| Sequence 1: | NP_001261446.1 | Gene: | sif / 43892 | FlyBaseID: | FBgn0085447 | Length: | 2734 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001104784.1 | Gene: | Ngef / 53972 | MGIID: | 1858414 | Length: | 710 | Species: | Mus musculus |
| Alignment Length: | 525 | Identity: | 104/525 - (19%) |
|---|---|---|---|
| Similarity: | 186/525 - (35%) | Gaps: | 127/525 - (24%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 1333 CPPPPTDPPVMSEEMITGLIVPAPGWNGTSKD---LYSPEAESSPATSFVDPAAMAAQLAVGGVG 1394
Fly 1395 GVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSR-----QLTDAE 1454
Fly 1455 -------------KLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEI 1506
Fly 1507 VTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFA--IGSAFLYYVNHFKLYSSFCASHSKAQK 1569
Fly 1570 VLHPNEGNHALQEFLAAR--------NPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRA 1626
Fly 1627 DEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWL 1691
Fly 1692 NISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVS---------SKNATNEVEIIR 1747
Fly 1748 YQVL------IPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNA--FL 1804
Fly 1805 KTIRQ 1809 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| sif | NP_001261446.1 | WH1 | 35..144 | CDD:214674 | |
| PH1_Tiam1_2 | 860..985 | CDD:269937 | |||
| PH | 873..974 | CDD:278594 | |||
| TIAM1_RBD | 1141..1219 | CDD:176413 | |||
| PDZ_signaling | 1221..1308 | CDD:238492 | |||
| RhoGEF | 1456..1647 | CDD:238091 | 48/200 (24%) | ||
| PH2_Tiam1_2 | 1650..1823 | CDD:269957 | 30/177 (17%) | ||
| PH | 1693..1812 | CDD:278594 | 28/134 (21%) | ||
| Ngef | NP_001104784.1 | Regulatory region, modulates activity toward RHOA, RAC1 and CDC42 | 1..272 | 24/141 (17%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..146 | 2/4 (50%) | |||
| ELH | 3..>156 | CDD:145463 | 4/14 (29%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 192..234 | 11/52 (21%) | |||
| RhoGEF | 277..456 | CDD:279015 | 47/198 (24%) | ||
| PH_ephexin | 477..603 | CDD:269929 | 24/115 (21%) | ||
| PH | 490..596 | CDD:278594 | 22/102 (22%) | ||
| SH3_ephexin1 | 616..670 | CDD:212872 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 688..710 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||