DRSC/TRiP Functional Genomics Resources

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Protein Alignment sif and trio

DIOPT Version :9

Sequence 1:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster
Sequence 2:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster


Alignment Length:2438 Identity:449/2438 - (18%)
Similarity:764/2438 - (31%) Gaps:818/2438 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   173 LSTPASPSRVRQEPQCTCMSAEQYARLRTDPRVRGSSTLPRNVGSHRITDVDGQQQVGSG----- 232
            |..||:|.|.|.:|       |...|| ....:...|...:|:|...|.|:.|.....:.     
  Fly    32 LCFPATPRRDRLKP-------EDLRRL-LSYLISIPSDAAKNLGFTVIIDMRGNGNCSTNVKTIL 88

  Fly   233 KVVSAVSSTSLYDNVASGGPGTNQGADTLPRQMKGGQQDRQDVANSGVNTNTPGVIVTGVGNV-- 295
            ||:....|.::::.|             :.:.....|:.|..:::......|..|.:..:..:  
  Fly    89 KVLQEHFSANIHNVV-------------IIKPDNFWQKQRASISSHKYKFETTTVSIESLNKIVE 140

  Fly   296 ----GSDMCGQNHVGSQVGNDDPAACQMDMDLSKSEGTQAG--GGLHQSVGTCTSSSKGTGTRNK 354
                ..|..||.....|...|...|.:   |.....|..|.  ..|.:.:           .|| 
  Fly   141 SHQLTGDFEGQQLYDHQQWTDARLAIE---DFFWQAGDMADRIDDLQEDL-----------NRN- 190

  Fly   355 DFGDDMTRDAHSHDMHQHNVINNNTRRK-TK-STEDMNVDTSTLKRMLKPM--PSTESPVTS--P 413
            ||.:|:....|:.|.|      |..|:| || ..||:::....|...:..|  |..::|..|  |
  Fly   191 DFAEDVPLARHAIDHH------NEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGGQAPTNSGGP 249

  Fly   414 EMGRRRYNYYNANAAQTLGHPPHMHQHGMAMGMGGGGGGGHHIMNNNTMGRASSQSSR-----FS 473
            :|.         :...:.|......|...::|            .|..|..|.:::.|     .:
  Fly   250 DMD---------SGPSSAGQQSQPSQQSRSVG------------GNPDMSAAVNKALRQIELIHT 293

  Fly   474 GSRS-----SH---EIGRGYPPRNLYLELER------------ERSCIE---GSPPSDNVMFDNQ 515
            |...     .|   ::.:.:..|....:.|:            :.|.:|   ....:.::..::|
  Fly   294 GQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQ 358

  Fly   516 CYATTPSSSNGNSDQDQSYGQQQSSGQHPQQQQ-----------------GPPQRSSRHQ----- 558
            .:|....:.:.|.|:..:...:....||...|.                 |..:|::..|     
  Fly   359 KFAVASMNVSVNIDRILAVAARLIESQHYAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLF 423

  Fly   559 HH--HQQAPNVT----------PTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQS 611
            ||  .|...:|.          |.|....|   ||..:....:|.:.|......:|:....|...
  Fly   424 HHKAEQYCNSVASWAAACQASQPLPSDIQS---LETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQ 485

  Fly   612 MENLEFAESLPGSNQRSP--YPLRRPNAKSSTLP-------------------------LPPHRP 649
            :::|     :...||..|  .|..|.|:.:.:..                         |..||.
  Fly   486 LDHL-----VQVCNQPPPPGVPDHRKNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRT 545

  Fly   650 LSTIRDKERDRDRDGYYSDRNELIRERERERD----RGYLSDHNSSFSNSRCASCIGES---ARA 707
            |.....:||.|        .::.:..|..:.|    ..:|.:|...|......  ||.:   ||.
  Fly   546 LEAKWHQERLR--------LHQTLALRLFQEDVKQVLDWLKNHGEVFLRKNTG--IGRNFHKARV 600

  Fly   708 QWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLNDSGYKSARADSLE 772
            ....|.:......:|..:.........::..|| :..| :.:.|:.::..|....:    |:.:|
  Fly   601 YQTSHDNFENVAQNTYSNAQKLLAAADELARSG-EADP-NEIYSVARELELQVGSF----AERVE 659

  Fly   773 QRAEFIRQ---------------DSLRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSEISDDD 822
            ||...:..               |.||::..:| |:|   :.|.::|..:.    :......|..
  Fly   660 QRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTD-ETR---LSQENLEGIER----ILQQYQRDQQ 716

