DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sif and Y37A1B.17

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_001076722.2 Gene:Y37A1B.17 / 4926960 WormBaseID:WBGene00044989 Length:1523 Species:Caenorhabditis elegans


Alignment Length:1791 Identity:339/1791 - (18%)
Similarity:599/1791 - (33%) Gaps:543/1791 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1132 MNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEF--LASACARRNLNPMEHFVRVKKRRDMEDHN 1194
            ::.:.:|::  :|.....||::: ..|.:|..||  ..:..:|.|...::.|:       :.|:.
 Worm    59 VDPKRQPDE--QVYCSIEAYTSI-RSDDLSFAEFSIFVAKPSRSNPGYLDGFL-------VNDNA 113

  Fly  1195 YFVPHRNDLIENYLHN-HEFVEVCMKILYQVELQRTTLEQMWGFSVEAELIENAERQDELCCYVS 1258
            ..:..|..|.|.:|.| |...|..||..:..:.....:.    |...|...:.|.....:..|..
 Worm   114 VQIGRRGLLPEAHLVNLHVSAESPMKPSFTTDFSEADVR----FRTPATAPKAATSNYAVSPYAR 174

  Fly  1259 RVEDKSVAMHNGI-IKGDEIMVINGAIVSDLDMMYLESVL---------------------QEEQ 1301
            .|.|......|.: ...|||:.:...|    |..:||..:                     .:..
 Worm   175 AVYDFQGEFENELSFSADEIISLRRRI----DAEWLEGSIGSARVGIFPTSFVQIIVDLPDDDTT 235

  Fly  1302 SLSMMMRSSRTE------------------------PPDLVGIMRVTDDMIDSLVCPPPPTDPPV 1342
            ||....||:.||                        ..|.|.::|:.:|  :.::|..|.|:.  
 Worm   236 SLQNNRRSTTTENDGIGFANVRHAFSGRQGDELTVNAGDTVRVLRMVND--EWVMCKDPDTEK-- 296

  Fly  1343 MSEEMITGLIVPA---------------------PGWNGTS---------KDLYSPEAESS---- 1373
                  || |||.                     .|..|||         :..:...||||    
 Worm   297 ------TG-IVPVGFLEVYLDEEDDDNQSSNAMRRGTGGTSDFTFGSSNNRSSFISNAESSSDWR 354

  Fly  1374 -PA-------TSF--VDPAAMAAQLAVGGV--GGVVVGGLGVAK-------PTSRTSSFE--IEN 1417
             ||       .:|  |.|||.|::.|....  |...:..:.:||       |..:.||.:  |.:
 Worm   355 PPAGRTNTDWATFEAVPPAAPASKPAQNWATFGEEWIAPVQLAKTSAPARPPPPKQSSIQSPIND 419

  Fly  1418 LLKTAEQ----ETRK-SSPTGSVTSSVSTTALTPSRQ--LTDAEKLRKVVMELVDTERTYVKHLN 1475
            :...|:.    :|.| |:|......|.....|..:.:  ..|.:|..:::.||:.:|..::..:|
 Worm   420 IGNVADMFGMTDTPKPSNPAIQSAGSDFEIGLISATEGASNDEDKRCRIIEELISSELQFISDIN 484

  Fly  1476 NLLEHY----LEPMKRETFLSN--AEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCG 1534
            :..|..    |...|::..|.|  |:|..|..|:.:::|.::...|:.:                
 Worm   485 SYTEAVDGTPLLNQKQKVILKNGCAQIVQLSANLVQLLTNEQIKPQDAQ---------------- 533

  Fly  1535 QFRNVLFAIGSAFL------------YY--VNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLA 1585
                   .||:.||            |:  :.|....:: .|.|.|..:        .|||:.: 
 Worm   534 -------LIGACFLQLRKPFAQTYGFYFRNIEHINALTN-SAKHEKTME--------SALQDIV- 581

