DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Kalrn

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:XP_011244253.1 Gene:Kalrn / 545156 MGIID:2685385 Length:2999 Species:Mus musculus


Alignment Length:2005 Identity:369/2005 - (18%)
Similarity:644/2005 - (32%) Gaps:702/2005 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   872 KWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHP 936
            ::|..|:|::||..::..|....||             :.|.::|..|.::              
Mouse   874 EFLHEKQHELELNAEQTHKRLEQCL-------------QLRHLQAEVKQVL-------------- 911

  Fly   937 KRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIFRLEKAI 1001
                                       .|:.:..|...|:.. :.........||.|..:.:.||
Mouse   912 ---------------------------GWIRNGESMLNASLV-NASSLSEAEQLQREHEQFQLAI 948

  Fly  1002 ESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLER-----------------LHCEQF--- 1046
            ||   |.|...||::        ||...|:.|..|.|.:                 ||.:|.   
Mouse   949 ES---LFHATSLQKT--------HQSALQVQQKAEALLQAGHYDADAIRECAEKVALHWQQLMLK 1002

  Fly  1047 ---RLRCYMASL----QSGELPNPKSLLTHVSRPTKNTL---NKLG-------VFTVSSFH---- 1090
               ||:...||:    .|.::.:....|....|..::..   :|||       |..:.|.|    
Mouse  1003 MEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEMDHVIPLLSKHLEQK 1067

  Fly  1091 -AFICARSPSLLNNLLAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTV 1154
             ||:.|.:                    |:|.|:....:.:..|:         |:||..|..| 
Mouse  1068 EAFLKACT--------------------LARRNAEVFLKYIHRNN---------VSMPSVASHT- 1102

  Fly  1155 YLRDAMSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRN-----DLI----ENYLHN 1210
             ......|:..|:....|.  |.:.||..:||||..:...|.|..|:     |.|    |.||..
Mouse  1103 -RGPEQQVKAILSELLQRE--NRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEYYLST 1164

  Fly  1211 H----EFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGI 1271
            |    |..|...::|.:.                .|....|::..|....:.::.|..|  ..|.
Mouse  1165 HTSTGETTEETQELLKEY----------------GEFRVPAKQTKEKVKLLIQLADSFV--EKGH 1211

  Fly  1272 IKGDEIMVINGAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPP 1336
            |...||.    ..|:.:|..|        :..|:.|...|......:|:.  |:|          
Mouse  1212 IHATEIR----KWVTTVDKHY--------RDFSLRMGKYRYSLEKALGVN--TED---------- 1252

  Fly  1337 PTDPPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGL 1401
                                     :|||   |.:..||:                        |
Mouse  1253 -------------------------NKDL---ELDIIPAS------------------------L 1265

  Fly  1402 GVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDT 1466
            ...:...|.::.||       .:|.|||                       |.|...::.||:.|
Mouse  1266 SDREVKLRDANHEI-------NEEKRKS-----------------------ARKKEFIMAELLQT 1300

  Fly  1467 ERTYVKHLNNLLEHYLEPM-----KRETFLSNAEINALFGNIHEIVTFQRQ-FLQNLEESLDLEP 1525
            |:.||:.|:..||.||..|     :....:.|.| :.:||||.||..|... ||:.||:...|..
Mouse  1301 EKAYVRDLHECLETYLWEMTSGVEEIPPGILNKE-HIIFGNIQEIYDFHNNIFLKELEKYEQLPE 1364

  Fly  1526 DFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPK 1590
            |                :|..|:.:.:.|::|.::|.:...:.:::..:.|.. ..|.      :
Mouse  1365 D----------------VGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTF-FDEI------Q 1406

  Fly  1591 QQH--SSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIH 1653
            |:|  ::::.||||||:||:.||.|||:::....:....|   |.:.|:.|..|.:..|:...:.
Mouse  1407 QRHGLANSISSYLIKPVQRVTKYQLLLKELLTCCEEGKGE---LKDGLEVMLSVPKKANDAMHVS 1468