  Fly   823 RMSLTTAVSDEDDGESV---MASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLLRKKHQIELA 884
            ..|:...::....||::   |.|...|..||:.|:.......:.|......:.|..||.....:.
  Fly   717 ESSVNVCLTTISQGEALLQEMRSLEYADNTGSIAALEATLEKLNKQKVELEELWSARKFRADLIL 781

  Fly   885 RKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHP--KRDYIFCLSTA 947
            |.|               ::..|:|           |:.|...:.....:|.  .|||       
  Fly   782 RLR---------------YFERDAR-----------LLSVQMEMWSEELQHADLSRDY------- 813

  Fly   948 FGDAYLFQAPCQVELEN-WVNSIHSA--------------------CAAAFARHRGKTGTLHLLQ 991
                  .:|...:.:.| .|..|.:|                    .:.|.|.|..:....:||.
  Fly   814 ------QKAEQLIRMHNESVTEIQNATYEVVQQGQDLLQLFENAGFISMADATHTAQARIEYLLD 872

  Fly   992 EEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQ---TQILQWEENLERLHCEQFRLRCYMA 1053
               |..|:.|:    |:.|:|.:::.:.......|.|   .|::.|                   
  Fly   873 ---FLREREID----LEEMSEAKRAKLEQAVQLCQFQNDANQVISW------------------- 911

  Fly  1054 SLQSGELPNPKSLLTHVSRPTKNTLNK------LGVFTVSSFHAFICARSPSLLNNLLAGRGATK 1112
             :::||.....|.:|..|......|.|      :.:....:....:..|:.:|:|       |..
  Fly   912 -IRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKYRADALIN-------ANH 968

  Fly  1113 RRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASACARRNLNP 1177
            ..|..:...:...:::..|:.:..| |:...|....|.|.|                 |.:..:.
  Fly   969 YDPLSIDEISDDVTKKWQQLVTYAE-ERHKLVTASINFYKT-----------------AEQVCSV 1015

  Fly  1178 MEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHE-----FVEVCMKILYQVELQRTTLEQMWGF 1237
            ::...|..||.|..........:...|...:..|:     |::.|       .|.|.|.|     
  Fly  1016 LDSLEREYKREDDWCDGGGGSDKAQAIVQLISKHQEQKEAFLKAC-------TLARRTAE----- 1068

  Fly  1238 SVEAELIENAERQDELCCYVSRVE-------DKSVAMHNGIIKGDEIMVINGAIVSDLDMMYL-E 1294
                ..::.|.|..:...|....|       ||.:...|.:                ||...| :
  Fly  1069 ----TFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQENQV----------------LDYWTLRK 1113

  Fly  1295 SVLQEEQSLSMMMRSSR--------------TEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSE 1345
            ..|.:.|...:..||::              :...:||||                       |:
  Fly  1114 KSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGI-----------------------SK 1155

  Fly  1346 EMITGLIVPAPGWNGTSK---------------------------------------------DL 1365
            |...||:.....:..|:|                                             |.
  Fly  1156 EETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDS 1220

  Fly  1366 YSPEAESSPATSFVDPAAMAAQLAVGGVGGVVV---GGLGVAKPT--SRTSSFEIENLLKTAEQE 1425
            |..:.|.|...|       ..||.:|..|...:   .|...:.||  ::.:|...||  |...:|
  Fly  1221 YCEQLEKSLGMS-------QQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNKEN--KEINEE 1276

  Fly  1426 TRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETF 1490
            .|||                       |.:...::.||:.|||.||..|...::.:||..:....
  Fly  1277 KRKS-----------------------ARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKS 1318

  Fly  1491 LSNAEI---NALFGNIHEIVTF-QRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYV 1551
            :.:|.|   :.:||||.||..| |:.||:.||:...:..|                :|..|:.:.
  Fly  1319 VPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPED----------------VGHCFVTWA 1367

  Fly  1552 NHFKLYSSFCASHSKAQKVLHPNEGN--HALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLL 1614
            :.|.:|..:|.:...:..:|..:.|:  ..||..|...:|       |.:|||||:|||.||.||
  Fly  1368 SKFDMYVHYCKNKPTSNNLLVQHGGSFFEELQRRLEVDHP-------LPAYLIKPVQRITKYQLL 1425

  Fly  1615 LQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSP 1679
            |:.:.:..:   :.|..:.|.|:.|..|.:..|:..           ||  ...::|...:| ..
  Fly  1426 LKDLLSCCE---ESHGEIKEGLEVMLNVPKKANDAM-----------HL--SLLENCDVSVD-KL 1473

  Fly  1680 GDLLYYGGVE-WLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEV 1743
            |:::.....: |    |....|:||.|...  |:|:..::| .||                ..|.
  Fly  1474 GEVVLQDAFQAW----DTKQIIRKGRERRV--FLFELYLLF-AKE----------------VKES 1515

