DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and sptbn1

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_009304586.2 Gene:sptbn1 / 553451 ZFINID:ZDB-GENE-031006-3 Length:2363 Species:Danio rerio


Alignment Length:2652 Identity:457/2652 - (17%)
Similarity:826/2652 - (31%) Gaps:865/2652 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   375 INNNTRRKTKSTEDMNVDT---STLKRMLKPMPSTESPVTSPEMGRRRYN-YYNANAAQTLGHPP 435
            :|::..|.:....|:.:|.   ..|.::|:.:.....|  .|..||.|.: ..|.:.|.......
Zfish    76 VNSHLARVSCRITDLYMDLRDGRMLIKLLEVLSGERLP--KPTKGRMRIHCLENVDKALQFLKEQ 138

  Fly   436 HMHQHGMAMGMGGGGGGGHHIMNNN---TMGRASSQSSRF------------SGSRSSHEI---- 481
            .:|...|         |.|.|::.|   |:|...:...||            ...||:.:.    
Zfish   139 RVHLENM---------GSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKRSAKDALLLW 194

  Fly   482 ----GRGYPPRNLYLELERERSCIEGSPPSDNVMFDNQCYATTP--------SSSNGNSDQDQSY 534
                ..|||..|::......|         |.:.|:...:...|        ..||.:.:...::
Zfish   195 CQMKTAGYPNVNIHNFTTSWR---------DGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAF 250

  Fly   535 GQQQSSGQH--------PQ--QQQGPPQRS-----SRHQHHHQQAPNVTPTPGSPTSRLLLEYEM 584
            ...:   ||        |:  ....|.::|     ..:.|:.           |....|.:|.: 
Zfish   251 NLAE---QHLGLTKLLDPEDISVDHPDEKSVITYVVTYYHYF-----------SKMKALKVEGK- 300

  Fly   585 HLRNTLAKGMDAESYSLHTFEALLSQSME----------NLEFAESLPGSNQRSPYPLRRPNAKS 639
            .:...|...::.|. .:..:|:|.|..:|          |.:||.||.|..|:    |:..|. .
Zfish   301 RIGKVLDNAIETEK-MIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQ----LQAFNT-Y 359

  Fly   640 STLPLPPHRP--------LSTIRDKERDRDRDGYYSDRNELIRERERERDRGYLSDHNSSFSNSR 696
            .|:..||...        |.||:.|.|..::..|.....:||.:..:..:|...::|....:.. 
Zfish   360 RTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR- 423

  Fly   697 CASCIGESARAQWFRHSD-------GWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQ 754
             ...|.:....|..|..|       .|.|.:..:.|....|...|.:..:..|..      ::..
Zfish   424 -TELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLQAVEAATKKHE------AIET 481

  Fly   755 DSSLNDSGYKSARADSLEQRAE--------FIRQDSLRS--EYLSD--RESRYGIVQQASIESTD 807
            |.:..:...::..|.:.|...|        ..|:|::..  |||.:  :..|..:....|::...
Zfish   482 DIAAYEERVQAVVAVARELETENYHDIKRITARKDNVLRLWEYLLELLKARRQRLEMNLSLQRVF 546

  Fly   808 SRMCYLTSSEISDDDRMSLTT-----------------AVSDEDDGESVMASPYKAKATGTAASS 855
            ..|.|:  .:..|:.:|.|.:                 |:.:.|.|  :.|.  :.||....|..
Zfish   547 QEMLYI--MDWMDEMKMLLLSQDYGKHLLGVEDLLQKHALVEADIG--IQAD--RVKAVNNNAQR 605

  Fly   856 FNCTGAVRKAGFLSVKKWLLR-------------------KKHQIELARKRGWKGYWVCLKGTTL 901
            |    ||.:.|:......::|                   ::.::|.:| |.||.:|        
Zfish   606 F----AVDEEGYKPCDPQVIRDRVAHMEFCYQELTQLAAERRARLEESR-RLWKFFW-------- 657

  Fly   902 LFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQVELENWV 966
                         |.|                                           |.|.|:
Zfish   658 -------------EMA-------------------------------------------EEEGWI 666

  Fly   967 NSIHSACAAAFARHRGK--TGTLHLL-QEEIFRLEKAIESDHKLKHMAELQQSVVT-----DQET 1023
            .......::...   ||  ||.:.|| |......|.:..|.| |:|.....|::..     :.:.
Zfish   667 REKEQILSSDDC---GKDLTGAVRLLSQHRALEDEMSGRSGH-LQHTVREGQAMADAGHFGEAKI 727

  Fly  1024 RHQIQTQILQWEENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRPTKN-----TLNKLGV 1083
            |.:|.....||.. ||:|           ||::...|....||  |..:...:     ||:.|.:
Zfish   728 RERIADVQAQWAA-LEQL-----------ASVRKTRLEEACSL--HQFQADADDVDTWTLDALRI 778

  Fly  1084 FTVSSFHAFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPD 1148
            .:.:.......:....:..:..|.......||.:.:......:....|.||.:..|   ::|..:
Zfish   779 VSTADVGHDEFSTQALVKKHKDASTEVASYRPVIDALHEQAQTLPPEQANSANVSE---RLAGIE 840

