DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and ARHGEF38

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	NP_001229658.1	Gene:	ARHGEF38 / 54848	HGNCID:	25968	Length:	777	Species:	Homo sapiens

Alignment Length:	827	Identity:	171/827 - (20%)
Similarity:	282/827 - (34%)	Gaps:	287/827 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1409 RTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTP------SRQLTDAEKLRKVVMELVDTE 1467
            |:.|...|...|..|    |.:|.|.  .||:.| |||      .|.:.   |..|::.||:.||
Human    52 RSQSDRTEYNQKLQE----KMTPQGE--CSVAET-LTPEEEHHMKRMMA---KREKIIKELIQTE 106

  Fly  1468 RTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEE-SLDLEPDFNKFE 1531
            :.|:..|...:...::|::.:. ....::::||.||..:.....:.|..||| :.|:||
Human   107 KDYLNDLELCVREVVQPLRNKK-TDRLDVDSLFSNIESVHQISAKLLSLLEEATTDVEP------ 164

  Fly  1532 HCGQFRNVLFAIGSAFLYYVNHFK-LYSSFCASHSKAQKVLHPNEGNHALQEFLA--ARNPKQQH 1593
                   .:..||..||......: :|..:|..|.:|..:|...|....|:|.|:  .::.|:.:
Human   165 -------AMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSLKKIY 222

  Fly  1594 SS-------TLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQR 1651
            ..       .:.|.:||||||::||||||.::||.|.....::..|.:|...::.:..:|||::|
Human   223 MQEGKPNLLDMGSLMIKPIQRVMKYPLLLCELRNSTPPSHPDYRALDDAFAAVKDINVNINELKR 287

  Fly  1652 ----------------------------IHEEYGAIFDH---------------------LFRQH 1667
                                        |.::...:.:|                     |||..
Human   288 RKDLVLKYKKNDEDESLKDKLSKLNIHSISKKSKRVTNHLKILTRGESQVKDNTFNREEKLFRAL 352

  Fly  1668 QKS---CKQPIDL--------------SPGDL--LYYGGVEWLNISDFLGKIKKGLELHAMCFVF 1713
            :|:   |.:.|.|              |..||  :.|...:.::.|:.|......      |..|
Human   353 EKTVRLCVKNISLCLQHIQDAMPLALQSVMDLQEISYNKDDEMDYSETLSNALNS------CHDF 411

  Fly  1714 KSAV-------------VFLCKERLRQKK--KLM----------GVSSKNATNEVEIIRYQVLIP 1753
            .|.:             :|....:|.||:  ||:          |..|..|..|.|.:..|:
Human   412 ASHLQRLILTPLSALLSLFPGPHKLIQKRYDKLLDCNSYLQRSTGEESDLAKKEYEALNAQL--- 473

  Fly  1754 VTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVY-------VLSNSTADFRNAFLKTIRQI- 1810
            |.|:|....:|:.:..:.|...|.|...|...:::.|       :|.:|.::.:|..|:.|:.:
Human   474 VEELQAFNQAARKILLNCLCSFITLLRDLMLVAQQAYSTLVPMPLLVSSISEIQNQVLEEIQNLN 538

  Fly  1811 -IRES-----VRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTL-ERPKQQITIVHGSHTL 1868
             ::|:     .|.:|...|.                       ..|.| |.|.|  |.:|.|..|
Human   539 CVKENSATFIERKLSFEKKK-----------------------PVQILPEMPHQ--TDIHRSKLL 578

  Fly  1869 G--------KPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRG 1925
            .        :.|:|..:.:    ..|.:.|.|     ||   |.|:         :|..|.|...
Human   579 STYSAEELYQAKRKCNATQ----EYDINLLEG-----DL---VAVI---------EQKDPLGSTS 622

  Fly  1926 R-SKTVGDVTEITCSS-PEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHH 1988
            | ....|:|.....|| .:|:...:.|:...:.                              ..
Human   623 RWLVDTGNVKGYVYSSFLKPYNPAKMQKVDAEN------------------------------RF 657

  Fly  1989 HSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPA 2053
            ...|.|.|.....|....||..|                   ||..|:|.:.|.
Human   658 CDDDFENISLFVSSRPASDSVTG-------------------TSESSIGDSSSS----------- 692

  Fly  2054 SYQPVLMKDLGKPSPDESELESESE--------VHAAQVAASFNLSL 2092
                 |....||...:.::::|..|        |||.|..:...|||
Human   693 -----LSGTCGKFETNGTDVDSFQEVDEQIFYAVHAFQARSDHELSL 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413
		PDZ_signaling	1221..1308	CDD:238492
		RhoGEF	1456..1647	CDD:238091	51/201 (25%)
		PH2_Tiam1_2	1650..1823	CDD:269957	48/279 (17%)
		PH	1693..1812	CDD:278594	31/152 (20%)
ARHGEF38	NP_001229658.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..72		7/23 (30%)
		RhoGEF	98..284	CDD:279015	51/199 (26%)
		BAR_DNMBP	336..522	CDD:153273	38/194 (20%)
		SH3	586..642	CDD:302595	17/76 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..694		8/55 (15%)
		SH3_DNMBP_C2	717..773	CDD:213017	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3224
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840