  Fly  1586 ARNPKQQHSSTLE--SYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINE 1648
             :..::..|..::  :.:.:||||..||||.|.::..||.....:|..|.||:|.|..:.:.:||
 Worm   582 -KRMRESGSVVIDGPTAVSRPIQRATKYPLFLNEIVKLTPLVHTDHPKLTEAIKQMSNLGQKMNE 645

  Fly  1649 MQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLN-----ISDFLGKIK--KGLEL 1706
            .:|..|        |.:::....||........:.::...:..|     :...||.:|  :..:.
 Worm   646 SKRRKE--------LTQKYMSDDKQTFGEMLSKMTFHSLKKKSNRFTYRMGSSLGVVKLLRDTDF 702

  Fly  1707 HAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHF 1771
            ..:.....||     :.||.:...:|.:..|...:|..::.::   .|.|.:.:..|:.::|   
 Worm   703 DRLVCELDSA-----ERRLVRFNYMMVIYRKKMFHETRVLMHK---KVVEPRKKHLSSSEID--- 756

  Fly  1772 LWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHS 1836
                  |:.|....:.|.:. |.:....|:..:|.:|.|.:..::..:..:.::     ..|...
 Worm   757 ------LQLQPFNHAIKTWA-SEANVRIRDEIVKALRSIPKRLIKKRNDKLMDY-----EASRTK 809

  Fly  1837 SQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPP 1901
            .:|:|...:      .|..|                             ||:.|: :|....||.
 Worm   810 EKGLGKRDF------AEIQK-----------------------------DYEALN-TQVKQQLPK 838

  Fly  1902 SVGVVHYASGHTHGQQMQPAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAH 1966
               |..|.:                       |.:..|.....:|.:...:..::|.....:.|.
 Worm   839 ---VTEYLT-----------------------TVLATSMRTVSEQDKALMETLRKLFNDAKSKAA 877

  Fly  1967 PHPHPHPRE-PPPPPIRQPHLHHHSSDIERIDP----GTKSEGEEDSQQGTIRPKATLGRTPNHL 2026
            .......|. ..|..|.....:    |.:|:.|    ..|:......:..::.||   |..|...
 Worm   878 EDQSKAARSLIIPTTICFVDYY----DQDRMKPLQKIANKAIQNMKQRARSVSPK---GSKPGTS 935

  Fly  2027 TLSTTSTLSVGSTGSQARLIQSSHPPASYQ--PVLMKDLGKPSPDESELESESEVHAAQVAASFN 2089
            :.|||.|.|..:|.      .:..|||:.:  |.:.:  |..|..:...::.:|.:.....|:  
 Worm   936 SSSTTVTESPWATA------PTFIPPAATEILPTITE--GSTSTHKFRNQNATERNTILEKAT-- 990

  Fly  2090 LSLGSSGSLFASDARDNQTQSRTQSQIHSLHPSPRQSPRQSPRQSPKQDIEVIEIFESEAERLAA 2154
             :.|..|.:|.:.               |.:|               ||..:::|..:|.:.|..
 Worm   991 -AKGRLGDIFVAT---------------SHYP---------------QDSGMLKIALAEGKLLIV 1024

  Fly  2155 SQQ---VAVVHQHPSDQARESGHKQRRDRDRNPTETDATARFMDKHLSDLEQENLTDGTCDIVAY 2216
            .|.   :||..:.||.....:|:...    ..|:........::|.:...:....|..|..:|| 
 Worm  1025 KQNDLVLAVNREVPSMWLCYNGYYNA----MLPSSILKPYTSIEKGVDVAKSAQFTGQTAQVVA- 1084

  Fly  2217 MESLREKAFDPQDLAEDTGDHQQNDSSLSPEPQTIVENTQQTVVVDIE----SPSRPATESDSTG 2277
                      ||...::     ||    :|:.|.:         :|:|    .|.:||..:..|.
 Worm  1085 ----------PQAPVQN-----QN----APKSQNL---------IDLEDLFGGPPQPAAAAHPTS 1121