  Fly  1744 EIIRYQV--LIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKT 1806
            .:::||.  .:..|::.:......|.....:|     ..:....|:...||..::.:.:..::|.
  Fly  1516 NVVKYQFKSKLMTTDMGITEHIEGDETKFAVW-----TGRSPMLSDCRIVLKATSLETKQIWVKK 1575

  Fly  1807 IRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITIVHGSHTLGKP 1871
            :|::::|:.                             :.|.|.||  ||             .|
  Fly  1576 LREVMQETC-----------------------------FSGTSLTL--PK-------------SP 1596

  Fly  1872 KKKSGSQRHS----------------------AGN-IDYDNLSGSQEADDLPPSVGVVHYASGHT 1913
            .|.|||.:.|                      :|| .|.||..|:|||..:     |..|     
  Fly  1597 AKHSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWV-----VADY----- 1651

  Fly  1914 HGQQMQPAGFRGRSKTVGDVTEI----TCSSPE-------PHQQQQQQQQQQQQLMQQGHAHAHP 1967
                :..:|....|.:.|...||    |...|:       |        |.....:|:|..    
  Fly  1652 ----IATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNP--------QHDDAAVQEGLV---- 1700

  Fly  1968 HPHPHPREPPPPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTS 2032
                 |.....||   |..|.|.|........:....:.|.|..:.|.||.        .|| :|
  Fly  1701 -----PVSVLKPP---PGSHKHGSGTAANAASSAGSQKSDMQDQSNRSKAD--------ALS-SS 1748

  Fly  2033 TLSVGSTGSQARLIQ----SSHPPASYQPVLMKDLGKPSPDESELESESEVHAAQVAASFNLSLG 2093
            |...|.:|.....:.    :..||:| :|::.|      |.|..|.:..: ||.::|...|...|
  Fly  1749 TKRRGFSGRNWLPLMNRKGTDKPPSS-KPLVKK------PSEKNLRTPQK-HAEELAEQQNQQPG 1805

  Fly  2094 SSGSLFASDARDNQTQSRTQSQIHSLHPS------------------PRQSPRQSPR-------- 2132
            :|.   |:....:|..|.||      ||.                  |...|.|.|.        
  Fly  1806 ASP---ATVLPSSQFPSSTQ------HPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPA 1861

  Fly  2133 ------------QSP-KQD----IEVIEIFESEAERLAASQQVAVVHQHPS----------DQAR 2170
                        .|| |.|    .|:.||.::..|            ||.|          :.|.
  Fly  1862 FAKDAKESSGNMASPGKMDGNPLSEIEEIVKTTTE------------QHESNSRVDGGGGVENAS 1914

  Fly  2171 ESGHKQRRD-RDRNPTETDATARFMDKHLSDLEQENLTDGTCDIVAYMESLREKAFDPQDLAEDT 2234
            .:||.:..| .|.:.|.....|..:.|.            .|.....|.:  |:|: .|||.|..
  Fly  1915 TNGHGRSHDNNDESHTAVSDKAAALKKR------------QCVFAELMST--EEAY-VQDLHEIV 1964

  Fly  2235 GDHQ---QNDSSLSPEPQTIVENTQQTVVVDIE 2264
            ..:.   .|.:|..|.|:.:.....:.|..:|:
  Fly  1965 NGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIK 1997

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937 22/147 (15%)
PH 873..974 CDD:278594 18/123 (15%)
TIAM1_RBD 1141..1219 CDD:176413 13/82 (16%)
PDZ_signaling 1221..1308 CDD:238492 16/94 (17%)
RhoGEF 1456..1647 CDD:238091 55/196 (28%)
PH2_Tiam1_2 1650..1823 CDD:269957 28/175 (16%)
PH 1693..1812 CDD:278594 21/120 (18%)
trioNP_651960.2 SEC14 13..152 CDD:214706 26/140 (19%)
SPEC 314..>468 CDD:238103 24/156 (15%)
SPEC 563..778 CDD:238103 42/230 (18%)
SPEC 782..997 CDD:238103 45/288 (16%)
SPEC 897..1119 CDD:238103 47/298 (16%)
SPEC 1125..1226 CDD:197544 14/123 (11%)
RhoGEF 1287..1456 CDD:279015 55/194 (28%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 26/150 (17%)
PH 1495..1580 CDD:278594 17/108 (16%)
SH3_Kalirin_1 1643..1707 CDD:212786 16/94 (17%)
RhoGEF 1945..2122 CDD:279015 13/56 (23%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45462263
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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