.....||..:....|...:::...:.|..|.|
Zfish   572 --------------GAHKECLEI--ITICKISPHDSEPGLPQSGPKMVAIRNYHGTPAP------ 614

  Fly  1976 PPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTG 2040
                                  ||
Zfish   615 ----------------------PG----------------------------------------- 616

  Fly  2041 SQARLIQSSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARD 2105
                     ..|..:|...:.:|.|..||.|..|                     |.|.
Zfish   617 ---------KIPLCFQTGEVIELLKGDPDTSWWE---------------------GKLI------ 645

  Fly  2106 NQTQSR----TQSQIHSLHPSPRQ--SPRQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQH 2164
             |||..    :.|....|.|.|.|  |.|||.|::   |..|...|....||..|...:
Zfish   646 -QTQKTGYFPSSSVKPCLDPKPFQAFSNRQSSRET---DYYVYPWFAGNMERQQADNLL------ 700

  Fly  2165 PSDQARESGHKQRRDRDRNPTETDATARFMD--KHLSDLEQEN---LTDGTCDIVAYMESLREKA 2224
               ::..||....|:|.........:.:|.|  ||:..:|::|   :|:     ....|||.|
Zfish   701 ---KSHSSGTYLIRERTAEAERFAISIKFNDEVKHIKVIEKDNWIHITE-----AKKFESLLE-- 755

  Fly  2225 FDPQDLAEDTGDHQQNDSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTTGPS 2283
                 |.|....|...:|.      .:::.|       :..|.:....|.|..||..|:
Zfish   756 -----LVEYYQSHSLKESF------KLLDTT-------LRYPYKSRERSSSRTNTRSPA 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	50/201 (25%)
		PH2_Tiam1_2	1650..1823	CDD:269957	33/183 (18%)
		PH	1693..1812	CDD:278594	24/123 (20%)
vav2	XP_021324720.1	CAMSAP_CH	18..103	CDD:314792
		RhoGEF	211..386	CDD:238091	50/201 (25%)
		PH_Vav	401..528	CDD:269930	32/175 (18%)
		C1	536..579	CDD:237996	11/99 (11%)
		SH3	601..660	CDD:327375	19/164 (12%)
		SH2_Vav2	680..782	CDD:198269	27/135 (20%)
		SH3_VAV2_2	832..889	CDD:212910
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940