DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and PEX13

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_002609.1 Gene:PEX13 / 5194 HGNCID:8855 Length:403 Species:Homo sapiens


Alignment Length:494 Identity:86/494 - (17%)
Similarity:160/494 - (32%) Gaps:162/494 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1334 PPPPTDPPVMSEEMITGL-IVPAPGWNGTSKDLYSP---EAESSPATSFVDPAAMAAQLAVGGVG 1394
            ||||..|  .....|.|. ..|.||....|.|| .|   .....||.:.|.|..:          
Human     5 PPPPPKP--WETRRIPGAGPGPGPGPTFQSADL-GPTLMTRPGQPALTRVPPPIL---------- 56

  Fly  1395 GVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSS-------------------VS 1440
                     .:|:.:|.|..: |..:.|....  ||..|:..:|                   :.
Human    57 ---------PRPSQQTGSSSV-NTFRPAYSSF--SSGYGAYGNSFYGGYSPYSYGYNGLGYNRLR 109

  Fly  1441 TTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHE 1505
            ...|.|||.:..||:..:...:.:              |..:......:.:.:|..:|::.:...
Human   110 VDDLPPSRFVQQAEESSRGAFQSI--------------ESIVHAFASVSMMMDATFSAVYNSFRA 160

  Fly  1506 IVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCA------SH 1564
            :              ||:...|::.:                   ::..|::|:|..      .:
Human   161 V--------------LDVANHFSRLK-------------------IHFTKVFSAFALVRTIRYLY 192

  Fly  1565 SKAQKVLHPNEG--NHAL----QEFLAARNPKQQHSSTLESYLIKPI----QRILKYPLLLQQMR 1619
            .:.|::|....|  |..|    :..:|....:.:.:::.:|:   ||    ..||..|.|:.:  
Human   193 RRLQRMLGLRRGSENEDLWAESEGTVACLGAEDRAATSAKSW---PIFLFFAVILGGPYLIWK-- 252

  Fly  1620 NLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLY 1684
             |..|.:||   :.:::.......:|:  :.|...::.|:           .::.|....||:|.
Human   253 -LLSTHSDE---VTDSINWASGEDDHV--VARAEYDFAAV-----------SEEEISFRAGDMLN 300

  Fly  1685 YGGVE-------WL--------------NISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQK 1728
            ....|       ||              |....||| :||.:      ..:|:.|...::.....
Human   301 LALKEQQPKVRGWLLASLDGQTTGLIPANYVKILGK-RKGRK------TVESSKVSKQQQSFTNP 358

  Fly  1729 KKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASS-AKD 1766
            ....|.:..::.:|.|.....|.:...:|.|...| .||
Human   359 TLTKGATVADSLDEQEAAFESVFVETNKVPVAPDSIGKD 397

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492
RhoGEF 1456..1647 CDD:238091 27/206 (13%)
PH2_Tiam1_2 1650..1823 CDD:269957 26/139 (19%)
PH 1693..1812 CDD:278594 16/75 (21%)
PEX13NP_002609.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..68 21/84 (25%)
Peroxin-13_N 120..254 CDD:309283 24/186 (13%)
Targeting to peroxisomes 145..233 14/120 (12%)
Interaction with PEX19 175..196 3/20 (15%)
SH3_PEX13_eumet 276..333 CDD:212798 10/67 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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