DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and arhgef7a

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_021334338.1	Gene:	arhgef7a / 553493	ZFINID:	ZDB-GENE-060322-11	Length:	864	Species:	Danio rerio

Alignment Length:	881	Identity:	168/881 - (19%)
Similarity:	265/881 - (30%)	Gaps:	356/881 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1428 KSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLS 1492
            ||.|.|..|:|:|.|            ....|:..:::||..|.:.|.|||..||.|::....||
Zfish   240 KSPPKGFDTASISKT------------YYNLVLQNILETETEYSRELQNLLTSYLRPLQMTERLS 292

  Fly  1493 NAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFK-L 1556
            .|:::.:.||:.||.|||:..:|:||       |..|.....|      .:|..||..:...: |
Zfish   293 PADVSVILGNLEEISTFQQTLVQSLE-------DLTKLPELQQ------KVGGFFLNLMPQMRSL 344

  Fly  1557 YSSFCASHSKAQKVL--HPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMR 1619
            ..|:|::|.....||  |..|    |.||:.||........||.|.|.||..|:.:||.||:
Zfish   345 NVSYCSNHPSTVNVLTVHSEE----LGEFMEARGASVPGILTLTSGLSKPFMRLDRYPTLLK--- 402

  Fly  1620 NLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLY 1684
                                        |::| |.|.|    |..|...:.|.
Zfish   403 ----------------------------ELER-HMEEG----HPDRTEIQKCM------------ 422

  Fly  1685 YGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQ 1749
               ..:.|:|             |.|            :.:|::|:|
Zfish   423 ---TAFKNLS-------------AQC------------QEVRKRKEL------------------ 441

  Fly  1750 VLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRES 1814
                  |:|:.|.:.:      |||                          ...:||:..::..|
Zfish   442 ------ELQILAETIR------LWE--------------------------GEDIKTLGSVLYMS 468

  Fly  1815 ---VRNMSIPMKN------------FGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHG 1864
               |:|.....||            ...:|..:||...||             :.|...:|:.
Zfish   469 QAMVQNHGCEEKNERYLLLFPHVLLILSASPRMSGFIYQG-------------KLPLSGMTVT-- 518

  Fly  1865 SHTLGKPKKKSGSQRHSAGNIDYDNLSGSQ---------EADDLPPSVGVVHYASGHT--HGQQM 1918
                  |.:...|.:      |...||||.         ...||...:..::..:.||  ....|
Zfish   519 ------PLEDCESHK------DAFELSGSMFERLQVICYNKQDLHDWLEHLNRQTKHTTMAAPSM 571

  Fly  1919 QPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPH----------P 1973
            :|             ..:.|.:...|.....:..:.:.|......|..|||..|          |
Zfish   572 KP-------------LTVPCHTLPSHPLTPSRHGESRGLTVAPAYHTLPHPSSHGTPHSTMMWGP 623

  Fly  1974 REP-------------PPPPIR-------QPHLHHHSSDIERIDPGTKSEG-------------- 2004
            .||             |.||:|       :..|......::::.|..|.|.
Zfish   624 LEPPKTQKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTV 688

  Fly  2005 --EEDSQ--------QGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVL 2059
              |||:|        ..:.:.:.||..|.....|.....|...|..|..|....|.|.|:
Zfish   689 ALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLDQSSADSLGRRSSISRPEAT----- 748

  Fly  2060 MKDLGKPSPDESELESESEVHAAQVAASFNLSL-------GSSGSLFASDARDNQTQSRTQSQIH 2117
                       |:|..:|:..:...|.|:.:..       ||...:...|.:.:..:.::..|
Zfish   749 -----------SDLSEDSDYDSIWTAHSYRMGSVTRQWKDGSPALIVPGDEKFSVDELKSNGQ-- 800

  Fly  2118 SLHPSPRQSPRQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHKQRRDRDR 2182
                         .....|..::|:.....|.:.|                      ||...:.:
Zfish   801 -------------TLLEEKSLVDVVYALRDEVQEL----------------------KQDYKKMK 830

  Fly  2183 NPTETDATARFMDKHLSDLEQ------ENLTDGTCD 2212
            ...|.:..||      .|||:      :|:.|.:.|
Zfish   831 KSLEEEQRAR------KDLERIVKKMLKNMNDPSWD 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	54/193 (28%)
		PH2_Tiam1_2	1650..1823	CDD:269957	25/175 (14%)
		PH	1693..1812	CDD:278594	14/118 (12%)
arhgef7a	XP_021334338.1	CH	21..106	CDD:214479
		RhoGEF67_u1	116..168	CDD:318756
		SH3_alphaPIX	170..226	CDD:212993
		RhoGEF	256..433	CDD:238091	66/269 (25%)
		PH_Cool_Pix	464..562	CDD:269932	21/124 (17%)
		RhoGEF67_u2	621..715	CDD:318755	17/93 (18%)
		betaPIX_CC	775..861	CDD:318676	19/129 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910