  Fly  2278 NTTGPSERSGDETEEEATTSSLASHIVVIDKKVDKIFKAKSPERPASTKVKGGRRQIYISPDRCK 2342
            ....|:::..:....:.|:|.|....:|          .::|.:.|........:.:.::|    
 Worm  1122 LAFAPAQQQQNFATFDFTSSPLQPTSLV----------PQAPAQNAQFDWNMAAKTLPLAP---- 1172

  Fly  2343 SQGSSPVRIIKIKSPRTSLSDQ----GKRLSVCSSRDNSQDRLSA---GRRT---PSPRRSSEGG 2397
                :|...:..::|:.....|    |...::  ..||....||.   |.:|   |.|..|:.. 
 Worm  1173 ----APPMQVSQQAPQQQQQVQEGAGGANYNL--DLDNLFSGLSTIDWGAKTSTAPPPLYSNTP- 1230

  Fly  2398 GILKHTTGP----------DPGILKPPSSPAKSKSPDRSCLK--KGGP---SHVCSVETLSPRVS 2447
              |...|.|          ..|:..|.|.|.::..|....:.  :..|   :.|.:....:|..|
 Worm  1231 --LDTATSPPVSAFRGVDFQTGVFNPNSLPDEAPPPLPVIVNPTRDDPFSTNFVPNFAAAAPATS 1293

  Fly  2448 PRGSMDHLSPDRGMTSSSCLRHSPRSSFDSHGESDHNLDVPHGS--RKRSMSAHGSFETGTRPRA 2510
            |.|           |:|:.....| .|||....|..:|.:|.||  :|||.||            
 Worm  1294 PFG-----------TASNSSVQFP-VSFDEAPSSMGSLGLPTGSMNQKRSASA------------ 1334

  Fly  2511 QETYQYYPVYDNQTCSDHYVAAAPTGRYGGGTSSRSRLSKSLERSTSRDSTTTSSSYGHRAYGVS 2575
                                ||.||..: ..||..||.........||......:.|        
 Worm  1335 --------------------AAQPTNVW-PTTSMMSRSDSPQPLIPSRPEPAVKNVY-------- 1370

  Fly  2576 PDRNYVVFSSGPLRSQSAENTFSSQ-----PIYDPLPRHPPQPLH-QPPMHHQQQQ----QQQQQ 2630
            |..|     .|..|:.:...||.||     |:|..:|.......: .|||:....|    |.|||
 Worm  1371 PSLN-----DGSARAPTFATTFPSQANQSLPMYSAVPNDTMSMNYAMPPMYDTTPQSPRVQLQQQ 1430

  Fly  2631 QQYMSY------APEMGGYTGCQHDPQGGYQLSSSAPEYTTCIDCLYQKRPSXHKSRVRQSRTRK 2689
            .|..:|      ||        .:|     ||.:.:|..|.....|.|.:...  ..:.|...:.
 Worm  1431 HQPAAYDTPPTIAP--------IYD-----QLPNESPASTAIRPVLCQVKVDY--DFLPQGSNQV 1480

  Fly  2690 KTPRGMVVVSAQPT-------------ATGGIGFVP 2712
            :...|.|:...|.|             .:|.:|:||
 Worm  1481 EVKEGEVIGVLQRTDDDGNPEWLLIKRDSGKVGYVP 1516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413 18/80 (23%)
PDZ_signaling 1221..1308 CDD:238492 16/108 (15%)
RhoGEF 1456..1647 CDD:238091 45/212 (21%)
PH2_Tiam1_2 1650..1823 CDD:269957 28/179 (16%)
PH 1693..1812 CDD:278594 22/120 (18%)
Y37A1B.17NP_001076722.2 SH3 169..224 CDD:214620 11/58 (19%)
SH3 250..306 CDD:214620 12/66 (18%)
RhoGEF 468..645 CDD:295373 45/210 (21%)
BAR 643..870 CDD:299863 47/319 (15%)
WWbp <1387..1444 CDD:304964 16/56 (29%)
SH3 1470..1522 CDD:302595 9/49 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

Return to query results.
Submit another query.