  Fly  1149 NAYSTV---------YLRDAMSVEEFL--ASAC------ARRNLNPMEHFVRVKKRRDMEDHNYF 1196
            ..|..|         .|:||:::.:..  |.||      ..:.||.||   ..:|..|:|    .
Zfish   841 ERYKEVSELTRLRKQALQDALALYKMFSEADACELWIDEKEQWLNSME---IPEKLEDLE----V 898

  Fly  1197 VPHRNDLIENYLHNHEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSR-- 1259
            :.||.:.:|..::|.     ..::....::.|..:..  |...|.::   ..:||:|....|:  
Zfish   899 IQHRFESLEPEMNNQ-----ASRVAVVNQIARQLIHS--GHPSEKDI---KAQQDKLNTRWSQFR 953

  Fly  1260 --VEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMR 1322
              |:.|..::::.:          |.....||....:|.::|:   :.::.|::....||.|:|.
Zfish   954 DLVDQKKESLNSAL----------GVQNYHLDCNETKSWIREK---TKVIESTQELGNDLTGVMA 1005

  Fly  1323 VTDDMIDSLVCPPPPTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQ 1387
            :                     :..:||:          .:||                ||:.|:
Zfish  1006 L---------------------QRKLTGM----------ERDL----------------AAIEAK 1023

  Fly  1388 LAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTG------SVTSSVSTTALTP 1446
            |  |.:.|                  |.:.|  ..|...:..:.||      :|...:..|..|.
Zfish  1024 L--GDLRG------------------EADRL--AGEHPDQAKAITGRLAEITAVWEEMKETLRTR 1066

  Fly  1447 SRQLTDAEKLRKVVMELVD-----------------------TERTYVKH------LNNLLEHYL 1482
            ...|.:|.||::.:.||.|                       .|:...:|      :||..|.|.
Zfish  1067 EESLGEASKLQQFLRELDDFQSWLSRTQTAIASEDMPNTLAEAEKLLAQHEGIKNEINNYEEDYQ 1131

  Fly  1483 EPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAF 1547
            :.......::..:.:|.:       .|.||.||.|:..      :|:.....:.|..|.:...|:
Zfish  1132 KMRDMGEMVTQDQTDAQY-------MFLRQRLQALDTG------WNELHKMWENRQNLLSQSHAY 1183

  Fly  1548 LYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYP 1612
            ..::...|...:|.   :..:.||...|....|:...||...::...:|:::...| |..:::..
Zfish  1184 QIFLRDTKQAEAFL---NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEDK-INGVVEAG 1244

  Fly  1613 LLLQQMRNLTDTRADEH---------------VHLCEALKGMEKVAEHINEMQR----IHEE--- 1655
            ..|....|:...|..|.               |.|...||....:.:.:.:.|.    |:|:   
Zfish  1245 RRLASDGNINADRIQERAASIDDRHKKNREAAVELLMRLKDNRDLQKFLQDCQELSLWINEKMLT 1309

  Fly  1656 -YGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKI-KKGLELHAMCFVFKSAVV 1718
             ....:|.....|.|..|....::.    .....|||:      || |:|.:|.:.    |....
Zfish  1310 AQDMSYDEARNLHSKWLKHQAFMAE----LQSNKEWLD------KIEKEGKQLVSE----KPETE 1360

  Fly  1719 FLCKERLRQKKKLMGVSSKNATNEVEI---IRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRS 1780
            .:.||:|...:|:.        .|:|.   .:.|.|....:.::...|..|:|.   | |:.|..
Zfish  1361 AVVKEKLAALQKMW--------TELETTTQTKAQCLFDANKAELFTQSCADLDK---W-LVGLEG 1413

  Fly  1781 QLQRRS------------EKVYVLSNSTADFRNAFLKTI--------------------RQIIRE 1813
            |:|...            :|..:|.|. .:.|...::.:                    |:::.:
Zfish  1414 QIQSDDYGKDLTSVNILLKKQQMLENQ-VEVRQREVEELQSQAHVLRQEGKDTDEVDGRRKVVEQ 1477

  Fly  1814 SVRNMSIPM---KNFGGSSGSVSGHS----------SQGM---GSMGYPGNSQTLERPKQQITIV 1862
            ..:.:..|:   |||..:|..:...:          .:.|   .|..:..|.||::      .::
Zfish  1478 KFQELLDPLLKRKNFLMASREIHQFNRDVEDEILWVEERMPLATSTDHGNNLQTVQ------LLI 1536

  Fly  1863 HGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQ-EADDL-PPSVGVVHYASGHTHGQQMQPAGFRG 1925
            ..:.||.|                  .:.|.| ..||: ..|..::...|.:..|.:.:.:..:|
Zfish  1537 KKNQTLQK------------------EIQGHQPRCDDIFERSQSILKADSPNVEGIRTRLSDLQG 1583

  Fly  1926 RSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHS 1990
            ....:...||      :.|.:.::..:.||.......|.|.              :.:..|:..|
Zfish  1584 LWSLIMQETE------KRHSRLEEAHKAQQYYFDAAEAEAW--------------MSEQELYMMS 1628

