DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sif and MCF2

DIOPT Version :9

Sequence 1:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster
Sequence 2:	XP_005262470.1	Gene:	MCF2 / 4168	HGNCID:	6940	Length:	1044	Species:	Homo sapiens

Alignment Length:	971	Identity:	191/971 - (19%)
Similarity:	341/971 - (35%)	Gaps:	294/971 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   985 GTLHLLQEEIFRLEKAIES-DHKLKHMAELQQSVVTD-QETRHQIQTQILQWEENLERLHCEQFR 1047
            |||.....|......|||: ...:|.||::.||..|: .||  ::...|...||.| .:..|::.
Human   185 GTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAET--ELPDDIPSIEEIL-AIRAERYH 246

  Fly  1048 LRCYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGV----FTVSSFHAFICARSPS----LLNNL 1104
            |.              |:.:|.|::..|..|..|.|    ..|||  ...|.|..|    .:|.|
Human   247 LL--------------KNDITAVTKEGKILLTNLEVPDTEGAVSS--RLECHRQISGDWQTINKL 295

  Fly  1105 LAGRGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEFLASA 1169
            |.                                    :|...:.|:...:.:..:.:|::|...
Human   296 LT------------------------------------QVHDMETAFDGFWEKHQLKMEQYLQLW 324

  Fly  1170 CARRN-----------LNPMEHFV-----------RVKKRRDMEDHN--------YFVPHRNDLI 1204
            ...::           ||......           ::||..::::::        :.:.|.:.|.
Human   325 KFEQDFQQLVTEVEFLLNQQAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLA 389

  Fly  1205 ENYLHNHEFV-EVCMKILY------------QVELQRT-----TLEQMWGFSVEAELI------- 1244
            .|:.:..:.: :.|.::.|            :::|.||     .|:|......|.|.:
Human   390 ANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEID 454

  Fly  1245 -----ENAER--QD-----ELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLDMMYLESVL 1297
                 |:|::  ||     |:.......|.:::.....:|...|:.|....|  .|.:..:.|:.
Human   455 KFQSKEDAQKALQDIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTI--QLKLENIRSIF 517

  Fly  1298 QEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSL--VCPPPPTDPPVMSEEMITGLIVPAPGWNG 1360
            :.:|:                |...:.|..:..:  |.|.|        |.::|         :|
Human   518 ENQQA----------------GFRNLADKHVRPIQFVVPTP--------ENLVT---------SG 549

  Fly  1361 TSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQE 1425
            |                   |...:.|:.||.............|.|.|.:...::..:....||
Human   550 T-------------------PFFSSKQVGVGYSFFQACKLFSKGKKTWRQNQSNLKIEVVPDCQE 595

  Fly  1426 TRKSSPTGSVTSSVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKR-ET 1489
            .|.|.|:.|:.:..|...|.           ..|:.||:.|||.||:.|..:|..|...|.. |.
Human   596 KRSSGPSSSLDNGNSLDVLK-----------NHVLNELIQTERVYVRELYTVLLGYRAEMDNPEM 649

  Fly  1490 F------LSNAEINALFGNIHEIVTFQRQ-FLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAF 1547
            |      |.|.: :.||||:.||..|... ||.:|             |:|.....   .:|..|
Human   650 FDLMPPLLRNKK-DILFGNMAEIYEFHNDIFLSSL-------------ENCAHAPE---RVGPCF 697

  Fly  1548 LYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYP 1612
            |...:.|::|:.:|.:..:::.:..    .::...|......|.:|...|:|||:||:|||.||.
Human   698 LERKDDFQMYAKYCQNKPRSETIWR----KYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQ 758

  Fly  1613 LLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINE-MQRIHEEYGAIFDHLFRQHQKSCKQPID 1676
            |||:::...:.. .:....|.:||..|..:.:.:|: |.:|     ||..::...::.
Human   759 LLLKELLKYSKD-CEGSALLKKALDAMLDLLKSVNDSMHQI-----AINGYIGNLNEL------- 810

  Fly  1677 LSPGDLLYYGGVE-WLNISDFLGKIK-----KGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVS 1735
               |.::..||.. |:.......|:|     |.::.|  .|:::.|:|| ||.|         |.
Human   811 ---GKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRH--LFLYEKAIVF-CKRR---------VE 860

  Fly  1736 SKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFR 1800
            |...::......::....:.||.:......|.....:|         ....|:||::..|..|.:
Human   861 SGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIW---------YGEKEEVYIVQASNVDVK 916

  Fly  1801 NAFLKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITI 1861
            ..:||.||.|:.:....:::..:.                      ...|..||.|.||::
Human   917 MTWLKEIRNILLKQQELLTVKKRK----------------------QQDQLTERDKFQISL 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937	191/971 (20%)
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413	12/108 (11%)
		PDZ_signaling	1221..1308	CDD:238492	21/122 (17%)
		RhoGEF	1456..1647	CDD:238091	55/198 (28%)
		PH2_Tiam1_2	1650..1823	CDD:269957	34/178 (19%)
		PH	1693..1812	CDD:278594	27/123 (22%)
MCF2	XP_005262470.1	SEC14	48..188	CDD:214706	2/2 (100%)
		SPEC	328..519	CDD:238103	28/192 (15%)
		RhoGEF	615..792	CDD:238091	55/209 (26%)
		PH-like	799..930	CDD:302622	33/161 (20%)
		PH	842..927	CDD:278594	23/105 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910