  Fly  1654 EEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVE-WLNISDFLGKIKKGLELHAMCFVFKSAV 1717
            ...|  ||           :.:|:. |:|:.....: |    |....|:||.|.|  .|:|:.::
Mouse  1469 MLEG--FD-----------ENLDVQ-GELILQDAFQVW----DPKSLIRKGRERH--LFLFEISL 1513

  Fly  1718 VFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQL 1782
            ||        .|::     |:::...:.: |:..:..:|:.|......|.....||      |..
Mouse  1514 VF--------SKEI-----KDSSGHTKYV-YKNKLLTSELGVTEHVEGDPCKFALW------SGR 1558

  Fly  1783 QRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNM--------SIP-----MKNFGGSSGSVSG 1834
            ...|:...||..|..:.:..::|.||::|:|.:.::        .:|     ::|.....|...|
Mouse  1559 TPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPIQLPKTPAKLRNNSKRDGVEDG 1623

  Fly  1835 HSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDL 1899
             .|||.||                          .:|...|.:.|.|...::.|.|||..|.   
Mouse  1624 -DSQGDGS--------------------------SQPDTISIASRTSQNTVESDKLSGGCEL--- 1658

  Fly  1900 PPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQ------QQQQQQQQQQLM 1958
              :|.:..:::||:....:|          ||...|:.   ..|.::      :..::...|:.:
Mouse  1659 --TVVLQDFSAGHSSELSIQ----------VGQTVELL---ERPSERPGWCLVRTTERSPPQEGL 1708

  Fly  1959 QQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEG----EEDSQQGTIRPKATL 2019
            ....|....|...........|::..:.|..|.:      |.|||.    :......:|......
Mouse  1709 VPSSALCISHSRSSVEMDCFFPLKDSYSHSSSEN------GGKSESVAHLQSQPSLNSIHSSPGP 1767

  Fly  2020 GRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMKDLGKPSP-DESELESESEVHAAQ 2083
            .|:.|.|....||.:...::|.....|:........:...  |||.|.| ||:..:.:|....::
Mouse  1768 KRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSF--DLGSPKPGDETTPQGDSADEKSK 1830

  Fly  2084 VAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPRQS---PRQSPKQDIEVIEIF 2145
            ..             :..|..|.::.:.....:......|.|....|   .||:| .|:......
Mouse  1831 KG-------------WGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSLLAARQAP-PDVPTAADL 1881

  Fly  2146 ESEAERLAASQQVAVVHQHPSDQARESGHKQRRDRDRNPT----------------ETDATAR-- 2192
            .|..|:|..::...           |.|  ..|...::||                |.:..|:  
Mouse  1882 VSAIEKLVKNKLTL-----------EGG--SYRGSLKDPTGCLNEGMTPPTPPRNLEEEQKAKAL 1933

  Fly  2193 ----FMDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQD-----------------------L 2230
                |:...|...|::.:.|....:..:|:.:.||.. |:|                       |
Mouse  1934 RGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGV-PEDMRGKEKIVFGNIHQIYDWHKDFFL 1997

  Fly  2231 AEDTGDHQQNDSSLSPEPQTIVENTQQTVVVDIESPSRPATESDSTGNTTGPSERSGDETEEEAT 2295
            ||.....|:.|..    .|..:::.::..:......::|.:|     ......:...:|.::|..
Mouse  1998 AELEKCIQEQDRL----AQLFIKHERKLHIYVWYCQNKPRSE-----YIVAEYDAYFEEVKQEIN 2053

  Fly  2296 TSSLASHIVVIDKKVDKIFK--------AKSPERPA--STKVKGGRRQIYISPDRCKSQGSSPVR 2350
            .....|..::  |.:.:|.|        .:..|:..  .:.::.....:.:.|.||...    :.
Mouse  2054 QRLTLSDFLI--KPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDM----MN 2112