  Fly  1991 SDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTL--------STTSTLSVGSTGSQARLIQ 2047
            .:        |::.|:.|          :.....|..|        .|...||..|.|    |:.
Zfish  1629 EE--------KAKDEQSS----------VAMLKKHQILEQAVEDYAETVHQLSKTSRG----LVA 1671

  Fly  2048 SSHPPAS------------YQPVLMKDLGKP--------------SPDESELE---SESEVHAAQ 2083
            ::||.:.            |..  :|||.:.              :.:..:||   :|.||    
Zfish  1672 ANHPESERIGMRQSQVDKLYAG--LKDLSEERRGKLEERFRLFQLNREVDDLEQWIAEREV---- 1730

  Fly  2084 VAASFNLS-----LGSSGSLFASDARD--NQTQSRTQSQIHSLHPSPRQSPRQSPRQSPKQD--- 2138
            ||.|..|.     :......|...|||  |..|.|..................:...:..:|   
Zfish  1731 VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDGVNRMADELINAGHADAATVAEWKDGLN 1795

  Fly  2139 ---IEVIEIFESEAERLAASQQVAVVHQHPSDQARESG-----HK---QRRDRDRNPTET----- 2187
               .:::|:.::..:.||||.:   :|:...|.....|     ||   :...||:|..||     
Zfish  1796 EAWADLLELIDTRTQILAASYE---LHKFYHDAKEILGRILDKHKKLPEELGRDQNTVETLQRMH 1857

  Fly  2188 ------------------DATARFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDT 2234
                              |...|....:..| :.:::.....:::....||.|.....:....||
Zfish  1858 TTFEHDIQALGTQVRQLQDDAVRLQSAYAGD-KADDIQRREGEVLEAWRSLLEACEGRRARLLDT 1921

  Fly  2235 GDH------------------QQNDSSLSPEPQTIVE---NTQQTVVVDIESPSRPATESDSTGN 2278
            ||.                  :..::...|...:.||   |..|.:..:|::.:...|.....|.
Zfish  1922 GDKFRFFSMVRDLMLWMEDVIRLIETQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTACIELGK 1986

  Fly  2279 TTGPSERSGDETEEEATTSSLASHIVVIDKKVDK------IFKAKSPERPASTK---VKGGRRQI 2334
            :....:....|..:|...........:|||..|:      |.:.....|.|...   :.|  ::.
Zfish  1987 SLLARKHYASEEIKEKLLQLTDKRKDMIDKWEDRWEWLRLILEVHQFSRDAGVAEAWLLG--QEP 2049

  Fly  2335 YISPDRCKSQGSSPVRIIKIKSPRTSLSDQGKRLSVCSSRDNSQDRLSA---------------G 2384
            |:|   .:..|.|...:.|:.....:..   |..:....|.::.:||:.               .
Zfish  2050 YLS---SRELGQSVDEVEKLIKRHEAFE---KSAATWEERFSALERLTTLELLEVRRLQEEEERR 2108

  Fly  2385 RRTPSP---------RRSSEG-----GGILKHTTGPDPGILKPPSSPAK--SKSPDRSCLKKGGP 2433
            |:.|||         .:..||     .|:......|..|:....:..|:  ||.|          
Zfish  2109 RKPPSPDPVQAQDGETQQREGEQIAQNGLPSDQDSPRDGVDGEMNGVAERSSKEP---------- 2163

  Fly  2434 SHVCSVETLSPRVSP------RGSMDHLSPDRGMTSSSCLRHSPRSSFDSHGESDHNLDVPHGSR 2492
                     ||..||      :||.....|.:|       :.:|.:..:......|..: .|..:
Zfish  2164 ---------SPIPSPGADRRGKGSQSATLPTKG-------QETPSAQLEGFLHRKHEWE-GHNKK 2211

  Fly  2493 KRSMSAHGSF------ETGTRPRAQETYQYYPVYDNQ---------------------------T 2524
            ..|.|.|..:      |.|.....:...|..| |.|:                           |
Zfish  2212 ASSRSWHNVYCVINNHEMGFYKDNKNAGQGIP-YHNEIPISLKEAVCEVAVDYKKKKHVFKLRVT 2275

  Fly  2525 CSDHYVAAAPTG-----------RYGGGTSSRSRLSKSLERSTSRDSTTTSS 2565
            ..:.|:..|...           ..|.|:||    |:..|.:.|..||..||
Zfish  2276 DGNEYLFQAKDDEEMNTWIQAIQNAGSGSSS----SEKSETAPSNQSTPASS 2323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 17/145 (12%)
PH 873..974 CDD:278594 12/119 (10%)
TIAM1_RBD 1141..1219 CDD:176413 20/94 (21%)
PDZ_signaling 1221..1308 CDD:238492 14/90 (16%)
RhoGEF 1456..1647 CDD:238091 40/234 (17%)
PH2_Tiam1_2 1650..1823 CDD:269957 38/219 (17%)
PH 1693..1812 CDD:278594 27/154 (18%)
sptbn1XP_009304586.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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