Protein Alignment sif and arhgef7b

DIOPT Version :9

• Sequence 1: NP_001261446.1
• Gene: sif / 43892
• FlyBaseID: FBgn0085447
• Length: 2734
• Species: Drosophila melanogaster
• Sequence 2: XP_017210203.1
• Gene: arhgef7b / 494081
• ZFINID: ZDB-GENE-041212-49
• Length: 856
• Species: Danio rerio
• Alignment Length: 1144
• Identity: 219/1144 - (19%)
• Similarity: 382/1144 - (33%)
• Gaps: 393/1144 - (34%)

  Fly  1172 RRNLNPMEHFVRVKKR------------RDMEDHN-YFVPHRNDLIENYLHNHEFVEVCMKILYQ 1223
            ::.|:..|.|::...|            |....|. |..|.:::.:.|.   .|||:.|  .||.
Zfish    21 KKTLSDPEGFLQASLRDGVVLCKLLERLRPGSVHTIYQDPRKDECLSNI---REFVKGC--ALYH 80

  Fly  1224 VELQRTTLEQMWGFSVEA-ELIENAERQDELCCYV--SRVEDKSVAMHNGIIKGDEIMVINGAIV 1285
            :|:            .|| :|::.......|.|.|  ::...:|....|.:.
Zfish    81 IEV------------FEANDLLQGQNFSKVLNCLVALNKATSESGGGSNSVC------------- 120

  Fly  1286 SDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPP-------------P 1337
                         ..||.|:.::|                  .|||.|...             .
Zfish   121 -------------SRQSSSLRIKS------------------FDSLNCSSTHRRSSRHKFNQYRS 154

  Fly  1338 TDPPVMSEEMITGLIVPAP-GWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGL 1401
            .|   |||.....::|.|. .:..|::|..|        .|..|...:..|...|...|.:.|
Zfish   155 LD---MSENSAPQVLVKARFNFQQTNEDELS--------FSKGDIIQVTRQEEGGWWEGALNG-- 206

  Fly  1402 GVAKPTSRTSSFEIENLLKTAEQETRKSSP-TGSVTSSVSTTALTPSRQLTDAEKLRK----VVM 1461
                   :|..|. .|.:|..:...:..|| ||::.|        |.:.:..|...:.    ||.
Zfish   207 -------KTGWFP-SNYVKEIKGSDKPVSPKTGTLKS--------PPKAIESANFCKTYYNVVVQ 255

  Fly  1462 ELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPD 1526
            .::.||..|.|.|.|||..||..::....||.::|:.:.||:.||.:||:..:.:|||::.:...
Zfish   256 NILQTETEYCKELQNLLSVYLRALQPTDRLSVSDISHIMGNLEEISSFQQTLVHSLEENVKVSDS 320

  Fly  1527 FNKFEHCGQFRNVLFAIGSAFLYYVNHFK-LYSSFCASHSKAQKVL--HPNEGNHALQEFLAARN 1588
            ..:             ||..||..:...: ||.::|::|..|..||  |..|    |.||:.::.
Zfish   321 QQR-------------IGGFFLSLLTQMRSLYVTYCSNHPSAVNVLTQHSEE----LGEFMESKG 368

  Fly  1589 PKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIH 1653
            .......||.:.|.||..|:.|||.||::|        :.|                   |:.:|
Zfish   369 ANTPGILTLTTGLSKPFLRLEKYPTLLKEM--------ERH-------------------MEPLH 406

  Fly  1654 EEYGAIFDH--LFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFK-- 1714
            .:|..|...  ||:.....|::.                        :.:|.|||..:....:
Zfish   407 PDYPDIQKSMTLFKNLSAQCQEV------------------------RKRKELELQILMESIRGW 447

  Fly  1715 --------SAVVFLCKERLRQKKKLMGVSSKN---------------ATNEVEIIRYQVLIPVTE 1756
                    ..|:|:.:..::..    |...||               |:..:....||..:|:|.
Zfish   448 EGEGIKTLGTVLFMSQVIIQNH----GAEEKNERYLLLFPHILLMLSASPRMSGFIYQGKLPLTG 508

  Fly  1757 VQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFR---NAFLKTIRQIIRESVRNM 1818
            :.|..:...|...| .:|:      .....|::.|:.|:..|.:   :...:..::|...|::..
Zfish   509 MSVSKTEDSDGTKH-AFEI------SGNMIERIQVICNNQQDLQDWVDHLHRQTKRISTSSLKPQ 566

  Fly  1819 SIPMKNF-------------GGSSGSVSGHSSQGMGSMGYPGNSQ---TLERPKQQITIVHGSHT 1867
            |:|....             .|.|||...|:...:.|:|.|.:..   .||.||.|
Zfish   567 SVPCHTLPSHPLTPSRHSESRGVSGSPVYHTLPHLSSLGTPHSGMMWGPLEPPKTQ--------- 622

  Fly  1868 LGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQPAGFRGRSKTVGD 1932
              ||.                :||..:.|..|.||..:.:
Zfish   623 --KPW----------------SLSCLRPAPPLKPSAALCY------------------------- 644

  Fly  1933 VTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPPPPPIRQPHLHHHSSDIERID 1997
             .|....||          :..::|:                 |...|.|:|      ||.|...
Zfish   645 -KEDLSKSP----------KNMKKLL-----------------PKRKPERKP------SDEEFAV 675

  Fly  1998 PGTKSEGEEDSQ-QGTIRPKATLGRTPNHLTLSTTSTLSVGSTGSQARLIQSSHPPASYQPVLMK 2061
            ..:.:..|||:| ...|....|..:|  ..||::|..   |:......::...| .:....|..:
Zfish   676 RKSTAALEEDAQILKVIEAYCTSAKT--RQTLNSTWQ---GTDLMHNHVLADVH-QSCVDAVGCR 734

  Fly  2062 DLGKPSPDESELESESEVHAAQVAASFNLSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQS 2126
            ..|.||.|:||   :|:..:..:..:..:     ||:         ::||.:|..|.|.
Zfish   735 SSGFPSSDQSE---DSDYDSIWITHTNRI-----GSV---------SRSRKESGPHMLF------ 776

  Fly  2127 PRQSPRQSPKQDIEVIEIFESEAERLAASQQVAVVHQHPSDQARESGHKQRRDRDRNPTETDATA 2191
                    |:::..::|..:|..:.:...:.:........|:.:|.  ||...|.:...|.:..|
Zfish   777 --------PEEEKIIVEETKSNGQTVIEERSLVDTVYALRDEVQEL--KQDNKRMKRTLEEEQKA 831

  Fly  2192 RFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDL 2230
            |      .:||:.        :...::|:.:.::|..:|
Zfish   832 R------KELEKV--------VRRVLKSMNDPSWDETNL 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413	13/59 (22%)
		PDZ_signaling	1221..1308	CDD:238492	14/89 (16%)
		RhoGEF	1456..1647	CDD:238091	53/197 (27%)
		PH2_Tiam1_2	1650..1823	CDD:269957	32/202 (16%)
		PH	1693..1812	CDD:278594	23/146 (16%)
arhgef7b	XP_017210203.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910