  Fly  2351 IIKIKSPRTSLSDQGKRLSVCSSRDNSQD-----RLSAGRRTPSP-----------------RRS 2393
            :.:::....:|:.|||.|        .||     .|.||.::.:.                 |:.
Mouse  2113 LGRLQGFEGTLTAQGKLL--------QQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKG 2169

  Fly  2394 SEGGG------------ILKHTTGPDP-------------------------------------- 2408
            |...|            :|:.....||                                      
Mouse  2170 SLTPGYMFKRSIKMNYLVLEDNVDGDPCKFALMNRETSERVILQAANSDIQQAWVQDINQVLETQ 2234

  Fly  2409 -GILKPPSSPAKSKSPDRS-CLKKGGPSHVCSVETLSPRVSPR----GSMDHLSPDRGMTSSSCL 2467
             ..|....||.:.:..:|| .:.:..|..|       |:.|||    |.:....|.:|.:.:..|
Mouse  2235 RDFLNALQSPIEYQRKERSTAVIRSQPPRV-------PQASPRPYSSGPVGSEKPPKGSSYNPPL 2292

  Fly  2468 ---------------RHSPRSSFDSHGESDHNLDVPHGSRKRSMSAHGSFETGTRPRAQETYQYY 2517
                           .|.|...||:..::|               ..|...|.|....::   ||
Mouse  2293 PPLKISTSNGSPGFDYHQPGDKFDASKQND---------------LGGCNGTSTMTVIKD---YY 2339

  Fly  2518 PVYDNQTC------------------------SDHYVAAAPTGRYGGGTSSRSRLSKSLERSTSR 2558
            .:.:|:.|                        |||..||  .|...|  |..:.|:|:...:.|.
Mouse  2340 ALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAA--EGWVPG--SILAPLAKATAAAESS 2400

  Fly  2559 DSTTTSSSYGH------RAYGVSPDRNYVVFSSGPLRSQ-------SAENTFSSQ 2600
            |.:...|...|      ||...:..:|.   ::||.:.:       |.:.|.||:
Mouse  2401 DGSIKKSCSWHTLRMRKRADVENSGKNE---ATGPRKPKDILGNKVSVKETNSSE 2452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 14/112 (13%)
PH 873..974 CDD:278594 13/100 (13%)
TIAM1_RBD 1141..1219 CDD:176413 26/90 (29%)
PDZ_signaling 1221..1308 CDD:238492 14/86 (16%)
RhoGEF 1456..1647 CDD:238091 54/198 (27%)
PH2_Tiam1_2 1650..1823 CDD:269957 36/186 (19%)
PH 1693..1812 CDD:278594 26/118 (22%)
KalrnXP_011244253.1 SEC14 47..185 CDD:214706
SPEC 198..418 CDD:238103
SPEC 319..544 CDD:238103
SPEC 545..774 CDD:238103
SPEC 899..1137 CDD:238103 61/323 (19%)
SPEC 1143..1243 CDD:197544 25/129 (19%)
RhoGEF 1292..1462 CDD:238091 54/196 (28%)
PH1_Kalirin_Trio_like 1469..1591 CDD:270060 35/161 (22%)
SH3_Kalirin_1 1657..1716 CDD:212786 11/76 (14%)
SH3-RhoG_link 1714..1929 CDD:374666 42/249 (17%)
RhoGEF 1939..2108 CDD:366202 25/180 (14%)
PH2_Kalirin_Trio_p63RhoGEF 2113..2247 CDD:270061 19/141 (13%)
Extensin_2 2259..2311 CDD:252669 11/58 (19%)
SH3_Kalirin_2 2331..2387 CDD:212787 13/62 (21%)
I-set 2478..2572 CDD:369462
FN3 2576..2667 CDD:238020
STKc_Kalirin_C 2697..2944 CDD:271017
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.